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News The Benefit of Dabigatran Over Warfarin Is Greater in Patients with Atrial Fibrillation and Diabetes Than in Nondiabetics

As early as 2015, an analysis of the results of the RE-LY study in patients with atrial fibrillation showed that the reduction in absolute risk of embolic events with dabigatran compared to warfarin is greater in patients with diabetes than in those without diabetes.

Source: Anticoagulant Treatment 24. 4. 2020

News Safety and efficacy of dabigatran and other NOACs compared with warfarin in patients with atrial fibrillation –⁠ results of a large long-term prospective study

Anticoagulant therapy is key in the prevention of strokes in patients with atrial fibrillation. Until the introduction of new oral anticoagulants (NOACs), warfarin was the first-choice drug for these patients, but unlike NOACs, it requires careful dose titration and effect monitoring. The safety and benefits of using various anticoagulants were examined in the study below.

Source: Anticoagulant Treatment 25. 5. 2020

News Comparison of the Effectiveness of Different Types of Toothbrushes in Orthodontic Patients

The aim of the study cited below was to evaluate the efficiency of a manual orthodontic brush, an electric toothbrush with an oscillating head, and a sonic toothbrush in controlling plaque, gingivitis, and interproximal bleeding in patients undergoing orthodontic treatment with fixed appliances and to compare their relative effectiveness.

Source: Dental Care 10. 5. 2023

Články časopisu Inherited Thrombophilic Tendencies and Oral Contraceptive Pills

Author of the article: I. Hadačová Source: Česko-slovenská pediatrie | 6/2010 19. 8. 2010

News Subcutaneous Immunoglobulin Therapy in Patients with Secondary Immunodeficiency –⁠ Real-World Data

Even in patients with secondary immunodeficiency (SID), immunoglobulin substitution can be indicated. Intravenous (IVIG) therapy is considered effective based on studies, but subcutaneous (SCIG) therapy is only based on experiences with patients having primary immunodeficiency (PID). The Italian study presented below, therefore, investigated the efficacy and safety of SCIG in patients with SID.

Source: Primary and Secondary Immunodeficiencies 2. 10. 2023

News Could candesartan counteract adverse intestinal changes induced by hypertension?

An experimental study published last year was the first to show that administration of candesartan may increase the tightness of epithelial junctions in the intestinal wall and positively affect the composition of the microflora. It expands the knowledge of recently described pathophysiological changes in the gut associated with hypertension.

Source: Sartans in the Treatment of Hypertension 6. 3. 2020

News Safety and Efficacy of Combination Therapy for Allergic Rhinitis Compared to Monotherapies and Placebo

Combination therapy of antihistamine and corticosteroid is a promising alternative for patients suffering from seasonal allergic rhinitis. A phase II clinical study aimed to determine the effective dosage, efficiency, and safety of combination therapy compared to monotherapies and placebo.

Source: Life Without Allergic Rhinitis 7. 6. 2022

News Will 3D Printable Tissue Adhesives Replace Stitches and Clips?

3D printing technology is slowly making its way into more and more areas of healthcare. In February 2024, a scientific team from the Massachusetts Institute of Technology (MIT) published a study in the journal Nature Communications focusing on the possibilities of 3D printing tissue adhesives and personalized patches with adjustable internal structures. These could therefore become a suitable alternative to the traditional surgical sutures and clips used for joining tissues.

Source: 8. 5. 2024

News Overall Survival in Patients with Metastatic CRC During 1st-Line Anti-EGFR Treatment Depending on the Presence or Absence of Hypomagnesemia

Hypomagnesemia is one of the side effects of monoclonal antibody therapy against the epidermal growth factor receptor (EGFR). The study presented below examined overall survival in patients with metastatic primarily unresectable colorectal cancer (CRC) treated with anti-EGFR therapy depending on the presence or absence of hypomagnesemia.

Source: Colorectal Cancer 3. 10. 2022

News Comparison of BEAM and TEAM Conditioning Regimens Before Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Lymphomas

At the beginning of this year, one of the few studies comparing the most commonly used conditioning regimen before autologous hematopoietic stem cell transplantation (ASCT) in patients with lymphomas (BEAM) with a regimen containing thiotepa instead of carmustine (TEAM) was published.

Source: Oncological Treatment 13. 6. 2023

Články časopisu Significance of vitamin D for human health

Author of the article: S. Skácelová Source: Česká revmatologie | 1/2010 14. 4. 2010

News Self-administration of alpha-1-antitrypsin can significantly improve patients' quality of life

Treatment of alpha-1 antitrypsin deficiency (AATD) requires lifetime administration of weekly intravenous infusions of this substance, mostly in medical facilities. The possibility of AAT application at home is being discussed. This topic was also addressed at a symposium held during the European Respiratory Society (ERS) congress, which took place in November 2019 in Madrid.

Source: Deficiency of Alpha-1-Antitrypsin 20. 8. 2020

News Efficacy of Bisoprolol in Patients After Acute MI with LV Systolic Dysfunction

What impact does one year of bisoprolol use have in real-world practice on heart rate, left ventricular ejection fraction (LVEF), glycated hemoglobin (HbA1c) levels, or lipid profile in patients after acute myocardial infarction (AMI) with left ventricular systolic dysfunction (LVSD)? This was investigated by the authors of a study whose results were published last year.

Source: Cardiovascular Continuum 27. 3. 2023

News Do ACE Inhibitors Have a Protective Effect in People with COVID-19?

Although the COVID-19 pandemic has not lasted even a year, a number of studies have already been processed, examining the influence of various factors on the morbidity and mortality of patients. The presented meta-analysis investigated the influence of ACE inhibitors on the mortality of patients with this disease.

Source: ACE inhibitory 25. 2. 2021

News Combination of SGLT2 inhibitors with metformin in terms of mechanism of action

In the treatment of type 2 diabetes (T2D), metformin is recommended as the first-line drug alongside lifestyle modification. However, with disease progression, monotherapy is often insufficient. SGLT2 inhibitors (SGLT2i) are recommended in combination with metformin in light of recent findings, as their mechanism of action is independent of insulin effect. They have shown a reduction in cardiovascular (CV) risk in diabetics with CV disease.

Source: Diabetes 18. 3. 2020