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News Can Co-administration of Dabigatran with Antiretroviral Drugs Be Effective and Safe?

In 2019, the first results regarding the concurrent use of antiretroviral drugs and oral anticoagulants were published. This involved 14 patients with atrial fibrillation and HIV infection, in whom the concurrent administration of dabigatran with antiretroviral drugs was not associated with the occurrence of thromboembolic events or bleeding during follow-up lasting up to 40 months.

Source: Anticoagulant Treatment 6. 5. 2021

News Metamizole in perioperative treatment in children under 14 years –⁠ results of a questionnaire survey from practice

A recent survey among German-speaking physicians evaluated the use of non-opioid analgesics in perioperative care in children under 14 years. It focused on the use of metamizole and the monitoring of possible agranulocytosis associated with this drug.

Source: Analgesia 17. 3. 2020

News Patient with a History of DOAC Usage in Neurological ICU with Stroke –⁠ Case Study

How should we approach patients with a stroke who are taking direct oral anticoagulants (DOACs) and correctly assess the situation? When should we administer the available antidote according to guidelines? The following case study from the Regional Hospital Liberec illustrates this increasingly common situation.

Source: Anticoagulant Treatment 1. 2. 2023

News Impact of ACEi and ARBs on Lung Function in Patients with Hypertension

Worsening respiratory functions can significantly influence the choice of antihypertensive medication. A recently published study explored whether angiotensin-converting enzyme inhibitors (ACEi) can worsen lung function and whether this effect also appears with angiotensin II receptor blockers (ARBs, i.e., sartans). These findings are crucial for clinical practice, especially in treating patients at high risk for respiratory adverse effects.

Source: Sartans in the Treatment of Hypertension 4. 10. 2022

News Efficacy and Safety of Romosozumab in Postmenopausal Women with Osteoporosis and Renal Impairment

The coexistence of osteoporosis and chronic kidney disease (CKD) increases the risk of fractures and overall mortality in patients. A recent post-hoc analysis of two controlled randomized multicenter studies (FRAME and ARCH) investigated the efficacy and safety of romosozumab in postmenopausal women with osteoporosis and mild to moderate CKD.

Source: Osteoporosis – Trends in Sequential Therapy 9. 5. 2024

Články časopisu Autoimmune liver diseases in children. Part II

Author of the article: P. Dědek Source: Česko-slovenská pediatrie | 1/2011 3. 1. 2011

News Asthma and Prognosis of Patients with COVID-19

The impact of asthma, its severity, and treatment on the prognosis of patients infected with the SARS-CoV-2 coronavirus was examined in an observational study published this spring.

Source: Asthma under control 23. 9. 2021

Články časopisu Myo-inositol in the treatment of polycystic ovary syndrome

Author of the article: P. Křepelka Source: Česká gynekologie | 3/2014 18. 6. 2014

News Mechanisms of Cardioprotective Effects of SGLT2 Inhibitors

Inhibitors of sodium-glucose cotransporter 2 (SGLT2i, gliflozins) are a relatively new group of medications used in the treatment of type 2 diabetes mellitus (T2DM). Their clinical use is supported by the results of extensive clinical studies, which have particularly demonstrated their cardioprotective and renoprotective effects.

Source: Heart Failure 18. 11. 2021

News Wound Treatment Without Pain? A Rinse Solution Can Help

Patients dealing with a healing wound may fear painful dressing changes. The wound bed is exposed and highly sensitive to pain due to damaged nerve endings. By using a rinse solution, however, we can eliminate the traumatic removal of the primary dressing, making the dressing change gentler for the patient. But which solutions are suitable for this purpose and which are not?

Source: Wound Healing 25. 2. 2022

News What Did the Patent for the Synthesis of Highly Purified Trazodone Bring?

Trazodone is a modern antidepressant that is used in the treatment of various types of depression, including those accompanied by anxiety, sleep disorders, or sexual dysfunction. Angelini's invention, with patent protection valid until 2028, presents several methods for the preparation of purified trazodone, or trazodone hydrochloride, which guarantees high purity of this substance and a low content of unwanted residues.

Source: Depression and Anxiety 5. 10. 2020

News Early and effective treatment of PBC significantly reduced the need for liver transplantation due to this disease

Current European and Czech guidelines include obeticholic acid (OCA) as the only registered option for 2nd line treatment of primary biliary cholangitis (PBC). In the Czech Republic, it is approved as a center-specific treatment and was granted permanent reimbursement from public health insurance in May 2022. The use of OCA in the treatment of PBC was also addressed in a symposium that was part of the professional program at this year's XLIX. May Hepatology Days in Olomouc.

Source: Primary Biliary Cholangitis 23. 6. 2022

News How to Achieve Left Ventricular Reverse Remodeling and Improve Outcomes in Heart Failure? Summary from HFA ESC Webinar

The current treatment algorithm for chronic heart failure with reduced ejection fraction (HFrEF) is well-known to clinicians. But how was its current form developed, and does it have the potential to change in the future? Experts discussed this and more at a web symposium on reverse remodeling sponsored by Novartis during the Heart Failure Association of the European Society of Cardiology (HFA ESC) congress. Notable presenters included HFA ESC President Professor Petar Seferovic and Professor Carolyn Lam from the National Heart Centre in Singapore.

Source: Chronic Heart Failure and Lipidology 16. 9. 2020

News Three tests to confirm the diagnosis of acquired hemophilia –⁠ infographic

Acquired hemophilia (AHA) typically manifests with spontaneous bleeding in patients with no prior personal history of significant bleeding.^1–4 The cause of the bleeding is a significant decrease in FVIII activity induced by autoantibodies against coagulation factor VIII.⁵ In polymorbid patients, established antithrombotic therapy at the time of AHA diagnosis may also contribute to the bleeding.⁴

Source: Acquired Hemophilia 8. 6. 2022

News Postoperative Wound Healing

Postoperative wound healing requires sufficient attention to prevent the development of complications that could impair the final functional and aesthetic outcome. This article aims to highlight important aspects of postoperative wound care.

Source: Wound Healing 3. 9. 2020