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News Hypertrophic Cardiomyopathy: When Bigger Does Not Mean Better

Hypertrophic cardiomyopathy (HCM) is a hereditary disease that, in some patients, proceeds asymptomatically, while others struggle with arrhythmias or heart failure, and in some individuals, the first manifestation of the disease can be sudden cardiac death. More about the etiology and diagnosis of HCM is discussed in the following overview.

Source: Hypertrophic Cardiomyopathy (HCM) 7. 9. 2023

News Transthyretin –⁠ More Than a Thyroxine Transporter

Transthyretin (TTR) is an extracellular protein whose main role is to transport thyroxine and retinol in the body and brain. TTR tends to form amyloid deposits, which can lead to systemic disease known as TTR amyloidosis. Recently, it has been shown that this protein has a much wider spectrum of activities in the organism than previously thought.

Source: Amyloidosis 6. 2. 2023

News Invitation to June: ESMO Gastrointestinal Cancers Congress 2024, Munich

Source: Treatment of Gastrointestinal Carcinomas 31. 5. 2024

News INFOGRAPHIC: Determining the Target Intraocular Pressure in Glaucoma Therapy

The goal of glaucoma treatment is to preserve the visual field and the quality of life of patients. Currently, the only approach to preserving the visual field of patients is to reduce intraocular pressure (IOP). Its target value should be determined for each patient with consideration of individual risk factors. The following comprehensive infographic shows which factors should be considered according to the current recommendations of the European Glaucoma Society (EGS).

Source: Treatment of Glaucoma 14. 7. 2023

News Gene Therapy for Hemophilia A: What is the Expression of Factor VIII Using the Adeno-Associated Viral Vector SPK-8011?

The goal of gene therapy for hemophilia A is to safely transfer stable and durable expression of coagulation factor VIII (FVIII), which predictably improves the bleeding phenotype at the lowest possible vector dose. Updated data from a study examining the use of the adeno-associated viral vector (AAV) SPK-8011 were presented during the virtual congress of the International Society on Thrombosis and Haemostasis (ISTH) 2021.

Source: Quality Life Even with Hemophilia 24. 11. 2021

News Clinical Profile and Outcomes of Patients with Cardiac Amyloidosis –⁠ Spanish Experience from Real Practice

Cardiac amyloidosis is caused by the deposition of amyloid fibrils in the myocardium and is among the diseases with significant diagnostic delay. Physicians from the University Hospital in Madrid shared their experiences with the diagnosis and treatment of these patients over the last decade in the cited work below.

Source: Amyloidosis 14. 6. 2023

News When You Say Amyloid…

The term 'amyloid' was first used by the German doctor Rudolf Virchow in the mid-19th century. He described it as a pathological substance which he originally thought was starch. Although it was quickly discovered that it was a substance of protein nature, the reference to starch (from the Greek amylon) remained in the name.

Source: Amyloidosis 12. 12. 2022

News Ozanimod Expands Treatment Options for Ulcerative Colitis in Adult Patients

As a review article published last year in the journal Drugs suggests, ozanimod is an effective and well-tolerated medication for adult patients with moderate to severe ulcerative colitis (UC), both in the initial phase of treatment and in the maintenance phase after achieving remission.

Source: Modulation of S1P in the Treatment of Autoimmune Diseases 9. 5. 2023

Články časopisu Non-Hodgkin lymphomas in the Czech Republic

Author of the article: M. Trněný Source: Transfuze a hematologie dnes | 1/2019 29. 3. 2019

News Benefit of Oral Semaglutide for Patients with Type 2 Diabetes in the General Practitioner's Office

Oral semaglutide is a modern antidiabetic suitable within primary care for people with type 2 diabetes, primarily due to its comprehensive action that includes not only reducing blood glucose and body weight but also a number of other favorable non-glycemic effects.

Source: Modern Treatment of Diabetes with GLP-1 Analogues 22. 5. 2024

Články časopisu "The dead shall be raised": Multidisciplinary analysis of human skeletons reveals complexity in 19th century immigrant socioeconomic history and identity in New Haven, Connecticut

Author of the article: Gary P. Aronsen, Lars Fehren-Schmitz, John Krigbaum, George D. Kamenov, Gerald J. Conlogue, Christina Warinner, Andrew T. Ozga, Krithivasan Sankaranarayanan, Anthony Griego, Daniel W. DeLuca, Howard T. Eckels, Romuald K. Byczkiewicz, Tania Grgurich, Natalie A. Pelletier, Sarah A. Brownlee, Ana Marichal, Kylie Williamson, Yukiko Tonoike, Nicholas F. Bellantoni Source: PLOS One | 9/2019 9. 9. 2019

Články časopisu Antidiabetic treatment in prevention of atherosclerosis: last decade

Author of the article: Emil Martinka Source: Forum Diabetologicum | Supplementum 1/2021 17. 9. 2021

Články časopisu Innovative Bariatric Procedures and Ethics in Bariatric Surgery: the IFSO Position Statement

Author of the article: Ashraf Haddad, Lilian Kow, Miguel F. Herrera, Ricardo V. Cohen, Jacques Himpens, Jan Willem Greve, Scott Shikora Source: Časopis lékařů českých | 7-8/2022 11. 2. 2023

Články časopisu XLIVrd Work Days of the Pharmacological Section of the Czech Nuclear Medicine Society(FaF UK, Hradec Králové, 31. 5. to 2. 6. 2023)

Source: Česká a slovenská farmacie | 5/2023 5. 1. 2024

Články časopisu Darier Disease: Current View. Part II.

Author of the article: M. Důra, J. Štork Source: Česko-slovenská dermatologie | 3/2020 9. 6. 2020