Authors: E. Kurča 1; B. Sániová 2; M. Drobný 1; P. Kučera 3 Authors‘ workplace: Neurologická klinika JLF UK a FN Martin, prednosta prof. MUDr. Michal Drobný, DrSc. 2 ARK JLF UK a FN Martin, prednosta MUDr. Beata Sániová, CSc. 3 1. neurologická klinika LF UK a FN Bratislava, prednosta prof. MUDr. Pavol Traubner, CSc. 1 Published in: Anest. intenziv. Med., , 1998, č. 6, s. 221-225 Category:
Malignant hyperthermia (MH) is a hereditar disorder of skeletal muscle characterised by a paroxysmal hypermetabolic state of muscle fibers. MH is triggered by some drugs usually during general anesthesia. MH may lead to death if no accurate therapy is applied immediately. An overview of MH epidemiology, pathogenesis, clinics, therapy and genetics is presented with attention to counselling and situation in Slovakia.
Key words: malignant hyperthermia – masseter rigidity – calcium channels – genetics
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