Authors: R. Opatřilová; M. Blešová; J. Csöllei Authors‘ workplace: Ústav chemických léčiv Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno Published in: Čes. slov. Farm., 2003; , 136-140 Category:
The paper deals with chromatographic separations of newly prepared substances, aryloxyaminopropanolderivatives. The derivatives represent three homological series of four carbons and fourgroups of positional isomers (methyl - to butyl - in positions 2-, 3, and 4-). Thin-layer adsorptionchromatography employed the foil Silufol® UV 254 as the stationary phase and partition chromatography,commercially produced glass plates DC Fertigplatten MERCK RP-8 F254 S. High-performanceliquid chromatography was used to separate positional isomers on the column SupelkosilTMABZ+PLUS. The mobile phase was methanol and acetonitrile in graded rations with water andvarious flow rates of the mobile phase were tested. Partition chromatography, determination ofpartition coefficient in the system octanol-water, and the values of capacity factors k’ of thesubstances was employed to evaluate their lipophilicity.
Key words: HPLC – TLC – positional isomers – aryloxyaminopropanol – lipophilicity
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