#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

New and Clinically Used Oncomarkers of Bladder Cancer


Authors: M. Bilecová-Rabajdová 1;  J. Varga 2;  P. Urban 1;  A. Ostró 2;  M. Pilátová 3;  M. Mareková 1
Authors‘ workplace: Ústav lekárskej a klinickej biochémie a Labmed, a. s., LF UPJŠ Košice, Slovenská republika 1;  II. gynekologicko-pôrodnícka klinika, LF UPJŠ Košice, Slovenská republika 2;  Ústav farmakológie, LF UPJŠ Košice, Slovenská republika 3
Published in: Klin Onkol 2012; 25(3): 162-165
Category: Reviews

Overview

Bladder cancer is the fourth most common cancer in men and the eighth most common cancer in women. Oncomarkers play a crucial role in early detection of bladder cancer, as well as in treatment response monitoring and prognosis. Search for a new marker by molecular analysis is in progress because any diagnostic sensitivity and specificity enhancement is a great benefit for clinical practice.

Key words:
bladder cancer – tumor markers – molecular diagnostics

This study was supported by grant VEGA 1/0102/10.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
22. 12. 2011

Accepted:
12. 4. 2012


Sources

1. Litwack G. Human biochemistry and disease. Stratford: Academic press Elsevier 2008: 570–573.

2. Kindlová E, Kovařík J, Kubecová M et al. Orgán záchovný postup v léčbě invazivního karcinomu močového měchýře. Vybrané otázky onkologie VI. Praha: Galén 2002: 36–39.

3. Kwon IK, Schoenlein PV, Delk J et al. Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis. Cancer 2008; 112(7): 1462–1470.

4. Pallis AG, Fennell DA, Szutowicz E et al. Biomarkers of clinical benefit for anti-epidermal growth factor receptor agents in patients with non-small-cell lung cancer. Br J Cancer 2011; 105(1): 1–8.

5. Rosser CJ, Liu L, Sun Y et al. Bladder cancer-associated gene expression signatures identified by profiling of exfoliated urothelia. Cancer Epidemiol Biomarkers Prev 2009; 18(2): 444–453.

6. Bartels CL, Tsongalis GJ. MicroRNAs: novel biomarkers for human cancer. Clin Chem 2009; 55(4): 623–631.

7. Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer. Nat Rev Cancer 2002; 2(5): 331–341.

8. Stenvang J, Silahtaroglu AN, Lindow M et al. The utility of LNA in microRNA-based cancer diagnostics and therapeutics. Semin Cancer Biol 2008; 18(2): 89–102.

9. Soker S, Takashima S, Miao HQ et al. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998; 92(6): 735–745.

10. Shahzad MM, Arevalo JM, Armaiz-Pena GN et al. Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis. J Biol Chem 2010; 285(46): 35462–35470.

11. Abogunrin F, O’Kane HF, Ruddock MW et al. The impact of biomarkers in multivariate algorithms for bladder cancer diagnosis in patients with hematuria. Cancer 2012; 118(10): 2641–2650.

12. Hegele A, Mecklenburg V, Varga Z et al. CA19.9 and CEA in transitional cell carcinoma of the bladder: serological and immunohistochemical findings. Anticancer Res 2010; 30(12): 5195–5200.

13. Kundal VK, Pandith AA, Hamid A et al. Role of NMP22 Bladder Check Test in early detection of bladder cancer with recurrence. Asian Pac J Cancer Prev 2010; 11(5): 1279–1282.

14. Mizutani Y, Matsubara H, Yamamoto K et al. Prognostic significance of serum osteoprotegerin levels in patients with bladder carcinoma. Cancer 2004; 101(8): 1794–1802.

15. Benchop R, Grewal S. Therapeutic targets of the TNF superfamily. New York: Springer 2009: 186–195.

16. Reid PE, Brown NJ, Holen I. Breast cancer cells stimulate osteoprotegerin (OPG) production by endothelial cells through direct cell contact. Mol Cancer 2009; 8: 49.

17. Kwon IK, Thangaraju M, Shuang H et al. PKG inhibits TCF signaling in colon cancer cells by blocking β-catenin expression and activating FOXO4. Oncogene 2010; 29(23): 3423–3434.

18. Seaman S, Stevens J, Yang MY. Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 2007; 11(6): 539–554.

19. Stephenson JM, Banerjee S, Saxena NK et al. Neuropilin-1 is differentially expressed in myoepithelial cells and vascular smooth muscle cells in preneoplastic and neoplastic human breast: a possible marker for the progression of breast cancer. Int J Cancer 2002; 101(5): 409–414.

20. Oliveira PA, Colaço A, Chaves R et al. Chemical carcinogenesis. Biomedical and medical sciences. An Acad Bras Cienc 2007; 79(4): 3761–3765.

21. Vasala K, Kuvaja P, Turpeenniemi-Hujanen T. Low circulating levels of ProMMP-2 are associated with adverse prognosis in bladder cancer. Tumour Biol 2008; 29(5): 279–286.

22. Shinkaruk S, Bayle M, Laïn G et al. Vascular endothelial cell growth factor (VEGF), an emerging target for cancer chemotherapy. Curr Med Chem Anticancer Agents 2003; 3(2): 95–117.

Labels
Paediatric clinical oncology Surgery Clinical oncology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#