Intrinsically Photosensitive Retinal Ganglion Cells
Authors:
K. Skorkovská 1; Š. Skorkovská 2
Authors‘ workplace:
Klinika nemocí očních a optometrie, Lékařská fakulta Masarykovy univerzity Fakultní nemocnice u sv. Anny, Brno
přednosta doc. MUDr. Svatopluk Synek, CSc.
1; Evropská oční klinika Lexum, Bezručova 22, Brno
2
Published in:
Čes. a slov. Oftal., 71, 2015, No. 3, p. 144-149
Category:
Original Article
Overview
Recently discovered intrinsically photosensitive melanopsin-containing retinal ganglion cells contribute to circadian photoentrainment and pupillary constriction; recent works have also brought new evidence for their accessory role in the visual system in humans. Pupil light reaction driven by individual photoreceptors can be isolated by means of the so called chromatic pupillography. The use of chromatic stimuli to elicit different pupillary responses may become an objective clinical pupil test in the detection of retinal diseases and in assessing new therapeutic approaches particularly in hereditary retinal degenerations like retinitis pigmentosa. In advanced stages of disease, the pupil light reaction is even more sensitive than standard electroretinography for detecting residual levels of photoreceptor activity. This review summarizes current knowledge on intrinsically photosensitive retinal cells and highlights its possible implications for clinical practice.
Key words:
retinal ganglion cells, melanopsin, pupillography, retinitis pigmentosa
Sources
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Labels
OphthalmologyArticle was published in
Czech and Slovak Ophthalmology
2015 Issue 3
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