Authors: L. Vavrušová Authors‘ workplace: Psychiatrická klinika IVZ, NsP Ružinov, Bratislava, prednosta MUDr. A. Rakús Published in: Čes. a slov. Psychiat., , 1999, No. 7, pp. 483-488. Category:
Discontinuation syndrome is a syndrome, known by clinicians for severaldecades. The discontinuation syndrome has been observed after abrupt dis-continuation of treatment with inhibitors of monoaminoxidase, tricyclic anti-depressants and serotonin re-uptake inhibitors. The serotonin re-uptakeinhibitor discontinuation syndrome is characterised by signs and symptomsnot present previously. Cluster of five somatic symptoms have been descri-bed: disequilibrium, gastrointestinal symptoms, flu-like symptoms, sensorydisturbances, sleep disturbances. The pharmacologic profile of SSRI playsthe key role in the probability of occurrence of discontinuation syndrome.The long half-life of SSRI may prevent the appearance of discontinuationsyndrome.
Key words: discontinuation syndrome, antidepressants, half-life.
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