#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Metamizole – 100 years since discovery


Authors: J. Málek
Authors‘ workplace: Komise pro historii ČSARIM JEP ;  Klinika anesteziologie a resuscitace 3. lékařské fakulty UK a FN Královské Vinohrady Praha
Published in: Anest. intenziv. Med., 31, 2020, č. 3, s. 83-85
Category: Review Articles

Overview

Curious history of a non-opioid analgesic metamizole is presented. Metamizole is a direct derivate of the first chemical analgesic drugs synthetized in the 19th century. During 100 years of its existence, metamizole was banned in many countries, while in others, including the Czech Republic gains popularity and is frequently used as a compound of multimodal treatment of postoperative pain.

Keywords:

history – non -opioid analgesics – metamizole – pharmacodynamics – side effects


Sources

1. Brune K. The early history of non‑opioid analgesics. Acute Pain 1997; 1(1): 33–40.

2. Brune K, Hinz B. The discovery and development of antiinflammatory drugs. Arthritis and Rheumatology 2004; 50(8): 2391–2399.

3. Rinsema TJ. One hundred years of aspirin. Med Hist 1999; 43: 502–507

4. Ellis F. Paracetamol – a curriculum resource. Royal Society of Chemistry, London 2002 [on-line] [cit 2020-05-22]. Dostupné z: https://books.google.cz/books?id=30xrr1Yz‑ sFQC & pg=PP5 & lpg=PP5 & dq=paracetamol,+discovery & source=bl & ots=FQiAyD‑ Gjxl & sig=ACfU3U2MqS76xjFpUtUnhettKsDahlgWYA & hl=cs & sa=X & ved=2ahUKEwiU‑amQmcfpAhVkBGMBHWY3BTIQ6AEwB3oECAoQAQ#v=onepage & q=paraceta‑ mol%2C%20discovery & f=false.

5. Jasiecka A, Maślanka T, Jaroszewski JJ. Pharmacological characteristics of metamizole. Pol J Vet Sci 2014; 17: 207–214.

6. Hearn L, Derry S, Moore RA. Single dose dipyrone (metamizole) for acute postoperative pain in adults. Cochrane Database Syst Rev. 2016; 4(4): CD011421. doi:10.1002/14651858. CD011421.pub2

7. Lal A, Pandey K, Chandra P, Pande SB. Dipyrone for treatment of post‑operative pain. Anaesthesia. 1973; 28(1): 43–47.

8. Nikolova I, Tencheva J, Voinikov J, et al. Metamizole: A Review Profile of a Well‑Known „Forgotten“ Drug. Part I: Pharmaceutical and Nonclinical Profile. Biotechnology & Biotechnological Equipment. 2012; 26(6): 3329–3337.

9. Miljković MN, Rančić NK, Simić RM, Stamenković DM, Dragojević‑Simić VM. Metamizole: Current Status of the Safety and Efficacy. Hospital Pharmacology. 2018; 5(3): 694–704. doi:10.5937/hpimj1803694M

10. Nikolova I, Petkova V, Tencheva J, Benbasat N, Voinikov J, Danchev N. Metamizole: A Review Profile of a Well‑Known „Forgotten“ Drug. Part II: Clinical Profile, Biotechnology & Biotechnological Equipment 2013, 27(2): 3605–3619. doi: 10.5504/BBEQ.2012.0135

11. Konijnenbelt‑Peters J, van der Heijden C, Ekhart C, Bos J, Bruhn J, Kramers C. Metamizole (Dipyrone) as an Alternative Agent in Postoperative Analgesia in Patients With Contraindications for Nonsteroidal Anti‑Inflammatory Drugs. Pain Pract 2017 Mar; 17(3): 402–408. doi: 10.1111/papr.12467. Epub 2016 Jun 27.

12. Huber M, Andersohn F, Sarganas G, Bronder E, Klimpel A, Thomae M, et al. Metamizole‑induced agranulocytosis revisited: results from the prospective Berlin Case‑Control Surveillance Study. Eur J Clin Pharmacol. 2015; 71(2): 219–227.

