#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

The Potential use of Honey in Ophthalmology


Authors: N. Majtánová 1;  M. Černák 1;  J. Nekorancová 1;  A. Černák 1;  J. Majtán 2,3
Authors‘ workplace: Očné oddelenie, Lekárska fakulta, Slovenská zdravotnícka univerzita, Bratislava, Slovensko, vedúci oddelenia prof. MUDr. Andrej Černák, DrSc. 1;  Ústav zoológie, Slovenská akadémia vied, Bratislava, Slovensko, riaditeľ RNDr. Milan Kozánek, CSc. 2;  Oddelenie mikrobiológie, Lekárska fakulta, Slovenská zdravotnícka univerzita, Bratislava, Slovensko, vedúci oddelenia doc. RNDr. Viktor Majtán, CSc. 3
Published in: Čes. a slov. Oftal., 69, 2013, No. 3, p. 128-132
Category: Original Article

Overview

Honey is considered to be a natural product with antibacterial and anti-inflammatory properties. Its successful application in the treatment of chronic wounds and burns has promoted its further clinical use in other clinical departments, including ophthalmology. One of the major advantages of honey is its multi-factorial antibacterial action and the fact that there is no risk of developing bacterial resistance to it.

In this work we discuss the current knowledge and new perspectives for honey therapy in treatment of eye diseases such as dry eye disease, age-related macular degeneration, cataracts and bullous keratopathy.

Key words:
honey, eye diseases, natural product, treatment


Sources

1. Al–Waili, N.S.: Investigating the antimicrobial activity of natural honey and its effects on the pathogenic bacterial infections of surgical wounds and conjunctiva. J Med Food, 7; 2004: 210–222.

2. Albietz, J.M., Bruce, A.S.: The conjunctival epithelium in dry eye subtypes: effect of preserved and non–preserved topical treatments. Curr Eye Res, 22; 2001: 8–18.

3. Albietz, J.M., Lenton, L.M.: Effect of antibacterial honey on the ocular flora in tear deficiency and meibomian gland disease. Cornea, 25; 2006: 1012–1019.

4. Alvarez–Suarez, J.M., Giampieri, F., Battino, M. Honey as a source of dietary antioxidants: structures, bioavailability and evidence of protective effects against human chronic diseases. Curr Med Chem, 20; 2013: 621–638.

5. Bashkaran, K., Zunaina, E., Bakiah, S. et al.: Anti–inflammatory and antioxidant effects of Tualang honey in alkali injury on the eyes of rabbits: experimental animal study. BMC Complement. Altern. Med, 2011; 11: 90.

6. Benz, M.S., Scott, I.U., Flynn Jr, H.W. et al.: Endophthalmitis isolates and antibiotic sensitives: a 6 year review of culture–proven cases. Am J Ophthalmol, 137; 2004: 38–42.

7. Blanco, A.R., Sudano–Roccaro, A., Spoto, G.C. et al.: Epigallocatechin galltae inhibits biofilm formation by ocular Staphylococcal isolates. Antimicrob Agents Chemother, 49; 2005: 4339–4343.

8. Cernak, M., Majtanova, N., Cernak, A. et al.: Honey prophylaxis reduces the risk of endophthalmitis during perioperative period of eye surgery. Phytother Res, 26; 2012: 613–616.

9. Cornish, K.M., Williamson, G., Sanderson, J.: Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. Free Radical Biol Med, 33; 2002: 63–70.

10. Crandall, A.S., Raber, I., Teske, M.P. et al.:. Ophthalmology: Diseases of the eye. In: Lawrence PF, editor. Essentials of surgical specialties. Third ed. Philadelphia: Lippincott Williams & Wilkins; 2007, p. 467.

11. Cushnie, T.P., Lamb, A.J. Antimicrobial activity of flavonoids. Int. J. Antimicrob. Agents, 26; 2005: 343–356.

12. De Saint Jean, M., Brignole, P., Bringuier, A.F. et al.: Effects of benzalkonium chrloride on growth and survival of Chang conjuctival cells. Invest Ophthalmol Visual Sci, 40; 1999: 619–630.

13. De Santis, L. New horizons in the medical therapy of cataract: aldose reductase inhibitors and other agents. Pharmacology International, 7; 1986: 17–20.

14. Eye Disease Prevalence Group Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol, 122; 2004: 564–572.

15. Henriques, A., Jackson, S., Cooper, R. et al.: Free radical production and quenching in honeys with wound healing potential. J Antimicrob Chemother, 58; 2006: 773–777.

16. Hori, Y., Maeda, N., Sakamoto, M. et al.: Fluoroquinolone-resistant bacteria and methicillin-resistant Staphylococci from normal preoperative conjunctiva. J Cataract Refract Surg, 34; 2008: 711–712.

17. Hori, Y., Maeda, N., Sakamoto, M. et al.: Bacteriologic profile of the conjunctiva in the patients with dry eye. Am J Ophthalmol, 146; 2008: 729–734.

18. Chen, Y., Li, X.X., Xing, N.Z. et al.: Quercetin inhibits choroidal and retinal angiogenesis in vitro. Graefes Arch Clin Exp Ophthalmol, 246; 2008: 373–378.

19. Jankauskiene, J., Jarushaitiene, D., Cheksteryte, V. et al.: Using 20% honey solution eye drops in patients with dry eye syndrome. J Apic Res, 46; 2007: 232–235.

