Authors: B. Friedecký 1,2,*; J. Kratochvíla 2 Authors‘ workplace: ÚKBD Fakultní nemocnice Hradec Králové 1; SEKK spol. s. r. o., Pardubice 2 Published in: Klin. Biochem. Metab., 31, 2023, No. 1, p. 5-8 doi: https://doi.org/10.61568/kbm.2023.002
This brief note describes current state of analytical quality and comparability of various systems for continuous glucose monitoring (CGM). An overview of seven basic CGM parameters targeted to evaluation of monitoring results is given. Analytical variability of measurement, state of requirements for CGM, state of standardization, outlooks of its further development, and basic limits of its implementation are presented. CGM results depend of sensor type more than what would be desirable for patients monitoring. Despite the fact that analytical parameters of CGM systems are gradually improving, standardization and metrological traceability of calibration to a reference measurement system are still needed. A key problem is the use of interstitial fluid (ISF) as a sample matrix as well as absence of reference method of glucose measurement in it. Current working group for CGM (IFCC-CGM) intends to deal with: (1) problems of this standardization, (2) establishing criteria for acceptable analytical quality, and (3) producing an international recommendation for CGM measurement.
metrological traceability – rt-CGM – isCGM – MARD – comparability
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