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MicroRNA biomarkers in the diagnosis of oncological cardiotoxicity


Authors: P. Kušnierová 1,2,*;  Z. Švagera 1,2;  O. Michnová 1;  M. Hložánková 3;  P. Kosztyu 3;  L. Chalupová 3;  B. Dvořáková 3;  V. Seidlová 3;  R. Petr 4;  J. Knot 4;  R. Koževnikovová 5;  J. Cvek 6;  D. Stejskal 1,2
Authors‘ workplace: Ústav laboratorní medicíny, Oddělení klinické biochemie, Fakultní nemocnice Ostrava, Ostrava 1;  Ústav laboratorní medicíny, Lékařská fakulta, Ostravská univerzita, Ostrava 2;  BioVendor - Laboratorní medicína a. s., Brno 3;  Kardiologie Praha s. r. o., Praha 4;  Medicon a. s., Praha 5;  Klinika onkologická, Lékařská fakulta, Ostravská univerzita a Fakultní nemocnice Ostrava, Ostrava 6
Published in: Klin. Biochem. Metab., 31, 2023, No. 1, p. 16-20
doi: https://doi.org/10.61568/kbm.2023.004

Overview

MicroRNAs are very stable short (18-24) noncoding RNAs. The function of miRNA molecules includes everything from the regulation of key signalling pathways at the molecular level to the rapid cellular response to pathological conditions. miRNAs are stable in body fluids and represent a very promising diagnostic targets for the early identification of a wide range of diseases. This summary article provides an overview of candidate diagnostic miRNAs suitable for use in the diagnosis of oncological cardiotoxicity.

Keywords:

cardiotoxicity – microRNA – oncology


Labels
Clinical biochemistry Nuclear medicine Nutritive therapist
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