Authors: F. Andriamainty; RIKJ. Čižmá Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava Published in: Čes. slov. Farm., 2001; , 153-155 Category:
We have studied the critical micellar concentration (c.m.c.) of the homologs of the local anestheticheptacaine in the medium 0.1 mol/l NaCl, employing spectrophotometry in the UV region of thespectrum at T=21 °C and pH » 4.5Œ5.0. On the basis of our experimental results, it is assumed thatin the homologous series of amphiphilic compounds the quasi-parabolic dependence of biologicalpotencies on the length of their hydrophobic substituent (—cut-offit effect) could be caused by c.m.c.
Key words: local anesthetic - heptacaine - critical micellar concentration (c.m.c.)
Don‘t have an account? Create new account
Enter the email address that you registered with. We will send you instructions on how to set a new password.
