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News Diagnosis and Management of Therapy for a Breastfeeding Patient with Significant Elevation of Liver Enzymes Postpartum – Interactive Case Study
In the following case study, we present a specific approach to a patient who developed a significant elevation of liver enzymes after childbirth. Through interactive elements, you can try out how you would proceed in diagnosing and treating this case.
News Is the Quality of Life for Patients with Atrial Fibrillation and Heart Failure Comparable When Treated with Bisoprolol and Digoxin?
The British RATE-AF study, published in December 2020 in the JAMA journal, compared the impact on improving the quality of life in patients with permanent atrial fibrillation (AF) and symptoms of heart failure when administering bisoprolol and low-dose digoxin.
News Meta-analysis of the Metabolic Effects of Second-generation Antipsychotics
Second-generation antipsychotics used in the therapy of schizophrenia exhibit varying metabolic profiles. A recently conducted meta-analysis by Italian authors investigated the impact of second-generation antipsychotics on weight gain, BMI, lipid spectrum, and glycemia.
News Complete remission of ALK-positive lung cancer in a patient after multiple lines of targeted therapy – a case study
Targeted treatment for driving oncogenic mutations has significantly improved outcomes for patients with ALK-positive non-small cell lung cancer (NSCLC) as well. A case study was recently published in the journal Frontiers in Oncology of a patient with advanced disease who achieved complete remission after several lines of therapy.
News Administration of Fibrinogen Concentrate in Patients with Persistent Bleeding After Cardiac Surgery
Is the administration of fibrinogen concentrate in patients with persistent bleeding after initial cardiac surgery associated with an increased risk of thromboembolic events or death? Authors of a Swedish observational study published last year aimed to answer this question.
News Quality of Life of Patients on Adjuvant Treatment for HER2-Positive Breast Cancer
The KATHERINE clinical trial demonstrated that adjuvant therapy with trastuzumab emtansine compared to trastuzumab significantly improves invasive disease-free survival in patients with HER2-positive early breast cancer and residual invasive disease after prior treatment. A post hoc analysis of this study was published in the journal Cancer, focusing on patient-reported outcomes related to quality of life during and after treatment.
News How do IL-17 and IL-23 inhibitors fare in the treatment of psoriasis in direct comparison?
A recent study published in the British Journal of Dermatology is only the second paper to provide a direct comparison of the efficacy and onset speed of treatment with IL-17 and IL-23 inhibitors in patients with moderate to severe plaque psoriasis. The authors monitored the early response to treatment (at week 12), and the efficacy and safety of ixekizumab and guselkumab.
News Metamizole in perioperative treatment in children under 14 years – results of a questionnaire survey from practice
A recent survey among German-speaking physicians evaluated the use of non-opioid analgesics in perioperative care in children under 14 years. It focused on the use of metamizole and the monitoring of possible agranulocytosis associated with this drug.
News Does Sacubitril/Valsartan Prevent Myocardial Remodeling in Heart Failure Patients with Type 2 Diabetes?
The PROVE-HF study demonstrated reverse myocardial remodeling in patients with chronic heart failure with reduced ejection fraction. About 30–50% of heart failure patients have type 2 diabetes mellitus (DM2). The subject of a post hoc analysis of the PROVE-HF study was to find out whether this benefit of sacubitril/valsartan can be expected in patients with DM2 as well.
News Lung screening in the Czech Republic has detected over a hundred cases of lung cancer
The purpose of lung screening, which has been ongoing in the Czech Republic since January 2022, is to detect early stages of lung cancer and increase awareness of this malignant disease in relation to smoking. Data analysis from health insurance companies through the National Registry of Paid Health Services (NRHZS) revealed that out of nearly 4,000 individuals who underwent low-dose CT as part of the screening examination, 116 were diagnosed with cancer.
News Clinical and Microbiological Effect of L. reuteri in the Treatment of Chronic Periodontitis
The Journal of Clinical Periodontology published the results of a study evaluating the effect of the probiotic bacterial strain Lactobacillus reuteri as an adjunctive treatment for chronic periodontitis.
