Anticomplementary Activity of Saponins from Cynara cardunculus L.
Authors:
P. Mučaji; M. Bukovský 1; D. Grančai; M. Nagy
Authors‘ workplace:
Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava 1Katedra bunkovej a molekulárnej biológie liečiv Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in:
Čes. slov. Farm., 2003; , 306-309
Category:
Overview
Triterpene saponins of ursane and oleane type isolated from the involucral bracts of Cynaracardunculus L. (Asteraceae) were investigated in in vitro assays for their activity on the complementsystem. The anticomplementary activity of bidesmosidic saponins on the classical pathway activationof the complement was higher than the activity of monodesmosidic saponins, but esterificationof the carboxylic group of glucuronic acid in the sugar residue resulted in a significant decrease inanticomplementary activity.
Key words:
Cynara cardunculus L. – Asteraceae – saponins – triterpenes –anticomplementary activity
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2003 Issue 6
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