The results of therapy with dupilumab in children and adolescents with severe forms of atopic dermatitis (AD) are very good even after a short period, not only from a health perspective but also in terms of the social aspect of the disease and the quality of life of patients. This is illustrated by the following two case studies – an 8-year-old girl and a 17-year-old boy – from the Center for Biological Treatment at the Dermatovenerology Clinic of the 2nd Faculty of Medicine, Charles University, and Bulovka University Hospital.