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Diagnosis and stratification of systemic AL amyloidosis in the light of the 2013 Czech Myeloma Group recommendation


Authors: V. Ščudla 1;  T. Pika 1;  P. Látalová 2;  P. Flodr 2;  V. Maisnar 3;  R. Hájek 4;  Česká Myelomová Skupina
Authors‘ workplace: III. interní klinika-revmatologická, nefrologická a endokrinologická LF UP a FN, Olomouc 1;  Ústav klinické a molekulární patologie LF UP a FN, Olomouc 2;  IV. Interní hematologická klinika LF UK a FN, Hradec Králové 3;  Klinika hematoonkologie LF OU a FN, Ostrava 4
Published in: Klin. Biochem. Metab., 22 (43), 2014, No. 2, p. 49-60

Overview

The paper is concerned with classification of amyloidosis and presenting clinical manifestations, examination methods and an effective diagnostic algorithm related to systemic AL amyloidosis. Greater attention is paid to current investigation techniques and their role in the differential diagnosis and stratification of systemic AL amyloidosis as a starting point for prognostic prediction and individual selection of therapy. The review has been prepared in the light of the 2013 Czech Myeloma Group recommendations “Diagnosis and Treatment of Systemic AL Amyloidosis”.

Key words:
classification of amyloidosis, systemic AL amyloidosis, diagnostic algorithm, differential diagnosis, prognostic stratification.


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