#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

TLC and HPLC Separation of Positional Isomers of Alkylesters of 2-, 3-, 4- {2-Hydroxy-3--[(4-diphenylmethyl)piperazine-1-yl]propoxy}phenylcarbamic Acid and Their Lipo-HydrophilicProperties


Authors: R. Opatřilová;  M. Blešová;  J. Csöllei
Authors‘ workplace: Ústav chemických léčiv Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno
Published in: Čes. slov. Farm., 2003; , 136-140
Category:

Overview

The paper deals with chromatographic separations of newly prepared substances, aryloxyaminopropanolderivatives. The derivatives represent three homological series of four carbons and fourgroups of positional isomers (methyl- to butyl- in positions 2-, 3, and 4-). Thin-layer adsorptionchromatography employed the foil Silufol® UV 254 as the stationary phase and partition chromatography,commercially produced glass plates DC Fertigplatten MERCK RP-8 F254 S. High-performanceliquid chromatography was used to separate positional isomers on the column SupelkosilTMABZ+PLUS. The mobile phase was methanol and acetonitrile in graded rations with water andvarious flow rates of the mobile phase were tested. Partition chromatography, determination ofpartition coefficient in the system octanol-water, and the values of capacity factors k’ of thesubstances was employed to evaluate their lipophilicity.

Key words:
HPLC – TLC – positional isomers – aryloxyaminopropanol – lipophilicity

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Pharmacy Clinical pharmacology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#