Authors: F. Kohútek 1; A. Rosík 1; N. Izák 2; M. Tamášová 3; B. Bystrický 1 Authors‘ workplace: Onkologické oddelenie, FN Trenčín, Slovensko 1; Magnetická rezonancia FUTURUM s. r. o., Trenčín, Slovensko 2; Klinika pneumológie a ftizeológie LF UK a UN Bratislava, Slovensko 3 Published in: Klin Onkol 2014; 27(4): 287-290 Category: Case Report
Background: Paraneoplastic syndromes precede the diagnosis of malignancy. Early detection of paraneoplastic syndrome may lead to detection of malignancy in its early and potencially curable stage. Differential diagnostic process of rare paraneoplastic vasculitis requires multidisciplinar cooperation between rheumatologists, radiologists and oncologists.
Case: 41‑year ‑ old female patient with cervical cancer in stage IVB (paraaortic lymphadenopathy) and clinical symptoms of acute vasculitis was admitted to our ward for oncological treatment. Chemoradiotheraphy was initiated concurently with corticotherapy. During the treatment we observed alleviation of vasculitis‑related symptoms. Ongoing follow‑up, however, brought no further improvement in vasculitis‑related symptoms. This lead us to suspiction of recurrence, confirmed on CT scan. Paliative chemotherapy was without any effect and due to worsening performance status was terminated.
Conclusion: The activity of vasculitis was closely associated with the activity of primary malignant disease. Early recognition of paraneoplastic syndrome may contribute not only to diagnosis of malignancy, but is helpfull during follow‑up of these patients.
Key words: cervical cancer – paraneoplastic syndrome – vasculitis – angiography The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Submitted: 14. 6. 2014
Accepted: 6. 7. 2014
1. Adam Z, Chlupová G et al. Systémové a paraneoplastické projevy maligních onemocnení. Vnitř Lék 2007; 53(3): 253 – 285.
2. Jennette JC, Falk RJ, Bacon PA et al. 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 2013; 65(1): 1 – 11. doi: 10.1002/ art.37715.
3. Solans ‑ Laqué R1, Bosch ‑ Gil JA, Pérez ‑ Bocanegra C et al. Paraneoplastic vasculitis in patients with solid tumors: report of 15 cases. J Rheumatol 2008; 35(2): 294 – 304.
4. Bečvář R, Rovenský J. Sekundárne vaskulitídy pri systémových ochoreniach spojivového tkaniva a poliekové vaskulitídy. Vaskulárna medicína 2010; 2(3): 120 – 126.
5. Mukhtyar C, Guillevin L, Cid MC et al. EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis 2009; 68(3): 310 – 317. doi: 10.1136/ ard.2008.088096.
6. NCCN.org [homepage on the Internet]. Clinical practice guidelines in oncology: cervical cancer. National Comprehensive Cancer Network; 2013 [cited 2013 Nov 1]. Available from: http:/ / www.nccn.org/ professionals/ physician_gls/ pdf/ cervical.pdf.
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