Authors: J. Veselovský 1; Z. Oláh 2; A. Veselá 1; S. Gressnerová 1 Authors‘ workplace: Katedra živočíšnej fyziológie a etológie PriF UK, Bratislava, SR, vedúci doc. RNDr. M. Zeman, DrSc. 2Klinika oftalmológie LF UK, Bratislava, SR, prednosta prof. MUDr. P. Strmeň, CSc. 1 Published in: Čes. a slov. Oftal., , 2004, No. 5, p. 319-327 Category:
Authors present results of series of experiments focused to influence the IOP byantiglaucomatics in rabbits (New Zealand White) with physiological IOP. Addingof the 10% amino acid L-arginin.HCl to the 0.005% Xalatan eye drops intensifiesactivity of antiglaucomatics resulting in 9.5% average reduction of the IOP ina four-hour experiments (with maximum in 15th min. - 19.3%), compared withapplication of both substances alone. Size of the pupil was not affected. Based onour experimental results we assume that the increased activity of the 0.005%Xalatan mixture with 10% amino acid L-arginin.HCl created a new completemetabolite – „bio-antiglaucomaticum“. According to our observations this metabolitecaused increase of the uveo-scleral outflowleading to the striking reductionof the physiological IOP in rabbits.
Key words: IOP after local application of the amino acid 10% L-arginin.HCl and0.005% Xalatan mixture in experiments. New metabolite – „bio-antiglaucomaticum“and the physiologic IOP in rabbits
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