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Use of rotational thromboelastometry in perioperative medicine and its comparison with standard coagulation testing


Authors: J. Jonáš;  M. Durila;  M. Blahýnková;  T. Vymazal
Authors‘ workplace: Fakultní nemocnice v Motole, Praha ;  Klinika anesteziologie, resuscitace a intenzivní medicíny, 2. lékařská fakulta Univerzity Karlovy
Published in: Anest. intenziv. Med., 31, 2020, č. 5, s. 238-245
Category: Review Articles

Overview

Evaluation of the hemocoagulation status is one of the basic examinations in intensive and perioperative care. However, commonly used standard coagulation tests, such as prothrombin time, and activated partial thromboplastin time, do not provide comprehensive information on the hemocoagulation status. On the other hand, rotational thromboelastometry, as a dynamic viscoelastometric method, can examine all phases of secondary hemostasis. Its results thus better correspond to the in vivo situation. In addition, the results of rotational thromboelastometry are available earlier, and the implementation of this method into the perioperative bleeding management algorithm is associated with a reduction in blood loss, consumption of transfusion products and shorter length of stay in hospital. The aim of the following text is to bring the reader an overview of the possibility of using rotational thromboelastometry in pediatric and adult perioperative medicine, including the results of our own studies.

Keywords:

hemocoagulation – perioperative bleeding – rotational thromboelastometry – transfusion therapy


Sources

1. Pandey S, Vyas GN. Adverse effects of plasma transfusion. Transfusion. 2012; 52: 65–79.

2. Watson GA, Sperry JL, Rosengart MR, Minei JP, Harbrecht GB, Moore EE, et al. Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma. 2009; 67(2): 221–227.

3. Nienaber U, Innerhofer P, Westermann I, Schöchl H, Attal R, Breitkopf, et al. The impact of fresh frozen plasma vs coagulation factor concentrates on morbidity and mortality in trauma-associated haemorrhage and massive transfusion. Injury. 2011; 42: 697–701.

4. Seicean A, Alan N, Seicean S, Neuhauser D, Weil RJ. The effect of blood transfusion on short-term, perioperative outcomes in elective spine surgery. J Clin Neurosci. 2014; 21: 1579–1585.

5. Youssef LA, Spitalnik SL. Transfusion-related immunomodulation: A reappraisal. Curr Opin Hematol. 2017; 24(6): 551–557.

6. Hoffman M, Monroe DM 3rd. A cell-based model of haemostasis. Thromb Haemost. 2019; 85(6): 958–965.

7. Calatzis A, Görlinger K, Spannagl M, Vorweg M. ROTEM® Analysis Targeted Treatment of Acute Haemostatis Disorders. 2016. www.rotem.de.

8. Spahn D, Bouillon B, Cerny V, Duranteau J, Filipescu D, Hunt BJ, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Crit Care. 2019; 23: 98.

9. Kozek-Langenecker SA, Ahmed AB, Asfhari A, Albaladejo P, Aldecoa C, Barauskas G, et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016. Eur J Anaesthesiol. 2017; 34(6): 332–395.

10. Blatný J, Bláha J, Cvachovec K, Černý V, Firment J, Kubisz P, et al. Česko-slovenský mezioborový doporučený postup: Diagnostika a léčba život ohrožujícího krvácení u dospělých pacientů v intenzivní a perioperační péči. Anest Intenziv Med. 2017; 28(4): 263–269.

11. Zaoral T, Blatný J, Vobruba V, Nosáľ S, Raffaj D, Cvachovec K, et al. Česko-slovenský mezioborový doporučený postup: Diagnostika a léčba život ohrožujícího krvácení (ŽOK) u dětských pacientů v intenzivní a perioperační péči. Čes-slov Pediat. 2018; 73(1): 57–61.

12. Görlinger K, Pérez-Ferrer A, Dirkmann D, Saner F, Maegele M, Calatayud AAP, et al. The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management. Korean J Anaesthesiol. 2019; 72(4): 297–322.

13. Kuiper GJAJM, van Egmond LT, Henskens YMC, Roekaerts PM, Maessen JG, Cate HT, et al. Shifts of Transfusion Demand in Cardiac Surgery After Implementation of Rotational Thromboelastometry-Guided Transfusion Protocols: Analysis of the HEROES-CS (HEmostasis Registry of patiEntS in Cardiac Surgery) Observational, Prospective Open Cohort Database. J Cardiothorac Vasc Anesth. 2019; 33(2): 307–317.

