Authors: A. Žourková 1; E. Hadašová 2; L. Pulkrábková 1; M. Robeš 1; B. Ravčuková 3 Authors‘ workplace: Psychiatrická klinika LF MU a FN, Brno ; přednostka prof. MUDr. E. Češková, CSc. Farmakologický ústav LF MU, Brno 1; přednostka prof. MUDr. A. Šulcová, CSc. Oddělení lékařské genetiky FN, Brno 2; přednostka prim. MUDr. R. Gaillyová 3 Published in: Čes. a slov. Psychiat., 102, 2006, No. 4, pp. 183-188. Category: Original Article
The choice of a suitable antidepressant for maintenance therapy depends not only on the efficacy of the drug to be administered, but on its metabolization and the gender of the patient, his/her age and/or other medication, too. The goal of the study was to compare the therapeutic effect and incidence of sexual dysfunction in patients in paroxetine maintenance therapy treating a depressive and/or anxiety disorder with respect to gender and CYP2D6 activity. The findings support equal CYP2D6 activity in both genders and equal antidepressant effect disregarding the gender and CYP2D6 activity. A unique finding of the study is varying incidence of sexual dysfunction depending on CYP2D6 activity within the group of female patients.
Key words: antidepressants, CYP2D6, gender, efficacy, sexual dysfunction.
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