Authors: R. Lakomý 1,2; P. Burkoň 1,3; D. Burkoňová 1,3; R. Jančálek 1,4 Authors‘ workplace: Lékařská fakulta, Masarykova univerzita Brno 1; Klinika komplexní onkologické péče, Masarykův onkologický ústav, Brno 2; Klinika radiační onkologie, Masarykův onkologický ústav, Brno 3; Neurochirurgická klinika, FN u sv. Anny v Brně 4 Published in: Klin Onkol 2010; 23(6): 381-387 Category: Reviews
Glioblastoma multiforme is one of the most aggressive malignant brain tumours with limited therapeutics options. Standard therapy is maximal surgical resection and adjuvant concurrent chemo ‑ radiotherapy and maintenance therapy with temozolomide. This approach improves median and 5‑year survival in comparison with postsurgical radiotherapy alone. Additional predictive and prognostic biomarkers are necessary, especially due to the development of targeted therapy – antibodies and tyrosine kinase inhibitors. These new therapeutic approaches are under intensive investigation. The most promising data currently available are for anti‑angiogenic therapies, such as bevacizumab and cediranib. This review presents a summary of the possible role of targeted therapy in the treatment of glioblastoma multiforme.
Key words: glioblastoma multiforme – targeted therapy – biomarkers – angiogenesis – VEGF – EGFR – integrins
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