Authors: T. Rojkovičová; J. Lehotay; J. Čižmárik 1 Authors‘ workplace: Slovenská technická univerzita v Bratislave, Fakulta chemickej a potravinárskej technológie, Katedra analytickej chémie ; Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra farmaceutickej chémie 1 Published in: Čes. slov. Farm., 2005; 54, 173-177 Category: Original Articles
This paper presents the results obtained with the use of two chiral stationary phases (CSP), based on a glycopeptide antibiotic agent – teicoplanin aglycone (CHIROBIOTIC TAG) and methylated teicoplanin aglycon m-TAG. Twenty-one racemic mixtures of 1-methyl-2-piperidinoethylesters of 2-, 3 - a 4-alkoxyphenylcarbamic acid were examined. The investigation included interaction between separated substances and CSP, and the effect of separation of the enantiomers under study on the value of the resolution factor (Rij) under identical chromatographic conditions with the use of the method of high-performance liquid chromatography (HPLC). On the basis of obtained results, it is possible to report that CSP-CHIROBIOTIC TAG is more advantageous for these racemates, because it does not contain a saccharide part, with decrease the possibility of non-polar interactions which exert a negative effect on the Rij value.
Key words: teicoplanin aglycone - m-TAG – basic derivates of phenylcarbamic acid - HPLC - separation of enantiomers – local anaesthetics
Don‘t have an account? Create new account
Enter the email address that you registered with. We will send you instructions on how to set a new password.
