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News Current NCCN Recommendations for Classification and Risk Symptoms in SLL/CLL

The new recommendations from the National Comprehensive Cancer Network (NCCN) regarding chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) from August 2022 also include a brief summary of the most common symptoms and methods for classifying the disease based on its extent at diagnosis or in case of progression.

Source: Chronic Lymphocytic Leukemia 12. 1. 2023

News Current Recommendations by the ELN Expert Panel on AML Diagnosis Management

The 2022 recommendations from European LeukemiaNet (ELN) add new information to the previous recommendations from 2010 and 2017. They concern the diagnosis and treatment of acute myeloid leukemia (AML) in adults from the perspective of pathogenesis, disease classification adjustment, possibilities of genomic diagnosis, and the inclusion of minimal residual disease (MRD) assessment.

Source: Acute Myeloid Leukemia 9. 5. 2023

News The Benefit of Liposomal Irinotecan in the Treatment of Pancreatic Cancer in a Young Patient –⁠ A Case Study

Pancreatic tumors continue to be a challenge in modern oncology. Due to the asymptomatic nature of early stages, most cases are diagnosed in advanced stages. The five-year survival rate of patients does not even reach 10%, and up to half of patients with metastatic pancreatic cancer never make it to the second line of systemic therapy due to the rapid deterioration of their overall clinical condition. In a case study from her own practice, Dr. Marie Beneš Kočová from the Oncology Department of České Budějovice Hospital shared her experience with the treatment of a relatively early-detected disease in a young patient.

Source: Treatment of Gastrointestinal Carcinomas 9. 9. 2024

News Viral or Bacterial Etiology? Old Question, New Methods...

The gold standard in the differential diagnosis of viral and bacterial respiratory infections is primarily C-reactive protein (CRP), followed by procalcitonin and interleukins. What are the pitfalls of their use, and what new methods of distinguishing the etiology of infectious diseases are currently being developed?

Source: Cough Therapy 13. 12. 2022

News Impact of Azacitidine Maintenance Therapy on Survival of Patients with AML in Remission Depending on Initial Chemotherapy

The QUAZAR AML-001 study showed that oral azacitidine maintenance therapy significantly prolongs relapse-free survival (RFS) and overall survival (OS) in patients with acute myeloid leukemia (AML) in first remission after intensive chemotherapy (including induction ± consolidation therapy), who are not candidates for hematopoietic stem cell transplantation (HSCT), compared to placebo. In October 2023, results of a subgroup analysis of patients stratified according to the use/non-use of consolidation chemotherapy and the number of consolidation chemotherapy cycles administered before entering the study were published.

Source: Acute Myeloid Leukemia 24. 1. 2024

News Mavacamten in the Treatment of HCM in Patients Referred for Septal Reduction

Extended 56-week follow-up of patients with hypertrophic cardiomyopathy (HCM) resistant to current pharmacotherapy in the VALOR-HCM study confirmed the lasting benefit of mavacamten –⁠ the first representative of a new class of selective reversible cardiac myosin inhibitors –⁠ as a new pharmacological treatment option reducing the need for invasive procedures.

Source: Hypertrophic Cardiomyopathy (HCM) 19. 2. 2024

News Current Reimbursement Conditions for the Dual Inhibitor IL-4/IL-13 Dupilumab

The biologic dupilumab is approved for the treatment of several diseases with type 2 inflammation. What is the current reimbursement situation in key indications? We summarize in the following brief overview.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 4. 3. 2024

News Pathogenetic Mechanisms Underlying the Development and Progression of Interstitial Lung Diseases

Interstitial lung processes (ILP) represent an umbrella term for a wide range of nosological units that differ from each other in clinical course, prognosis, and pathogenesis. Most ILPs are characterized by inflammation or fibrosis of the interstitial space, leading to impaired gas exchange at the alveolocapillary membrane.

Source: Progressive Interstitial Pulmonary Processes 6. 12. 2022

News Natural Doesn’t Always Mean Better –⁠ How to Deal with the Appeal to Nature in the Doctor’s Office

"Herbs rather than chemicals." Doctors are hearing similar statements more and more often. This attitude reflects the so-called appeal to nature –⁠ a logical fallacy based on the assumption that natural means better and safer. In academic literature, this type of thinking is more broadly referred to as the naturalistic fallacy. Such reasoning significantly influences not only patients’ decisions but often also those of healthcare professionals themselves.

Source: 11. 8. 2025

News Pharmacotherapy of Glaucoma in a Nutshell According to the Latest Recommendations of the European Glaucoma Society

The European Glaucoma Society published its latest, 5th version of recommendations for the treatment of glaucoma in 2021. The following text, based on these recommendations, focuses in a nutshell on the basic principles of pharmacotherapy for this disease according to current knowledge.

Source: Treatment of Glaucoma 18. 5. 2023

News Allergic Rhinitis in the General Practitioner’s Office: How to Proceed in Primary Care?

Up to 60% of the population has a genetic predisposition to allergic disease. Diagnosis and therapy of allergic conditions are therefore very common topics in primary care. How should we proceed correctly in the diagnostic process when suspecting allergic rhinitis? When to refer to a specialist and what are the treatment options?

Source: Life Without Allergic Rhinitis 7. 6. 2022

News What a Decade of Experience with Tapentadol Hydrochloride in Pain Treatment Has Shown

In an interview with Dr. Marek Hakl, Ph.D., from the Brno Pain Treatment Center, we focus on the role of tapentadol hydrochloride in the treatment of chronic pain. We discuss, among other things, its suitability for specific patients and the latest findings that confirm its excellent efficacy and fewer side effects compared to other opioids.

Source: Updates in Pain Treatment 12. 10. 2023

News CYP Enzyme? Cytochrome P450 2D6 and Drug Metabolism

The CYP2D6 isoenzyme of cytochrome P450 participates in the metabolism of approximately 20% of commonly used drugs. Genetic variants of this enzyme are very common, leading to significant inter-individual variability in drug metabolism rates. Let’s take a closer look at one of the reasons why the same drug may work very well in one patient, not at all in another, and may cause serious side effects in a third.

Source: Genetics 5. 5. 2023

News A Look at Tongue and Its Care from the Perspective of Western and Traditional Chinese Medicine

The tongue is a valuable diagnostic tool used in both Traditional Chinese Medicine (TCM) and Western medicine. While the approaches to tongue care between these two medical systems differ significantly, both recognize the tongue's ability to reflect an individual's overall health. Although these approaches may seem contradictory, with proper application, they can complement each other.

Source: Dental Care 6. 9. 2023

News Current NCCN Recommendations for CLL/SLL Diagnosis –⁠ Version 1.2023

In August 2022, the latest guidelines from the National Comprehensive Cancer Network (NCCN) concerning chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) were published. Here we present the essential extract from these recommendations for diagnosing both diseases.

Source: Chronic Lymphocytic Leukemia 23. 11. 2022