Effect of Linoleic Acid on the Production of Secondary Metabolites
Authors:
L. Tůmová; J. Dušek
Authors‘ workplace:
Katedra farmakognozie Univerzity Karlovy, Hradec Králové
Published in:
Čes. slov. Farm., 2000; , 78-81
Category:
Overview
The paper examines the effect of linoleic acid in various concentrations on the production offlavonoids in an Ononis arvensis culture in vitro and the production of anthracene derivatives ina Rheum palmatum culture in vitro. The content of the metabolites under study after elicitationwith linoleic acid, which is the precursor of jasminic acid intervening into the course of elicitation,was examined after 12; 24; 48 and 168 hours. The maximal increase in the content of flavonoids(118 %) was found after the application of linoleic acid in a concentration of 2 mg/ml after 48 hrs.In concentrations of 0.01; 0.20, and 1 mg/ml after 48 hours of application of the elicitor, the highestincrease in the content of flavonoids was observed after 24 hrs in a concentration of 2.0 mg/ml. Inthe elicitation of the Rheum palmatum culture, the highest response (100 %) in the production ofanthracene derivatives was observed in linoleic acid in a concentration of 1 mg/ml.
Key words:
elicitor – flavonoids – anthracene derivatives – Rheum palmatum – Ononis arvensis
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2000 Issue 2
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