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Calprotectin in the stool -⁠ Problems of determination (short communication)


Authors: B. Friedecký
Published in: Klin. Biochem. Metab., 34, 2026, No. 3, p. 0

Overview

The large number of methods used for very different analytical principles and on the other hand a very low level of standar -⁠ dization is the reason for extremely high differences in faecal calprotectine measurement. These differences are observed not only in external quality assessment programs, but in all published studies of comparability and validation. As opposed to this fact, the majority of publications and working sheets introduce very similar diagnostic decision limits values for this test. Several sophisticated publications on the guidance or consensus for measurement and results interpretation are for disposition, but their influence on the routine performances is negligible. We can say that the situation in measurement of analytes using the many possible methods, but minimal level of standardization is in sharp discrepancy with interoperability as a clear trend of contemporary laboratory medicine.

Keywords:

EQA – standardization – calprotectine – faeces – measurement methods – interoperability


Sources

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