13. Blaser LS, Tramonti A, Egger P, Haschke M, Krähenbühl S, Rätz Bravo AE. Hematologi‑ cal safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports. Eur J Clin Pharmacol. 2015; 71(2): 209–217.

14. Kötter T, da Costa BR, Fässler M, Blozik E, Linde K, Jüni P, et al. Metamizole‑Associated Adverse Events:A Systematic Review and Meta‑Analysis. PLOS ONE April 13, 2015 [on-line] [cit. 2020-05-24]. doi: 10.1371/journal.pone.0122918. Dostupné z https://www.ncbi.nlm.nih. gov/pmc/articles/PMC4405027/pdf/pone.0122918.pdf

15. Shah RR. Metamizole (dipyrone) – induced agranulocytosis: Does the risk vary according to ethnicity? J Clin Pharm Ther. 2019; 44: 129–133.

16. Day A. Nolotil: Patients’ Families Demand Ban Of Controversial Painkiller. HuffPost. News 16. 6. 2019. [on-line] [cit. 2020-05-25]. Dostupné z: https://www.huffingtonpost. co.uk/entry/this‑controversial‑painkiller‑could‑be‑linked‑to‑the‑deaths‑of‑brits‑in‑spain‑now‑families‑want‑it‑banned_uk_5cdd5660e4b09648227bd9f6?guccounter=1 & guce_ referrer=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8 & guce_referrer_sig=AQAAAA0kV9z3v‑ TEkhbffMTmn1AGE9qzSAzJZ9vMY0KPJZLnXIB45z61GFZmSVsuoILXNetHlFYPkkEV6-nj1Le‑ hEhhaJ1b2WxeByi5LyMAO_6ajv_Q2M5K_OYPcN0hELXatXGEf190pTJ7M2DJ3M5IisfxlpD‑ NW_ezCIG8uNanjYk5UL

17. European Medicines Agency. Assessment report, Referral under Article 31 of Directive 2001/83/EC metamizole‑containing medicinal products. [on-line] [cit. 2020-05-24]. Dostupné z: https://www.ema.europa.eu/en/documents/referral/metamizole‑article-31-referral‑chmp‑assessment‑report_en.pdf

18. Novotná B. Aspirin‑senzitivní asthma bronchiale. [on-line] [cit. 2020-06-01]. Dostupné z: https://www.cipa.cz/astma‑pri‑nesnasenlivosti‑aspirinu

19. Blanca‑López N, Pérez‑Sánchez N, Agúndez JA, García‑Martin E, Torres MJ, Cornejo‑García JA, et al. Allergic reactions to metamizole: immediate and delayed responses. Int Arch Allergy Immunol 2016; 169: 223–230. doi: 10.1159/000444798

20. Machado‑Albaa JE, Urbano‑Garzón SF, Gallo‑Gómez YN, Zuluaica S, Henao Y, Parrado‑Fajardo IY. Severe anaphylaxis reaction from dipyrone without a history of hypersensitivity. Case report. Colombian Journal of Anesthesiology 2017; 45(Supplement 1): 8–11. 21. SÚKL. Metamizol‑SPC. [on-line] [cit. 2020-06-01]. Dostupné z: http://www. sukl.cz/modules/medication/search.php?data%5Bsearch_for%5D=&data%5B‑ code%5D=&data%5Batc_group%5D=&data%5Bmaterial%5D=metamizol & da‑ ta%5Bpath%5D=&data%5Breg%5D=&data%5Bradio%5D=none & data%5Brc%5D =&data%5Bchbox%5D%5B0%5D=braill‑yes & data%5Bchbox%5D%5B1%5D=braill‑ ‑no & data%5Bchbox%5D%5B2%5D=braill‑def & data%5Bwith_adv%5D=0 & data%5B‑ listing%5D=20 & search=Vyhledat & page=2 22. SÚKL. Dodávky léčiv - se zaměřením na léčivé látky. [on-line] [cit. 2020-05-20]. Dostupné z: http://www.sukl.cz/rok-2020

Labels
Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#