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News Patient with Generalized Melanoma Treated with Nivolumab with Long-Term Response after Previous Failure of Combined Chemoimmunotherapy

Source: Case Studies from Immunooncology 11. 9. 2020

News Lactobacillus reuteri −⁠ a natural probiotic with lifelong significance

Probiotics are often given to newborns within the first few days of life to alleviate infantile colic. However, the role of probiotic treatment in protecting infants from infections, even into their adult life, is a growing area of research interest. Which natural probiotic strains have verified immunomodulatory properties and is it suitable to administer them alongside breast milk?

Source: GI, colic and microbiome 16. 2. 2021

Články časopisu Amniotic fluid embolism –⁠ review

Author of the article: A. Černý, A. Pařízek, Patrik Šimják Source: Česká gynekologie | 4/2014 1. 8. 2014

Články časopisu Radiotherapy and radiosensitivity syndromes in DNA repair gene mutations

Author of the article: R. Lohynská, Z. Pechačová, E. Mazaná, J. Čejková, A. Nováková-Jirešová, J. Hornová, M. Langová Source: Klinická onkologie | 2/2022 12. 4. 2022

Články časopisu Examination of circulating tumor cells in renal carcinoma

Author of the article: Petr Klézl, Jindřich Šonský, Eliška Pospíšilová, Katarína Kološtová, Vladimír Bobek, Robert Grill Source: Česká urologie | 2/2020 11. 6. 2020

News ACC 2023 Expert Consensus: How to Optimize Diagnosis and Treatment of Heart Failure with Preserved EF LK

Heart failure (HF) remains a significant cause of morbidity and mortality, with the incidence and prevalence of HF with preserved left ventricular ejection fraction (HFpEF) rising. The following document focuses on individuals with HFpEF and supports the principles of evidence-based diagnosis and treatment of HF from 2022. It emphasizes the need for individualized care and multidisciplinary cooperation.

Source: Heart Failure 14. 3. 2024

Články časopisu Cerebral venous thrombosis during pregnancy

Author of the article: V. Smetanskyi, A. Šefčíková, A. Dörr Source: Česká gynekologie | 2/2018 4. 6. 2018

News Treatment of Immune Thrombocytopenia: Choice of TPO Mimetics in Clinical Practice

Real-world data show that the administration of thrombopoietin receptor agonists in immune thrombocytopenia leads to a high percentage of treatment responses, and in some patients, it is possible to achieve a stable response without the need for further treatment after discontinuation.

Source: Immune Thrombocytopenia 20. 2. 2020

Články časopisu

Author of the article: Martin Pretl, Zuzana Lattová, Andrea Plíhalovájan Polák, Kateřina Westlake Source: Časopis lékařů českých | 5/2019 7. 11. 2019

News Prediabetes through the lens of current data and findings −⁠ and why hurry with intervention

Type 2 diabetes mellitus (DM2) is one of the most common causes of premature morbidity and mortality worldwide. The most serious impact on the health of the organism is mainly due to the macrovascular complications of this disease. However, their occurrence was often recorded before the diagnosis of DM2 was confirmed. Prediabetes itself thus represents a condition associated with the risk of developing cardiovascular (CV) complications with all their prognostic implications for patients.

Source: Diabetes 27. 7. 2022

News Complete remission of ALK-positive lung cancer in a patient after multiple lines of targeted therapy –⁠ a case study

Targeted treatment for driving oncogenic mutations has significantly improved outcomes for patients with ALK-positive non-small cell lung cancer (NSCLC) as well. A case study was recently published in the journal Frontiers in Oncology of a patient with advanced disease who achieved complete remission after several lines of therapy.

Source: Genetic Profile and Treatment of NSCLC 27. 12. 2021

News Carpal Tunnel Syndrome as a Warning Sign of Cardiomyopathy Caused by Transthyretin Amyloidosis

Recent study results suggest that transthyretin amyloidosis is a more common cause of heart failure than previously thought. Early diagnosis and subsequent therapy are key to improving patient prognosis. A comprehensive study evaluating data from the Danish population registry suggests that carpal tunnel syndrome may be one of the initial symptoms of the disease.

Source: Amyloidosis 2. 3. 2023

News Trazodone as a Multimodal and Multifunctional Antidepressant

Substances with multiple therapeutic effects, often depending on the dose, can be described as multifunctional. In low doses, trazodone has hypnotic effects, while its effective antidepressant action is evident at higher doses. This can be more frequently utilized now thanks to a modified-release formulation, which has the potential to improve the tolerability of antidepressant doses of trazodone.

Source: Depression and Anxiety 17. 3. 2020

News Targeting HER2 is Clinically Meaningful Even with Its Low Expression

Distinguishing HER2 receptor expression status on the surface of breast cancer tumor cells as simply positive or negative is now proving insufficient. Ultimately, it can lead to the non-administration of effective targeted therapy. What do we actually know about the “gray zone” between HER2 positivity and negativity?

Source: Ovarian and Breast Cancer 22. 5. 2024

News Perioperative Management of Bleeding in Patients with von Willebrand Disease Using Coagulation Factors

Von Willebrand disease is one of the most common congenital bleeding disorders. It is a heterogeneous group of diseases with varying severity of clinical manifestations. Some patients require pharmacological prevention or treatment of bleeding as part of perioperative care. The administration of concentrates containing coagulation factors is currently the gold standard for certain types of von Willebrand disease.

Source: Von Willebrand Disease 16. 12. 2020