Authors: E. Češková; T. Kašpárek Authors‘ workplace: Psychiatrická klinika LF MU a FN, Brno, přednosta prof. MUDr. E. Češková, CSc. Published in: Čes. a slov. Psychiat., , 2003, No. 4, pp. 189-193. Category:
Polypharmacotherapy is very frequently used in the bipolar and psychotic depression and in thepharmacoresistant schizophrenia. For all these indications only a few controlled double-blindstudies are available. Emergence of atypical antipsychotics represents another aspect of theproblem. In the bipolar depression, mood stabilizers or their combinations are adequate for milddepression only. In more severe depression the transitory use of combinations with antidepressantsis recommended; in resistant and psychotic depression combinations with atypical antipsychoticscan be temporally used. In pharmacoresistant schizophrenia the augmentation strategies(lithium, anticonvulsants) are not applied very often, the combinations of several antipsychoticswith different and mutually complementary pharmacological profile have been employed morefrequently. Such combinations should be used after a trial of monotherapy with clozapine.
Key words: polypharmacotherapy, bipolar depression, psychotic depression, pharmacoresistantschizophrenia, combination, augmentation.
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