Substitution Treatment of Dependence on Heroin with Buprenorphine

Czech version

Authors: K. Hampl
Authors‘ workplace: Ordinace AT pro prevenci a léčbu závislostí NsP, Mělník, vedoucí lékař MUDr. K. Hampl, CSc.
Published in: Čes. a slov. Psychiat., , 2003, No. 3, pp. 163-167.
Category:

Overview

Buprenorphine originally used for detoxification of patients addicted to heroin started to be usedalso for short-term substitution treatment. Practice showed that it is suitable also for long-termsubstitution. It is particularly interesting because of its agonistic and antagonistic action onopioid receptors.Experience with buprenorphine in a total of 32 out-patients – mean age 22–23 years – with a reporteddaily dose of heroin of 0.4 to 2.5 g is described. Does of 2–8 mg buprenorphine per day provedsufficient for long-term treatment of patients addicted to heroin.Termination of treatment is sometimes associated with the phenomenon of the last drug dose. Theauthor describes undesirable complications among which the most serious one is abuse of buprenorphinefor administration by injection.

Key words:
heroin addiction, buprenorphine substitution, last drug dose phenomenon.

Full text is not available online.

If interested in a scan of this journal, contact NTO ČLS JEP.

Labels

Addictology Paediatric psychiatry Psychiatry

Ethical Problems of Child and Adolescent Psychiatry

Polypharmacotherapy – when is it Treatment of the First orSecond Choice? Part I.

Possible Pharmacological Effect on AggressiveBehaviour of Patients with Dementia

Contemporary Trends in Psychotherapeutic Research: I. Research of thePsychotherapeutic Effect

Treatment of SSRI in the Practice of Psychiatric Ambulances in the CzechRepublic – Open, Non-intervention Six-month Study with Sertraline Hydrochloride (Zoloft®)

Article was published in

Czech and Slovak Psychiatry

2003 Issue 3