News Consolidation therapy with brentuximab vedotin after autologous stem cell transplantation in patients with relapsed/refractory Hodgkin lymphoma
At the 12th International Symposium on Hodgkin Lymphoma (ISHL), held in October 2022 in Cologne, results of a Czech study evaluating the efficacy and safety of consolidation therapy with brentuximab vedotin in patients after autologous stem cell transplantation were presented.
News Facilitated Immunoglobulin Substitution Therapy in Paediatric Patients with Immunodeficiency – Real-World Data
Patients with humoral immunodeficiency are indicated for immunoglobulin substitution therapy. The study presented below summarizes real-world data concerning the latest substitution method (i.e., facilitated subcutaneous administration) in paediatric patients.
News Transfer of Microbiome from Mother to Child: A Key but Fragile Process
How does the transfer of gut microbiota between mother and child occur? Is this transfer clinically significant, and what factors can disrupt it? These questions are addressed in a 2019 review article by Dutch microbiologists.
News Young man with nephrotic syndrome and portal vein thrombus successfully treated with edoxaban − case report
Venous thrombosis is one of the main complications of nephrotic syndrome (NS), though it is most often located in the renal vein. The following case report describes an adult patient with relapsing corticosteroid-dependent minimal change disease complicated by portal vein thrombosis and subsequent successful treatment with edoxaban.
News Role of Transthyretin in the Development of Amyloidosis
Transthyretin (TTR), one of the transport proteins, tends to form extracellular deposits that accumulate in key organs, such as the heart and nerves. The formation of TTR deposits leads to the development of systemic amyloidosis, a disease with highly heterogeneous clinical manifestations. Warning signs may include carpal tunnel syndrome, among others. What is the physiological role of TTR in the body and what role does its structure play in the development of amyloidosis?
News Experiences with Long-term Treatment of Psoriasis with Interleukin 17A Inhibitor
The current publication of the long-term extension of the UNCOVER-3 study, which focused on the treatment of psoriasis with ixekizumab, describes the efficacy and safety of 4 years of use of this drug.
News News in the Treatment of Allergic Rhinitis
According to literary sources, 17–28.5% of Europeans suffer from allergic rhinitis (AR), which negatively affects the quality of daily life. Below, we summarize the new recommendations from ARIA (Allergic Rhinitis and its Impact on Asthma) from 2019 regarding the treatment of this condition and highlight a new therapeutic option offered by the fixed combination of mometasone furoate with olopatadine hydrochloride.
News MUDr. Libor Dvořáček: Microinvasiveness of surgery involves not only the method but also targeted solutions to varicose vein sources
Varicose veins, or chronic venous insufficiency of the lower extremities, are primarily a health issue, not purely a cosmetic one. This is because they are associated with the risk of complications that necessitate long-term therapy and complex treatment of these issues. As MUDr. Libor Dvořáček, the head physician of the Vasmedic Clinic, mentions in our brief interview on this topic, the approach of health insurance companies and the Ministry of Health has fortunately been changing in favor of day surgery – that is, microinvasive and much gentler surgery.
News Current Indications for Negative Pressure Therapy in Wound Healing in Orthopedic and Traumatological Patients
Negative pressure wound therapy was introduced in North America in 1997. Since then, the method has gained great popularity and is used in the treatment of many acute and chronic wounds. Like any other treatment modality, it has its proper indications and contraindications. An overview article by French authors evaluates the current use of negative pressure therapy in the fields of orthopedics and trauma of the musculoskeletal system.
News Fibrinogen and Management of Peripartum Life-Threatening Hemorrhage
The most common cause of maternal death in the developed world continues to be peripartum life-threatening hemorrhage. It can result as a consequence of the consumption of coagulation factors, primarily fibrinogen. The analysis presented below summarizes information on the prevention of this complication and the use of fibrinogen concentrate therapy.
News When Size Matters or What Is Small Is Effective
The systemic effect of an orally administered drug can be expected, among other things, if it has suitable physicochemical properties. How can insufficient absorption or poor solubility be solved? We provide the answer below.