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News Trazodone as a Multimodal and Multifunctional Antidepressant

Substances with multiple therapeutic effects, often depending on the dose, can be described as multifunctional. In low doses, trazodone has hypnotic effects, while its effective antidepressant action is evident at higher doses. This can be more frequently utilized now thanks to a modified-release formulation, which has the potential to improve the tolerability of antidepressant doses of trazodone.

Source: Depression and Anxiety 17. 3. 2020

News Targeting HER2 is Clinically Meaningful Even with Its Low Expression

Distinguishing HER2 receptor expression status on the surface of breast cancer tumor cells as simply positive or negative is now proving insufficient. Ultimately, it can lead to the non-administration of effective targeted therapy. What do we actually know about the “gray zone” between HER2 positivity and negativity?

Source: Ovarian and Breast Cancer 22. 5. 2024

News Perioperative Management of Bleeding in Patients with von Willebrand Disease Using Coagulation Factors

Von Willebrand disease is one of the most common congenital bleeding disorders. It is a heterogeneous group of diseases with varying severity of clinical manifestations. Some patients require pharmacological prevention or treatment of bleeding as part of perioperative care. The administration of concentrates containing coagulation factors is currently the gold standard for certain types of von Willebrand disease.

Source: Von Willebrand Disease 16. 12. 2020

News When Teriflunomide and Interferon Join Forces

Progressive multifocal leukoencephalopathy is a nightmare for all doctors prescribing disease-modifying therapies for multiple sclerosis. How Swiss colleagues dealt with this situation is illuminated by the following case study.

Source: Multiple Sclerosis 21. 12. 2021

News CASE STUDIES: Treatment Options for Wounds in Cancer Patients

Wounds arising due to generalized cancerous diseases or their treatments require specific procedures to support healing. To illustrate, we select three brief case studies from our practice, accompanied by rich visual material.

Source: Wound Healing 22. 8. 2022

News How Gut Microbiota Affects Thyroid Function

The composition of gut microbiota has a significant impact on the human body. Studies conducted so far have found a correlation between dysbiosis and a range of diseases, including thyroid disorders (primarily autoimmune, but also the occurrence of nodules or thyroid cancer).

Source: Thyroid Disorders 22. 9. 2021

Články časopisu Asthma and nutrition: diet for the primary prevention and treatment of asthma

Author of the article: I. Klimešová, K. Neumannová, R. Šlachta Source: Praktický lékař | 4/2012 7. 4. 2012

News Osteonecrosis of the Jaw Associated with Antiresorptive Pharmacotherapy in Oncological Patients

Antiresorptive pharmacotherapy in the form of bisphosphonates and denosumab is associated, according to current knowledge, with the risk of jaw osteonecrosis, especially following dental procedures such as tooth extractions. The aim of the newly published systematic review was therefore to evaluate the incidence of this complication following dental extractions in connection with the administration of antiresorptive medication and to identify risk factors for jaw osteonecrosis in oncological patients.

Source: Prevention of Bone Events 8. 6. 2023

News Mechanism of Action of Venopharmaceuticals and Their Use in the Treatment of Chronic Venous Insufficiency

Venopharmaceuticals are the cornerstone of conservative treatment for chronic venous insufficiency (CVD). Their mechanism of action is complex and not yet fully understood. They act on both micro -⁠ and macrocirculation, influence the tone of the venous wall, and their anti-inflammatory action is also significant.

Source: Venous Insufficiency 26. 2. 2021

News Classification and Management of Chronic Wounds

Chronic wounds are common comorbidities that increase the morbidity and mortality of patients. Common types of chronic wounds on the lower extremities include arterial, venous, and diabetic ulcers, as well as pressure ulcers. Despite their frequent occurrence, they are often poorly treated. In addition to diagnosing the etiology of chronic wounds and specific therapies, moist wound healing plays a crucial role in the treatment, such as the application of hydrocolloids and hydrogels.

Source: Wound Healing 23. 8. 2021

News MUDr. Libor Dvořáček: Microinvasiveness of surgery involves not only the method but also targeted solutions to varicose vein sources

Varicose veins, or chronic venous insufficiency of the lower extremities, are primarily a health issue, not purely a cosmetic one. This is because they are associated with the risk of complications that necessitate long-term therapy and complex treatment of these issues. As MUDr. Libor Dvořáček, the head physician of the Vasmedic Clinic, mentions in our brief interview on this topic, the approach of health insurance companies and the Ministry of Health has fortunately been changing in favor of day surgery –⁠ that is, microinvasive and much gentler surgery.

Source: Venous Insufficiency 17. 12. 2023

News Micronized Diosmin and Flavonoid Fraction –⁠ What Do They Have in Common?

Micronized diosmin and micronized purified flavonoid fraction are medications from the flavonoid group that are used as venopharmaceuticals/venoprotectives in the treatment of chronic venous insufficiency and hemorrhoidal disease. Both have many common properties, which we discuss in the following text. Their differences will be covered in a follow-up article on this topic.

Source: Venous Insufficiency 22. 2. 2021

News Sustained Remission of ITP with Thrombopoietin Receptor Agonists Treatment

Thrombopoietin receptor agonists (TPO-RAs) are highly effective drugs administered in chronic immune thrombocytopenia (ITP). Several studies have shown that they can induce remission and long-term response, even after prolonged discontinuation.

Source: Immune Thrombocytopenia 15. 9. 2020

News Overall Survival and Tolerance of Olaparib in the OlympiAD Study –⁠ Results of Extended Follow-up

Olaparib provides women with metastatic breast cancer with a germline BRCA mutation, who have not been pre-treated with chemotherapy, not only with extended progression-free survival but also, according to the latest reports, longer overall survival. Its tolerability is good over the long term.

Source: Ovarian and Breast Cancer 28. 5. 2020

News Diabetes mellitus and heart failure −⁠ interconnected units with complex pathogenesis

Diabetes mellitus (DM) represents a significant risk factor for the development of heart failure. The pathogenesis of this condition is very complex, involving hyperglycemia and other metabolic abnormalities, as well as frequently occurring comorbidities such as hypertension, ischemic heart disease, or diabetic neuropathy. The development of type 2 DM (T2DM) in patients with heart failure (cardiogenic T2DM) is also quite common and is primarily caused by the resistance of peripheral tissues to insulin. The result of cardiogenic DM is further progression and a worse prognosis of heart failure. Recent findings on this topic have been summarized by Greek experts in their review article for Journal of Clinical Medicine.

Source: Heart Failure 12. 1. 2023