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Štúdium reologických vlastností hydrogélov VIVASTARU® P 5000
: Z. Vitková; M. Škarbalová; E. Cirbusová; J. Rak
: Katedra galenickej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava
: Čes. slov. Farm., 2003; , 93-96
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V príspevku sa v rámci predformulačných štúdií hodnotia reologické vlastnosti hydrogélov, ktorýchgélotvornou látkou je polymér, dodaný firmou J. Rettenmaier & SöhneGMBH+CO. Ide o modifikovanýderivát karboxymetylškrobu-VIVASTAR® P 5000. Hodnotili sa reologické vlastnosti hydrogélovo 1,5; 2,0 a 2,5 váh. % VIVASTARu® P 5000. Najvyššiu viskozitu vykazoval hydrogél, v ktorom bola2,0% koncentrácia polyméru. Sústava bez a s modelovou látkou s lokálne anestetickým účinkombola tixotropná. Z hľadiska topickej aplikácie je VIVASTAR® P 5000 v 2,0% koncentrácii optimálnypre formuláciu hydrogélu.
Klíčová slova:
VIVASTAR®P 5000 – hydrogély –modelová látka XXII B – reologické vlastnosti
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Pharmacy Clinical pharmacology
Article was published inCzech and Slovak Pharmacy
2003 Issue 2-
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