Advances in the Development of Antituberculotics Containing No Heterocycles in thePharmacophorePart 1. Carboxylic Acid Derivatives

Authors: K. Waisser;  K. Dražková
Authors‘ workplace: Katedra anorganické a organické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
Published in: Čes. slov. Farm., 2003; , 73-81


The present paper is the twentieth communication in a series of review papers on the developmentof antituberculotics and the ninth communication summarizing the work in the development ofantituberculotics within recent 15 years. The first seven communications were devoted to heterocycliccompounds, the eighth to substances containing an alkylsulfanyl group in the pharmacophore.The present paper summarizes information about cyrboxylic acids, their amides, anilides, hydrazides,thioamides, thioanilides, thiohydrazides, and amidines. The communication includes paperspublished after 1980 in order to link up with a review paper devoted to the same topic published inthe present series in 1982.

Key words:
tuberculostatics – carboxylic acids – mycobacteria – Mycobacterium tuberculosis

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Pharmacy Clinical pharmacology
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