Adsorption of Substances on Active Charcoal Part 2: Basic Esters of Phenylcarbamic Acid with Beta-adrenolytic Effect


Authors: M. Stankovičová;  Z. Zlevská;  Ž. Bezáková;  P. Mokrý 1;  J. Csöllei 1
Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava ;  Ústav chemických léčiv Farmaceutickej fakulty Veterinárnej a farmaceutickej Univerzity, Brno 1
Published in: Čes. slov. Farm., 2005; 54, 23-28
Category: Original Articles

Overview

The paper is concerned with the study of adsorption on active charcoal in a set of selected substances from the group of aryloxyaminopropanol derivatives with carbamate substitution on the benzene ring with beta-adrenolytic effect (Group A) and a set of substances, derivatives of [(arylcarbonyl)oxy]aminopropanol with the identical, but assumed ultra-short effect (Group B), where the effect was produced by replacing the phenolether group with a metabolically unstable ester functional group. The course of adsorption in buffer solution with pH 7 in dependence on time and concentration is examined. Adsorptivity of substances is evaluated according to Freundlich and Langmuir models. Affinity of substances of Group A to adsorption material decreases with increasing hydrophilicity.

Key words :
adsorption on active charcoal – esters of phenylcarbamic acid – beta-adrenolytic agents – QSAR


Labels
Pharmacy Clinical pharmacology
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