Coeliac disease

Czech version

Authors: Přemysl Falt ^1,2; P. Fojtík ¹; V. Šmajstrla ¹
Authors‘ workplace: Centrum péče o zažívací trakt, Vítkovická nemocnice, Ostrava ¹; LF OU v Ostravě ²
Published in: Kardiol Rev Int Med 2014, 16(3): 219-223
Category: Internal Medicine

Overview

Coeliac disease is a common lifelong autoimmune disorder triggered by gluten consumption in genetically predisposed patients. Chronic inflammatory response damages the mucosa of the small intestine resulting in villous atrophy with chronic maldigestion and malabsorption. Untreated coeliac disease may present with a variety of intestinal and extraintestinal symptoms and complications, the most serious of which is a small intestine lymphoma. The diagnosis is usually established by specific serology markers and villous atrophy in duodenal biopsy. The causal and, in most cases, effective treatment modality is a strict and life ‑⁠ long gluten‑free diet that leads to regeneration of the intestinal mucosa and reduces the risk of serious complications.

Keywords:
coeliac disease –⁠ gluten –⁠ malabsorption –⁠ gluten‑free diet

Sources

1. Farrell RJ, Kelly CP. Celiac Disease and Refractory Celiac Disease. In: Feldman M, Friedman LS, Brandt LJ (eds). Slesinger and Fordtrans’s Gastrointestinal and Liver Disease. Philadelphia: Saunders 2010 : 1797 –⁠ 1820.

2. Rostom A, Murray JA, Kognoff MF. American Gastroenterological Association Instituce Technical Review on the Diagnosis and Management of Celiac Disease. Gastroenterology 2006; 131 : 1981 –⁠ 2002.

3. Romanos J, van Diemen CC, Nolte IM et al. Analysis of HLA and non‑HLA alleles can identify individuals at high risk for celiac disease. Gastroenterology 2009; 137 : 834 –⁠ 840. doi: 10.1053/ j.gastro.2009.05.040.

4. Wolters VM, Wijmenga C. Genetic background of celiac disease and its clinical implications. Am J Gastroenterol 2008; 103 : 190 –⁠ 195. doi: 10.1111/ j.1572 ‑⁠ 0241.2007.01471.x.

5. Walker ‑⁠ Smith JA, Guandalini S, Schmitz J et al. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Revised criteria for diagnosis of celiac disease. Arch Dis Child 1990; 65 : 909 –⁠ 911.

6. Sanders DS, Carter MJ, Hurlstone DP et al. Association of adult coeliac disease with irritable bowel syndrome: a case ‑⁠ control study in patiens fulfilling Rome II criteria referred to secondary care. Lancet 2001; 358 : 1504 –⁠ 1508.

7. Bardella MT, Vecchi M, Conte D et al. Chronic unexplained hypertransaminasemia mey be caused by occult celiac disease. Hepatology 1999; 29 : 654 –⁠ 657.

8. Carroccio A, Iannitto E, Cavataio F et al. Sideropenic anemia and celiac disease: one study, two points of view. Dig Dis Sci 1998; 43 : 673 –⁠ 678.

9. Fojtík P, Novosad P, Urban O et al. Screening celiakie u pacientů s osteoporózou a osteopenií. Vnitr lek 2011; 57 : 1000 –⁠ 1005.

10. Schuppan D, Hahn EG. Celiac disease and its link to type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2001; 14 (Suppl 1): 597 –⁠ 605.

11. Badenhoop K, Dieterich W, Segni M et al. HLA‑DQ2 and/ or HLA‑DQ8 is associated with celiac disease ‑⁠ specific autoantibodies to tissue transglutaminase in families with thyroid autoimmunity. Am J Gastroenterol 2001; 96 : 1648 –⁠ 1649.

12. Bureš J, Rejchrt S, Kopáčová M et al. Endoscopic features of coeliac disease. Folia Gastroenterol Hepatol 2005; 3 : 32 –⁠ 41.

13. Rubio ‑⁠ Tapia A, Hill ID, Kelly CP et al. ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease. Am J Gastroenterol 2013; 108 : 656 –⁠ 676. doi: 10.1038/ ajg.2013.79.

14. Smělá M, Bartušek D, Válek V et al. Využití ultrazvuku u pacientů s celiakií. Ces Radiol 2013; 67 : 46 –⁠ 51.

15. Mansueto P, Seidita A, D’Alcamo A et al. Non ‑⁠ celiac gluten sensitivity: literature review. J Am Coll Nutr 2014; 33 : 39 –⁠ 54. doi: 10.1080/ 07315724.2014.869996.

16. Vazquez ‑⁠ Roque MI, Camilleri M, Smyrk T et al. A controlled trial of gluten‑free diet in patients with irritable bowel syndrome ‑⁠ diarrhea: effects on bowel frequency and intestinal function. Gastroenterology 2013; 144 : 903 –⁠ 911. doi: 10.1053/ j.gastro.2013.01.049.

17. Palosuo K. Update on wheat hypersensitivity. Curr Opin Allergy Clin Immunol 2003; 3 : 205 –⁠ 209.

18. Gentile NM, Murray JA, Pardi DS. Autoimmune enteropathy: a review and update of clinical management. Curr Gastroenterol Rep 2012; 14 : 380 –⁠ 385. doi: 10.1007/ s11894 ‑⁠ 012 ‑⁠ 0276 ‑⁠ 2.