20. Kawanishi, K., Ueda, H., Moriyasu, M. Aldose reductase inhibitors from the nature. Curr Med Chem, 10; 2003: 1353–1374.

21. Knezovic, I., Dekaris, I., Gabric, N. et al.: Therapeutic efficacy of 5% NaCl hypertonic solution in patients with bullous keratopathy. Coll Antropol, 30; 2006: 405–408.

22. Kwakman, P.H., Te Velde, A.A., De Boer, L. et al.: Two major medicinal honeys have different mechanisms of bactericidal activity. PLoS ONE, 6; 2011: e17709.

23. Lemp, M.A. Management of dry eye disease. Am. J. Manag. Care, 14, 2008, S88–S101.

24. Leong, A.G., Herst, P.M., Harper, J.L. Indigenous New Zealand honeys exhibit multiple anti–inflammatory activities. Innate Immun, 18; 2012: 459–466.

25. Majumdar, S., Srirangam, R. Potential of the bioflavonoids in the prevention/treatment of ocular disorders. J Pharm Pharmacol, 62; 2010: 951–965.

26. Mansour, A.M. Epithelial corneal oedema treated with honey. Clin Experiment Ophthalmol, 30; 2002: 149–150.

27. Mansour, A.M., Zein, W., Haddad, R. et al.: Bullous keratopathy treated with honey. Acta Ophthalmol Scand, 82; 2004: 312–313.

28. Miller, D., Flynn, P.M., Scott, I.U. et al.: In vitro fluoroquinolone resistance in staphylococcal endophthalmitis isolates. Arch Ophthalmol, 124; 2006: 479–483.

29. Miyanaga, M., Nejima, R., Miyai, T. et al.: Changes in drug susceptibility and the quinolone–resitance determining region of Staphylococcus epidermidis after administration of fluoroquinolones. J Cataract Refract Surg, 35; 2009: 1970–1978.

30. Mozherenkov, V.P., Prokofjeva, G.L. Apiterpiia glaznykh zabolevanii. Apitherapy of eye diseases. Vestn Oftalmol, 107; 1991: 73–75.

31. Okuda, J., Miwa, I., Inagaki, K. et al.: Inhibition of aldose reductases from rat and bovine lenses by flavonoids. Biochem Pharmacol, 31; 1982: 3807–3822.

32. Park, S.H., Lim, J.A., Choi, J.S. et al.: The resistance patterns of normal ocular bacterial flora to 4 fluoroquinolone antibiotics. Cornea, 28; 2009: 68–72.

33. Rhone, M., Basu, A. Phytochemicals and age–related eye diseases. Nutr Rev, 66; 2008: 465–472.

34. Sethi, H.S., Rai, H.K. Bullous keratopathy treated with honey. Acta Ophthalmol. Scand., 83; 2005: 263–263.

35. Shimizu, M., Ito, T., Terashima, S. et al.: Inhibition of lens aldose reductase by flavonoids. Phytochemistry, 23; 1984: 1885–1888.

36. Shimmura, S., Shimazaki, J., Tsubota, K. Results of population-based questionnaire on the symptoms and lifestyles associated with dry eye. Cornea, 18; 1999: 408–411.

37. Tonks, A.J., Dudley, E., Porter, N.G. et al.: A 5.8–kDa component of manuka honey stimulates immune cells via TLR4. J Leukoc Biol, 82; 2007: 1147–1155.

38. Tsai, T.H., Chen, W.L., Hu, F.R. Comparison of fluoroquinolones: cytotoxicity on human corneal epithelial cells. Eye, 24; 2010: 909–917.

39. Uwaydat, S., Jha, P., Tytarenko, R. et al.: The use of topical honey in the treatment of corneal abrasions and endotoxin–induced keratitis in an animal model. Curr Eye Res, 36; 2011: 787–796.

40. van den Berg, A.J., van den Worm, E., van Ufford, H.C. et al.: An in vitro examination of the antioxidant and anti–inflammatory properties of buckwheat honey. J. Wound Care, 17; 2008: 172–178.

41. Varma, S.D., Kinoshita, J.H. Inhibition of lens aldose reductase by flavonoids – their possible role in the prevention of diabetic cataracts. Biochem Pharmacol, 25; 1976: 2505–2513.

42. Varma, S.D., Mizuno, A., Kinoshita, J.H. Diabetic cataracts and flavonoids. Science, 195; 1977: 205–206.

43. Vikram, A., Jayaprakasha, G.K., Jesudhasan, P.R. et al.: Suppression of bacterial cell–cell signalling, biofilm formation and type III secretion system by citrus flavonoids. J Appl Microbiol, 109; 2010: 515–527.

44. Vit, P., Jacob, T.J. Putative anticataract properties of honey studied by the action of flavonoids on a lens culture model. J. Health Sci, 54; 2008: 196–202.

45. West, E.S.B., A, McDonnell, P.J., Tielsch, J.M. et al.: The increase of endophtalmitis after catarct surgery among the U.S. Medicare population increased between 1994 and 2001. Ophthalmology, 112; 2005: 1388–1394.

46. Zou, Y., Chiou, G.C. Apigenin inhibits laser-induced choroidal neovascularization and regulates endothelial cell function. J Ocul Pharmacol Ther, 22; 2006: 425– 430.

Labels
Ophthalmology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#