14. Haas T, Goobie S, Spielmann N, Weiss M, Schmugge M. Improvements in patient blood management for pediatric craniosynostosis surgery using a ROTEM®-assisted strategy – feasibility and costs. Paediatr Anaesth. 2014; 24(7): 774–780.

15. Nakayama Y, Nakajima Y, Tanaka KA, Sessler DI, Maeda S, Iida J, et al. Thromboelastometry- -guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery. Br J Anaesth. 2015; 114(1): 91–102.

16. Vymazal T, Astraverkhava M, Durila M. Rotational thromboelastometry helps to reduce blood product consumption in critically ill patients during small surgical procedures at the intensive care unit – a restrospective clinical analysis and literature search. Transfus Med Hehmother. 2018; 45(6): 385–387.

17. Lukáš P, Durila M, Jonáš J, Vymazal T. Evaluation of thromboelastometry in sepsis in correlation with bleeding during invasive procedures. Clin Appl Thromb Hemost. 2018, Sep; 24(6): 993–997.

18. Durila M, Jonáš J, Durilová M, Rygl M, Skřivan J, Vymazal T. Thromboelastometry as an alternative method for coagulation assessment in pediatric patients undergoing invasive procedures: A pilot study. Eur J Pediatr Surg. 2018; 29(3): 298–301.

19. Bonnet A, Gilquin N, Steer N, Gazon M, Quattrone D, Pradat P, et al. The use of a thromboelastometry-based algorithm reduces the need for blood product transfusion during orthotopic liver transplantation: A randomised controlled study. Eur J Anaesthesiol. 2019; 36(11): 825–833.

20. Li C, Zhao Q, Yang K, Jiang L, Yu J. Thromboelastography or rotational thromboelastometry for bleeding management in adults undergoing cardiac surgery: a systematic review with meta-analysis and trial sequential analysis. J Thorac, DiS. 2019; 11(4): 1170–1181.

21. Buell TJ, Taylor DG, Chen CJ, Dunn LK, Mullin JP, Mazur MD,  et  al. Rotational thromboelastometry-guided transfusion during lumbar pedicle subtraction osteotomy for adult spinal deformity: preliminary findings from a matched cohort study. Neurosurg Focus. 2019; 46(4): E17.

22. Naik BI, Pajewski TN, Bogdonoff DI, Zuo Z, Clark P, Terkawi AS, et al. Rotational thromboelastometry-guided blood product management in major spine surgery. J Neurosurg Spine. 2015; 23: 239–249.

23. Jonáš J, Durila M, Malošek M, Marešová D, Štulík J, Barna M, et al. Usefulness of perioperative rotational thrombelastometry during scoliosis surgery in children. J Neurosurg Spine. 2020; 24: 1–6.

24. Bosch P, Kenkre TS, Londino JA, Cassara A, Yang C, Waters JH. Coagulation profile of patients with adolescent idiopathic scoliosis undergoing posterior spinal fusion. J Bone Joint Surg Am. 2016; 98: e88.

25. Haas T, Spielmann N, Mauch J, Madjdpour C, Speer O, Schmugge M, et al. Comparison of thromboelastometry (ROTEM) with standard plasmatic coagulation testing in paediatric surgery. Br J Anaesth. 2012, Jan; 108(1): 36–41.

26. Oswald E, Stalzer B, Heitz E, Weiss M, Schmugge M, Strasak A, et al. Thromboelastometry (ROTEM) in children: age-related reference ranges and correlations with standard coagulation tests. Br J Anaesth. 2010; 105: 827–835.

27. Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirbadi BS, et al. Thromboelastography as a Better Indicator of Hypercoagulable State After Injury Than Prothrombin Time or Activated Partial Thromboplastin Time. J Trauma. 2009, Aug; 67(2): 266–275.

28. Hincker A, Feit J, Sladen RN, Wagener G. Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery. Crit Care. 2014; 18(5): 549.

29. Blahýnková M. Analýza nákladové efektivity vybraných metod hodnocení hemostázy. Diplomová práce. 2018. FBMI ČVUT. Vedoucí práce Selčan M.

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Anaesthesiology, Resuscitation and Inten Intensive Care Medicine

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Anaesthesiology and Intensive Care Medicine

Issue 5

2020 Issue 5

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