Authors: M. Stankovičová; Z. Zlevská; Ž. Bezáková; P. Mokrý 1; J. Csöllei 1 Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava ; Ústav chemických léčiv Farmaceutickej fakulty Veterinárnej a farmaceutickej Univerzity, Brno 1 Published in: Čes. slov. Farm., 2005; 54, 23-28 Category: Original Articles
The paper is concerned with the study of adsorption on active charcoal in a set of selected substances from the group of aryloxyaminopropanol derivatives with carbamate substitution on the benzene ring with beta-adrenolytic effect (Group A) and a set of substances, derivatives of [(arylcarbonyl)oxy]aminopropanol with the identical, but assumed ultra-short effect (Group B), where the effect was produced by replacing the phenolether group with a metabolically unstable ester functional group. The course of adsorption in buffer solution with pH 7 in dependence on time and concentration is examined. Adsorptivity of substances is evaluated according to Freundlich and Langmuir models. Affinity of substances of Group A to adsorption material decreases with increasing hydrophilicity.
Key words : adsorption on active charcoal – esters of phenylcarbamic acid – beta-adrenolytic agents – QSAR
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