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News Comparison of 5 Beta-Blockers in Heart Failure with Reduced Ejection Fraction

An analysis of 26 studies with beta-blockers in the treatment of heart failure with reduced ejection fraction compared 5 drugs (bisoprolol, metoprolol-succinate, metoprolol-tartrate, carvedilol, and nebivolol). The results showed a more favorable prognosis with bisoprolol compared to carvedilol, a similar effect on prognosis for carvedilol, metoprolol-succinate, and nebivolol, and the least favorable prognosis with metoprolol-tartrate.

Source: Cardiovascular Continuum 24. 4. 2024

News Population Pharmacokinetics of Perioperative Administration of Coagulation Factors in Patients with von Willebrand Disease

For many patients with von Willebrand disease, the administration of coagulation factors is an important part of perioperative care. Due to the absence of pharmacokinetic models, predicting therapeutic levels is challenging, leading to a higher risk of bleeding or thrombotic events. To create the missing model, a long-term study was conducted by Dutch authors.

Source: Von Willebrand Disease 27. 8. 2020

Články časopisu A Contemplation about the Importance of Prosthetic Defect Classification Systems in Contemporary Dentistry

Author of the article: Z. Zdráhal, J. Krňoulová, R. Slezák Source: Česká stomatologie / Praktické zubní lékařství | 4/2012 11. 7. 2012

News PHD 2022: In the treatment of multiple myeloma we have achieved significant progress, confirm real-world data

The treatment options for multiple myeloma (MM) have significantly advanced over the past 10 years, and patient outcomes have improved. However, the most accurate guide is needed to select the right treatment modality for each particular patient among the many available options. During the Prague Hematology Days (PHD) 2022, this topic was addressed by Prof. MUDr. Roman Hájek, CSc., from the Hemato-Oncology Clinic of the Faculty of Medicine at the University of Ostrava and FN Ostrava.

Source: Hematologic Malignancies 28. 3. 2022

News Gliflozins in the Treatment of Type 2 Diabetes According to Current Recommendations SVL

Gliflozins are a relatively new group of antidiabetics with a specific mechanism of action. In addition to glycemic control, they have shown favorable effects on body weight and blood pressure, minimal risk of hypoglycemia, reduced risk of heart failure, and also renal protection and cardiovascular safety. Their position in the therapeutic algorithm for type 2 diabetes is clearly defined in the 2020 recommendations of the Society of General Medicine ČLS JEP.

Source: Diabetes 24. 11. 2020

News Does Dosage Frequency Matter for Adherence to Anticholinergic Treatment in Patients with COPD?

A study by Spanish authors compared the adherence of patients with chronic obstructive pulmonary disease (COPD) to anticholinergic treatment administered once every 12 hours and once every 24 hours.

Source: Treatment of Asthma and COPD 15. 5. 2020

News Severe Polytrauma in a Man with von Willebrand Disease −⁠ Case Report

The authors of a recently published case report present a case of multiple trauma (including brain injury) in a young man with von Willebrand disease (vWD) type 2A, in whom repeated administration of a concentrate containing von Willebrand factor (vWF) and coagulation factor VIII (FVIII) led to successful healing without neurological deficit.

Source: Von Willebrand Disease 29. 11. 2022

News Current NCCN Recommendations for Classification and Risk Symptoms in SLL/CLL

The new recommendations from the National Comprehensive Cancer Network (NCCN) regarding chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) from August 2022 also include a brief summary of the most common symptoms and methods for classifying the disease based on its extent at diagnosis or in case of progression.

Source: Chronic Lymphocytic Leukemia 12. 1. 2023

News Doc. Tomáš Gabrhelík: Pain treatment should be seriously addressed by all fields, especially in seniors

Chronic pain is often underestimated, especially in older and polymorbid patients. On the other hand, during self-treatment, many patients use inappropriate medication for a long time. The treatment of prolonged and more intense pain should be managed by an algologist, and other specialists should not forget to monitor the patient's documentation to avoid medication duplication and other risks arising from inappropriate prescription. We discuss the pitfalls and benefits of analgesic treatment with doc. MUDr. Tomáš Gabrhelík, Ph.D., from the pain treatment clinic at the Department of Anesthesiology, Resuscitation, and Intensive Medicine at the Faculty of Medicine, Palacký University and University Hospital Olomouc.

Source: Analgesia 27. 9. 2023

Články časopisu Antibiotical prophylaxy in gynecology

Author of the article: J. Záhumenský, E. Menzlová, J. Zmrhal, E. Kučera Source: Česká gynekologie | 4/2013 9. 8. 2013

News SCOPE 2021 –⁠ State of Osteoporosis and Its Treatment in European Countries

The SCOPE 2021 project (The Scorecard for Osteoporosis in Europe) by the International Osteoporosis Foundation (IOF) gathered and tabulated data from 29 European countries on the burden of osteoporosis, the quality and availability of services related to the diagnosis and treatment of this disease, and the use of these services in individual states. Within the significantly heterogeneous results, the Czech Republic did not fare very well.

Source: Osteoporosis – Trends in Sequential Therapy 4. 9. 2023

News Magnetic Resonance Can Reduce the Need for Prostate Biopsies

As early as 2013, Czech experts demonstrated that in patients with elevated prostate-specific antigen (PSA) levels, imaging using a 3-Tesla magnetic resonance (3T MRI) can replace biopsy in many cases when detecting prostate cancer.

Source: Prostate Health Index 4. 6. 2020

News Efficacy and Safety of Preservative-Free Latanoprost in the Treatment of Open-Angle Glaucoma and Elevated Intraocular Pressure –⁠ Results of a Meta-Analysis

Many eye drops for the treatment of glaucoma still contain preservatives today. However, these can cause eye irritation, so non-preservative formulations should be preferred. The following meta-analysis compared the efficacy and safety of antiglaucoma medications with and without preservatives.

Source: Treatment of Glaucoma 14. 1. 2021

News Why Do Women in the USA Receive Indicated Statin Therapy Less and in Lower Doses Than Men?

Statin use has been proven to reduce the risk of cardiovascular diseases in both men and women. However, women in the USA who are indicated for this treatment have historically taken it less frequently and in lower doses than men. The current status and possible causes were investigated by the study presented below.

Source: Cardiovascular Risks 31. 1. 2020

News MUDr. Tomáš Mašek: In the prevention of hemorrhoids, more use of venopharmaceuticals is needed

While in the past the diagnosis of hemorrhoids was inextricably linked to traditional surgical solutions, today -⁠ thanks to the expansion of the indication for venopharmaceuticals for this condition -⁠ the number of patients who have to undergo these procedures is a minority. We asked coloproctologist MUDr. Tomáš Mašek how the potential of venopharmaceuticals can be utilized in the prevention and treatment of hemorrhoid disease.

Source: Venous Insufficiency 7. 11. 2023