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News Current Data of Tofacitinib in the Treatment of IBD: What Improvements in Endoscopic and Histologic Outcomes Can Be Achieved?
The oral Janus kinase inhibitor (JAKi) tofacitinib is currently approved for the treatment of moderately to severely active ulcerative colitis (UC). Its efficacy and safety in this indication have previously been investigated in randomized placebo-controlled trials. However, the study discussed below examined the drug's impact on the endoscopic and histological progression of the disease and fecal calprotectin levels.
News Case Study of a Patient with NSCLC − with Voting
Presented by: MUDr. Leona Koubková,
Pneumology Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital in Prague
News Sport and Physical Activity Benefit Hemophiliacs
Sport and physical activity are beneficial for individuals with hemophilia. This statement was confirmed by a study conducted by German and British authors published in the journal Haemophilia.
News COVID-19 in Patients with Acquired Hemophilia A − Case Reports
At the XXVIII. Pařízek Days held in Ostrava, on the afternoon of March 17, 2022, Dr. Anna Maria Pejková from the 4th Internal Clinic of the University Hospital Hradec Králové presented 3 case reports of acquired hemophilia A.
News Fixed Combination of Tramadol/Paracetamol in the Treatment of Chronic Lower Back Pain and Its Effect on Apathy in Chronically Algic Patients
Long-term chronic pain is associated with apathy, loss of motivation, and depression in patients. However, these comorbidities of chronic pain and their interconnections are still insufficiently explored. The aim of the Japanese study was to evaluate the prevalence of apathy in patients with chronic low back pain (LBP) and the therapeutic efficacy of the fixed combination of tramadol/paracetamol in treating this pain and its effect on apathy in LBP patients.
News Romiplostim Before Splenectomy in a Patient with ITP - Case Report
In the following case report from authors at a university hospital in Barcelona, the successful use of romiplostim as a second-line treatment before planned splenectomy in a patient with immune thrombocytopenia (ITP), liver cirrhosis, and iatrogenic Cushing's syndrome is demonstrated.
News Incidence of Secondary Malignancies in CLL Patients on FCR Regimen in Central Europe
Chronic lymphocytic leukemia (CLL) represents the most common type of leukemia in Western countries with closely related incidence in Central European states. Since 2000, new therapeutic regimens have been explored and applied in an effort to improve patient prognosis, including the combination of fludarabine, cyclophosphamide, and rituximab (FCR). However, the development of new therapeutic regimens is also associated with concerns about the risk of secondary malignancies.
News Efficacy of Romiplostim in Children with Persistent or Chronic ITP
The effect of the thrombopoietin receptor agonist romiplostim in adult patients with immune thrombocytopenia (ITP) is well known. Equally important, however, are data on its treatment in children — presented by a study whose results were published in the journal Lancet.
News Self-administration of alpha-1-antitrypsin can significantly improve patients' quality of life
Treatment of alpha-1 antitrypsin deficiency (AATD) requires lifetime administration of weekly intravenous infusions of this substance, mostly in medical facilities. The possibility of AAT application at home is being discussed. This topic was also addressed at a symposium held during the European Respiratory Society (ERS) congress, which took place in November 2019 in Madrid.
News Clinical Characteristics of Trauma Patients Requiring Dosing Adjustments of Enoxaparin in TEN Prevention
Injuries and trauma surgical procedures represent a significant risk factor for the development of thromboembolic disease (TEN). Routine thromboprophylaxis is thus recommended for trauma patients, often in the form of low molecular weight heparins (LMWH), including enoxaparin. A recently published study evaluated factors associated with the need for higher dosing of enoxaparin to achieve effective prophylactic levels.
News Liposomal Pegylated Irinotecan in the Treatment of Pancreatic Tumors
Combined treatment with liposomal pegylated irinotecan, 5-fluorouracil (5-FU), and leucovorin (LV) significantly improves overall survival in patients with metastatic ductal carcinoma of the pancreas. Analysis of the NAPOLI clinical trial revealed prognostic markers for long-term survival in patients treated this way.
News ESC 2022: What Current Insights Say About the Role of Dabigatran in Stroke Prevention with Atrial Fibrillation and Comorbidities
The risk of atrial fibrillation (AF) increases with age as risk factors accumulate and comorbidities arise. What do current data from randomized clinical trials and registries show about stroke prevention (SP) in the context of concurrent AF and some other chronic diseases? This was the focus of one of the symposia at this year's European Society of Cardiology (ESC) Congress.
