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Clinical Oncology - Issue Supplementum 1/2016

Editorial

3

Review

9

Recommended Extension of Indication Criteria for Genetic Testing of BRCA1 and BRCA2 Mutations in Hereditary Breast and Ovarian Cancer Syndrome

L. Foretová, E. Macháčková, M. Palacova, M. Navratilova, M. Svoboda, K. Petrakova

14

Hereditary Breast and Ovarian Cancer Syndrome

K. Petrakova, M. Palacova, M. Schneiderová, M. Standara

22

Gynecological Care and Prevention of Gynecological Malignancies in BRCA1 and BRCA2 Mutation Carriers

Michal Zikán

55

Genetics of Colorectal Tumorigenesis (Possibilities of Testing and Screening Prediction of Hereditary Form of Colorectal Cancer – Lynch Syndrome)

I. Mľkvá

62

Syndromes Predisposing to Cancer in Children – the Experience of Pediatric Oncology Departmentof University Hospital Brno

V. Bajčiová

71

Genetic Syndromes Predisposing to Tumors of Central Nervous System in Children

V. Krutílková

78

Hepatoblastoma, Etiology, Case Reports

A. Puchmajerová, A. Křepelová, J. Indráková, R. Sítková, I. Balaščak, J. Kruseová, K. Švojgr, R. Kodet, M. Kynčl, A. Vícha, M. Macek Jr.

Original Articles

31

PALB2 as Another Candidate Gene for Genetic Testing in Patients with Hereditary Breast Cancer in Czech Republic

M. Janatová, M. Borecká, J. Soukupová, P. Kleiblová, J. Stříbrná, M. Vočka, P. Zemánková, A. Panczak, K. Veselá, P. Souček, L. Foretová, Z. Kleibl

35

Retrospective NGS Study in High-risk Hereditary Cancer Patients at Masaryk Memorial Cancer Institute

E. Macháčková, J. Hazova, E. Sťahlová Hrabincová, P. Vašíčková, M. Navratilova, M. Svoboda, L. Foretová

46

CZECANCA: CZEch CAncer paNel for Clinical Application – Design and Optimization of the Targeted Sequencing Panel for the Identification of Cancer Susceptibility in High-risk Individuals from the Czech Republic

J. Soukupová, P. Zemánková, P. Kleiblová, M. Janatová, Z. Kleibl

Case Report

83

Identification of a Family with SUFU Germline Deletion Based on a Case of Desmoplastic Medulloblastoma in an Infant

J. Šoukalová, K. Vejmělková, T. Cermanová, K. Kašíková, A. Mikulášová, H. Janyšková, K. Melichárková, Z. Pavelka, Marta Ježová, Š. Pospíšilová, P. Kuglík, I. Valášková, R. Gaillyová, J. Štěrba, K. Zitterbart

89

Fanconi Anemia, Complementation Group D1 Caused by Biallelic Mutations of BRCA2 Gene – Case Report

A. Puchmajerová, K. Švojgr, D. Novotná, E. Macháčková, D. Sumerauer, P. Smíšek, R. Kodet, M. Kynčl, A. Křepelová, L. Foretová

Clinical Oncology

Issue Supplementum 1

2016 Issue Supplementum 1

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