Authors: O. Viklický; I. Matl; J. Lácha Authors‘ workplace: Klinika nefrologie - Transplantační centrum IKEM, Praha 1 Semmelweisova Universita, Budapešť, Maďarsko 2 Nefrologické oddělení, Univerzitní klinika, Essen, SRN Published in: Čas. Lék. čes. 2000; : 524-528 Category:
Chronic rejection represents an important cause of renal allograft loss in the long term follow up. New insightsinto etiopathogenesis of the chronic rejection offer possibilities for experimental therapy. Novel immunosuppressants,such as mycophenolic acid, tacrolimus or rapamycin as well as lipid lowering drugs, angiotensin-converting enzymeinhibitors or AT-1 receptor blockers, may reduce of effects the risk factors on the progression of chronic rejection.In the future, gene therapy may offer additional possibilities to prevent chronic rejection. This review deals withpossibilities of prevention of the chronic renal allograft rejection based on experimental evidences and currenttherapeutic concepts and puts these options into a rational perspective.
Key words: renal transplantation, chronic rejection, experimental therapy, immunosuppression.
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