Determination of Xanthinol Nicotinate in Dosage Forms by Capillary Isotachophoresis
Authors:
M. Pospíšilová; V. Jokl; J. Dolejšová
Authors‘ workplace:
Katedra analytické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
Published in:
Čes. slov. Farm., 2000; , 88-90
Category:
Overview
Cationic capillary isotachophoresis (ITP) with coductimetric detection has been used for separatingand determination of xanthinol in two commercial mass-produced preparations. The optimized ITPelectrolyte system consisted of 5 mM potassium picolinate + 5 mM picolinic acid (pH 5.21) as theleading electrolyte and 10 mM formic acid as the terminating electrolyte. The driving and detectioncurrents were 50 mA (for 380 s) and 10 mA, respectively. The analysis took about 8 min. Accordingto the validation procedure based on the reference UV spectrophotometric method, the ITP methodgave practically the same results.
Key words:
xanthinol – isotachophoresis – pharmaceutical analysis
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2000 Issue 2
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