News Irritable Bowel Syndrome and Non-specific Inflammatory Bowel Diseases Are Not Evolutionarily Related Diseases
The authors of the presented work attempted to compare the geographical distribution of irritable bowel syndrome and non-specific inflammatory bowel diseases and other factors related to these two diseases to reveal their potential evolutionary connection.
News VIDEO: Antibiotic Treatment of Infections Caused by MDR Bacteria – Seminar Recording
Recording of a professional seminar on the topic of infections caused by MDR bacteria, which took place on November 2, 2021, at the Medical House in Prague.
News Safety and Efficacy of Combination Therapy for Allergic Rhinitis Compared to Monotherapies and Placebo
Combination therapy of antihistamine and corticosteroid is a promising alternative for patients suffering from seasonal allergic rhinitis. A phase II clinical study aimed to determine the effective dosage, efficiency, and safety of combination therapy compared to monotherapies and placebo.
News Is the efficacy of bisoprolol in secondary prevention of acute myocardial infarction in patients after percutaneous coronary intervention comparable to carvedilol?
Beta-blockers (BB) are recommended for all patients after percutaneous coronary intervention (PCI) as part of secondary prevention of acute myocardial infarction (AMI). The study presented below compared the efficacy of carvedilol – a vasodilating beta-blocker, whose benefit in this indication was confirmed by a randomized clinical trial – with the effect of bisoprolol.
News Genetic Testing in Non-Small Cell Lung Cancer - Clinical Practice Experience
Targeted therapy has brought significant improvements to certain groups of patients with non-small cell lung cancer (NSCLC). Selecting patients who will benefit from targeted therapy can be performed using molecular profiling with next-generation sequencing (NGS) techniques. However, we still lack sufficient data on the feasibility and results of such profiling in real-world clinical practice, which was the focus of an analysis recently published in The Oncologist.
News Comparison of the effects of fibrinogen concentrates and fresh frozen plasma in patients with acute traumatic coagulopathy
A quasi-experimental study compared the effectiveness of fibrinogen concentrates and fresh frozen plasma in patients with severe blunt trauma requiring the administration of erythrocyte replacements.
News Nonacog Beta Pegol (N9-GP) in Bleeding Prophylaxis in Patients with Hemophilia B – Real World Data
The goal of hemophilia B treatment is currently the prevention of bleeding by administering a coagulation factor IX concentrate. The study presented below brings recent real-world data on treatment outcomes when switching to the latest preparation, nonacog beta pegol (N9-GP).
News Colours of Sepsis 2023: Antimicrobial Stewardship is a Necessity. The Spectrum of Effective Antimicrobial Modalities has Expanded to Include Another Combination
Inappropriate antibiotic (ATB) treatment is associated with high mortality, while unrestricted use of broad-spectrum antibiotics drives resistance development. Thus, the decision to deploy antibiotics becomes a choice between the current and future patient. Antimicrobial stewardship (AMS) is an essential strategy in daily operations. Extending the spectrum of antimicrobial agents is equally crucial in combatting resistant bacterial strains. A symposium on this theme was part of the expert program at this year's 'festival of intensive medicine' Colours of Sepsis, held in late January in Ostrava.
News Composition of the Intestinal Microbiota of Patients with IBS May Predetermine the Success of a Diet with Low Fermentable Carbohydrates
Some patients with irritable bowel syndrome may benefit from a diet low in fermentable carbohydrates, but the mechanism of this intervention is not yet satisfactorily explained. A study published in Gut focused on the relationship between the composition of the intestinal microbiota and clinical response to dietary intervention.
News Results of ATTUNE Total Knee Replacement Implantation – Data from the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man
The ATTUNE knee replacement system was fully introduced into clinical practice in 2013. Since then, tens of thousands of implants have been administered to patients worldwide. The mid-term results are very positive, as evidenced by data from the National Joint Registry for England, Wales, Northern Ireland, and the Isle of Man.
News International Recommendations for COVID-19 Vaccination in People with Bleeding Disorders
At the end of December 2020, international guidelines for COVID-19 vaccination in people with bleeding disorders were published on the World Federation of Hemophilia (WFH) website. We present a basic summary of 13 points of this consensus. The original English version is available via the web link cited at the end of the article.