Ultra-widefield OCTA in Clinical Practice: Expanding Insights into the Peripheral Retina. A Review
Authors:
Filip Kecer 1,2; Jana Štefaničková 2,3; Lucia Štefaničková 1,2; Beáta Bušányová 1; Dana Tomčíková 1
Authors‘ workplace:
Department of pediatric ophthalmology, Faculty of Medicine, Comenius University and National Institute of Children‘s diseases in Bratislava, Slovakia
1; Ophthalmocenter Betliarska, Procare, Bratislava, Slovakia
2; Department of Ophthalmology, Faculty of Medicine, Comenius University and University Hospital Bratislava, Slovakia
3
Published in:
Čes. a slov. Oftal., 82, 2026, No. 5, p. 235-239
Category:
Review
doi:
https://doi.org/10.31348/2026/26
Overview
Ultra-widefield optical coherence tomography angiography represents the latest technological advance that significantly expands the possibilities of non-invasive imaging, not only of retinal and choroidal microcirculation. Compared to conventional OCTA, it enables visualization of the peripheral retina, providing a more comprehensive view of the distribution of vascular changes across a wide spectrum of diseases. In clinical practice, this technology may reduce the need for invasive examinations, particularly fluorescein angiography, or contribute to more accurate identification of patients in whom such examination remains necessary. The aim of this paper is to highlight the clinical application of UWF-OCTA in everyday practice and to demonstrate its benefits based on original imaging material. The study presents typical findings in diabetic retinopathy, central serous chorioretinopathy, pediatric retinal vascular diseases, and vitreoretinal pathologies
Keywords:
Diabetic retinopathy – Ultra-widefield OCTA – peripheral retina – pediatric ophthalmology – peripheral ischemia
Sources
1. Silva PS, Cavallerano JD, Haddad NMN, et al. Peripheral lesions identified on ultrawide field imaging predict increased risk of diabetic retinopathy progression over 4 years. Ophthalmology. 2015 May;122(5):949-956. doi: 10.1016/j.ophtha.2015.01.008
2. Nicholson L, Ramu J, Chan EW, et al. Retinal nonperfusion characteristics on ultra-widefield angiography in eyes with severe nonproliferative diabetic retinopathy and proliferative diabetic retinopathy. JAMA Ophthalmol. 2019 Jun;137(6):626-631. doi: 10.1001/jamaophthalmol.2019.0440
3. Hirano T, Hoshiyama K, Takahashi Y, Murata T. Wide-field swept-source OCT angiography (23 × 20 mm) for detecting retinal neovascularization in eyes with proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2023 Feb;261 : 339-344. doi: 10.1007/s00417-022-05878-1
4. Spaide RF, Fujimoto JG, Waheed NK, Sadda SR, Staurenghi G. Optical coherence tomography angiography. Prog Retin Eye Res. 2018 May;64 : 1-55. doi: 10.1016/j.preteyeres.2017.11.003
5. Cheung CMG, Lee WK, Koizumi H, Dansingani K, Lai TYY, Freund KB. Pachychoroid disease. Eye (Lond). 2019 Jan;33(1):14-33. doi: 10.1038/s41433-018-0158-4
6. Costanzo E, Cohen SY, Miere A, et al. Oubraham H, Souied EH. Optical coherence tomography angiography in central serous chorioretinopathy. J Ophthalmol. 2015;2015 : 134783. doi: 10.1155/2015/134783
7. Spaide RF, Ledesma-Gil G. Choriocapillaris vascular parameters in normal eyes and those with pachychoroid with and without disease. Retina. 2021 Apr;41(4):679-685. doi: 10.1097/ IAE.0000000000002988
8. de Carlo TE, Romano A, Waheed NK, Duker JS. A review of optical coherence tomography angiography (OCTA). Int J Retina Vitreous. 2015 Apr 15;1 : 5. doi: 10.1186/s40942-015-0005-8
9. Corvi F, Pellegrini M, Erba S, Cozzi M, Staurenghi G, Giani A. Reproducibility of quantitative optical coherence tomography angiography parameters in patients with type 1 diabetes. Br J Ophthalmol. 2022 Jun;106(6):826-831. doi: 10.1136/bjophthalmol-2021-318782
10. López-Cañizares A, Lazzarini TA, Mendoza C, Berrocal AM. Familial exudative vitreoretinopathy (FEVR) in a child with novel microarray-defined deletion of 11q14 previously diagnosed as retinopathy of prematurity. Ophthalmic Genet. 2022 Nov;43(6):1-5. doi: 10.1080/13816810.2022.2116648
11. Ranchod TM, Ho LY, Drenser KA, Capone A Jr, Trese MT. Clinical presentation of familial exudative vitreoretinopathy. Ophthalmic Surg Lasers Imaging Retina. 2013 Nov-Dec;44(6):577-584. doi: 10.3928/23258160-20131015-04
12. Gilmour DF. Familial exudative vitreoretinopathy and related retinopathies. Eye (Lond). 2015 Jan;29(1):1-14. doi: 10.1038/ eye.2014.70
13. Tarkkanen A, Laatikainen L. Coat’s disease: clinical, angiographic, histopathological findings and clinical management. Br J Ophthalmol. 1983 Nov;67(11):766-776. doi: 10.1136/bjo.67.11.766
14. Chang MM, McLean IW, Merritt JC. Coats’ disease: a study of 62 histologically confirmed cases. J Pediatr Ophthalmol Strabismus. 1984 Sep–Oct;21(5):163-168. doi: 10.3928/0191-3913-19840901-03
15. Ashkenazy N, Acon D, Kalavar M, Berrocal AM. Optical coherence tomography angiography and multimodal imaging in the management of Coats’ disease. Am J Ophthalmol Case Rep. 2021 Jul 24;23 : 101177. doi: 10.1016/j.ajoc.2021.101177
16. Rabiolo A, Marchese A, Sacconi R, et al. Refining Coats’ disease by ultra-widefield imaging and optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol. 2017 Oct;255(10):1881 - 1890. doi: 10.1007/s00417-017-3794-7
Labels
OphthalmologyArticle was published in
Czech and Slovak Ophthalmology
2026 Issue 5
-
All articles in this issue
- Hyperreflective Outer Nuclear Layer as a Biomarker of Early Stargardt Disease. A Case Report
- Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness Analysis in Treatment – Naive Glaucoma Patients
- Customized Cryotherapy for Ocular Salvage in Descemetocele and Iris Prolapse: A 17-Year Retrospective Study
- The Role of Prophylactic Topical Administration of Antibiotics in Uncomplicated Cataract Surgery in the Era of Intracameral Antibiotics. Opinion Article
- Evaluation of the Effects of Intravitreal Application of the Ozurdex Implant in Patients with Macular Edema due to Retinal Vein Occlusion
- Ultra-widefield OCTA in Clinical Practice: Expanding Insights into the Peripheral Retina. A Review
- Vzpomínka na prof. MUDr. Jaroslava Řehůřka, CSc.
- Czech and Slovak Ophthalmology
- Journal archive
- Current issue
- Online only
- About the journal
Most read in this issue
- Evaluation of the Effects of Intravitreal Application of the Ozurdex Implant in Patients with Macular Edema due to Retinal Vein Occlusion
- Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness Analysis in Treatment – Naive Glaucoma Patients
- The Role of Prophylactic Topical Administration of Antibiotics in Uncomplicated Cataract Surgery in the Era of Intracameral Antibiotics. Opinion Article
- Customized Cryotherapy for Ocular Salvage in Descemetocele and Iris Prolapse: A 17-Year Retrospective Study