Authors: S. Kleinschmidt Authors‘ workplace: Klinik für Anaesthesiologie und Intensivmedizin der Universitätskliniken des Saarlandes, Homburg/Saar Published in: Anest. intenziv. Med., , 1999, č. 6, s. 268-272 Category:
An adequate balance of homeostasis, represented by various pro - and anti-inflammatory cytokines, is important for the maintenance of health.Deviation of the normal balance of pro - and anti-inflammatory cytokines will lead to severe restrictions of immune response. Cardiopulmonary bypass(CPB) is regarded as a reproducible model of inflammatory response and constitutes a major challenge to the patient’s ability to maintain this balance.Recent research has focused on the pro - and inflammatory cytokine balance, immune-modulating therapies and techniques to characterize the patient’sindividual immune status. The importance of cytokine balance and the various states of inflammatory response are briefly described and discussed.
Key words: cardiopulmonary bypass – cytokines – modulation of immune status
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