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News Initial Treatment for Newly Diagnosed ITP Patients at a Glance

The revised international consensus on the management of primary immune thrombocytopenia (ITP) from 2019 outlines several points summarizing suitable initial treatment for newly diagnosed individuals with ITP.

Source: Immune Thrombocytopenia 21. 2. 2023

News Index of Prostate Health as a Predictive Biomarker of Biopsy Outcome

As demonstrated by Spanish authors in their work published at the beginning of 2018, the Prostate Health Index (PHI) is a biomarker that can refine the prediction of prostate biopsy outcomes in men with elevated prostate-specific antigen (PSA) levels.

Source: Prostate Health Index 2. 4. 2020

News Tapentadol Hydrochloride in Clinical Practice –⁠ To Whom, When, How, and Why?

Thanks to its specific properties, tapentadol hydrochloride ranks among the most effective opioids for managing chronic non-cancer pain. Unlike most opioids, it also exhibits an analgesic effect in neuropathic pain. The following brief overview summarizes its mechanism of action and resulting benefits, reimbursement and prescription conditions, its place in the pain management algorithm, and examples of its application in clinical practice.

Source: Updates in Pain Treatment 12. 10. 2023

News Discontinuation of Methotrexate After Initiation of Tofacitinib in the Treatment of Rheumatoid Arthritis

New real-world data show that in patients with rheumatoid arthritis (RA) who started treatment with tofacitinib combined with oral methotrexate (MTX), it is possible to discontinue MTX and achieve the same treatment results as with its continued use, additionally at lower costs.

Source: Arthritis 27. 7. 2022

News Position of Levodropropizine in Cough Therapy

An international group of specialists focused in 2016–2017 on a detailed evaluation of current options for cough therapy. The authors based their analysis on individually prepared reviews using Medline and Embase databases, and they presented their work's results last year in the journal Pulmonary Pharmacology & Therapeutics.

Source: Cough Therapy 15. 1. 2020

News Deficit dihydropyrimidine dehydrogenase and its association with 5-fluorouracil toxicity

Deficit dihydropyrimidine dehydrogenase (DPD) is a risk factor for severe toxicity of 5-fluorouracil (5-FU). Below, we summarize current knowledge regarding the identification of patients with pathogenic variants of the DPYD gene and study results concerning the safety of therapy with respect to dose individualization based on genotyping.

Source: Genetics 12. 6. 2023

News Non-factor vs. Factor Prophylaxis of Hemophilia A: A Comparison of Cost and Treatment Effectiveness Based on Real-World Data from the USA

In the prophylactic treatment of patients with hemophilia A, particularly its severe form, concentrates of clotting factor VIII (FVIII) with extended half-life (EHL) are increasingly administered, or non-factor treatment, represented in clinical practice by FVIII mimetic antibody emicizumab. However, insights into the direct comparison of effectiveness and economic burden arising from prophylaxis with these modalities are limited, including data from real-world practice. One recently published study therefore attempted to conduct such a retrospective comparison based on data from healthcare-related databases in the USA.

Source: Hemophilia 30. 6. 2023

News Effect of Short-Term and Long-Term Stress on Heart Rate Variability

Acute and chronic stress significantly affects the cardiovascular (CV) system. The study presented below examines the effects of both acute and chronic stress on heart rate variability in 50 healthy individuals.

Source: Cardiovascular Continuum 13. 4. 2021

Články časopisu Menstrual migraine (migraine without aura): diagnostic and possibility of hormonal treatment

Author of the article: Ingrid Niedermayerová Source: Praktická gynekologie | 1/2012 22. 1. 2012

News Options of Anticoagulant Therapy During Pregnancy: Focus on Fondaparinux

The use of most medicinal products is limited during pregnancy either by known teratogenic effects or by lack of safety data for the mother and fetus. A systematic review by authors from the University of Liverpool provides information on the options for anticoagulant treatment during pregnancy.

Source: Management of Thrombosis in Women 24. 3. 2020

Články časopisu Probiotics in gynaecology

Author of the article: Tomáš Fait Source: Praktická gynekologie | 2/2011 7. 6. 2011

News Ultrasound in a Patch –⁠ Smart System Capable of Monitoring Patient During Regular Activities

A team of scientists from the University of California, San Diego, has developed a miniature autonomous ultrasound system that, when attached to the skin, can visualize tissue located deep beneath the body’s surface. It could be used for continuous monitoring of blood pressure, heart activity, and respiratory parameters in real time, whether during regular activities or intense physical exertion.

Source: 25. 4. 2024

News Efficacy and Tolerance of Dorzolamide/Timolol Combination With and Without Preservatives in Patients With Elevated Intraocular Pressure

The fixed combination of the carbonic anhydrase inhibitor dorzolamide and the locally acting beta-blocker timolol is indicated for the treatment of elevated intraocular pressure in patients with open-angle glaucoma. The comparison of the efficacy and tolerance of this combination with preservatives, associated among other things with eye irritation, and without them was the subject of the American study presented below.

Source: Treatment of Glaucoma 21. 8. 2020

News What is the significance of hormones in the pathophysiology of migraine?

Migraine is a complex neurovascular disease characterized by the dysfunction of the nociceptive trigeminovascular system in its pathophysiology. Its prevalence is 2-3 times higher in women than in men. The cause of this difference has not yet been fully elucidated, but it appears that the fluctuation of ovarian hormone levels and its influence on CGRP plays an important role. The following article summarizes findings on the hormonal influence of migraine and also discusses new prophylactic drugs –⁠ anti-CGRP antibodies.

Source: Migraine 27. 7. 2020

News Interactive Case Study: Use of Cannabis Extract for Local Treatment of Neuropathic Pain

We have been using cannabis for pain treatment for several years. We also have good experiences with it in difficult-to-control symptoms of neuropathic pain, as illustrated in the following case study. Until recently, our patients only used cannabis orally or via vaporization. With the availability of cannabis extracts, a new option has emerged –⁠ local therapy.

Source: Medical Cannabis 19. 6. 2024