Authors: Z. Vitková; M. Škarbalová; E. Cirbusová; J. Rak Authors‘ workplace: Katedra galenickej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava Published in: Čes. slov. Farm., 2003; , 93-96 Category:
Within the framework of pre-formulation studies, the paper evaluates the rheological properties ofhydrogels whose gel-forming substance is a polymer supplied by the firm J. Rettenmaier &SöhneGMBH+CO. It is VIVASTAR® P 5000, a modified derivate of carboxymethyl starch. The evaluationof rheological properties included hydrogels with 1.5, 2.0 and 2.5 w % of VIVASTAR® P 5000.The highest viscosity was shown by the hydrogel with 2.0% concentration of the polymer. The systemwithout and with the model drug with a local anaesthetic effect was thixotropic. From the viewpointof topical administration, VIVASTAR® P 5000 in 2.0% is optimal for hydrogel formulation.
Key words: VIVASTAR® P 5000 – hydrogels – model drug XXII B – rheological properties
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