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News Diagnosis, Treatment, and Outcomes Achieved in Patients with Non-Small-Cell Lung Cancer in Central Europe

In June 2020, the journal Radiology and Oncology published the results of an analysis of data from patients with stage III non-small-cell lung cancer (NSCLC) from a Central European registry. A large team led by Czech experts focused on the diagnostic and therapeutic procedures used and the treatment results achieved in real-world practice.

Source: Lung Cancer 6. 1. 2021

News Can the use of sartans reduce mortality and severity of COVID-19 in hypertensives?

Existing scientific and clinical evidence suggests the involvement of the renin-angiotensin-aldosterone system (RAAS) in the pathophysiology of COVID-19. Some of the initial experimental therapy proposals included various interventions in the RAAS.

Source: Sartans in the Treatment of Hypertension 21. 7. 2022

News Immunotherapy of Cancer Diseases

Immunotherapeutic strategies have been successfully utilized recently in the treatment of various malignancies. Increasing understanding of the interactions between the tumor and the host organism over the last few years has led to proposals of various promising therapeutic approaches. This overview briefly summarizes the basic principles of immunotherapy for cancer diseases.

Source: Immunotherapy in Oncology 1. 10. 2020

News Diagnosis of AAT Deficiency According to Italian Recommendations and a Clear Algorithm for Practice

Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that primarily affects the lungs and liver. It is considered a rare disease, but it is also significantly underdiagnosed. Given the availability of specific treatment, which involves the administration of purified alpha-1 antitrypsin (AAT) derived from human plasma in patients with COPD due to AATD, identifying these patients is crucial. We summarize the recently issued Italian recommendations for the diagnosis of AATD and place them in the context of Czech standards.

Source: Deficiency of Alpha-1-Antitrypsin 1. 11. 2022

News Detection of ceftazidime/avibactam-resistant Enterobacteriaceae strains using a new rapid test

Ceftazidime/avibactam (CZA) is a relatively new antibiotic with very good efficacy against carbapenem-resistant Enterobacteriaceae. Unfortunately, strains resistant to this antimicrobial treatment are now beginning to emerge. The authors of the presented study developed and tested a new laboratory test for the rapid and accurate detection of these multidrug-resistant Enterobacteriaceae.

Source: Anti-Infectives 15. 5. 2023

News The Importance of Hydration in Wound Healing

In response to skin injury, bodily processes initiate to restore the function of the skin barrier, minimize fluid loss, and ensure optimal hydration. Studies have shown that wounds maintained in a moist or hyperhydrated environment heal faster than those left to dry in the air. Research further suggests that the harmful effects of exudate in poorly healing wounds are not due to the water itself, but to the biological components contained in the exudate.

Source: Wound Healing 13. 10. 2022

News Inclisiran −⁠ a new addition to the arsenal of dyslipidemia treatment

At the XXIX Congress of the Czech Society of Internal Medicine ČLS JEP, held November 6−9, 2022 in Prague, lectures on innovative dyslipidemia therapy using the small interfering RNA molecule −⁠ inclisiran were presented at the Novartis company symposium.

Source: Chronic Heart Failure and Lipidology 23. 12. 2022

News Expression of PD-L1 in Patients with Advanced Non-Small Cell Lung Cancer

An international team of authors published a systematic review addressing the relationship between the programmed cell death receptor ligand (PD-L1) and important clinical characteristics of patients with non-small cell lung cancer (NSCLC), the significance of PD-L1 expression for NSCLC prognosis, and the potential use of this biomarker to predict the response of patients with advanced/metastatic NSCLC to therapies targeting the PD-1/PD-L1 pathway.

Source: Immunotherapy in Oncology 14. 11. 2020

News Incidence of Osteoporosis in Patients with Atrial Fibrillation Treated with Different Oral Anticoagulants

Previous research has suggested an increased risk of osteoporosis and osteoporotic fractures in patients with atrial fibrillation treated with warfarin. A recent analysis also identified a higher incidence of osteoporosis in patients treated with warfarin or direct oral anticoagulants (DOACs). However, less is known about the risk of this disease when using DOACs compared to warfarin. Therefore, Australian doctors compared its incidence in patients treated with different oral anticoagulants for atrial fibrillation (AF) in a population cohort study using data from a nationwide primary care database.

Source: Anticoagulant Treatment 16. 10. 2023

News Meta-analysis of Efficacy and Safety of Antidiabetics in Treating Gestational DM

What efficacy and safety do insulin, metformin, or the sulfonylurea derivative glibenclamide (glyburide) offer in lowering glucose levels in women with gestational diabetes? The authors of a meta-analysis of randomized controlled trials used a probabilistic model –⁠ a Bayesian network –⁠ to answer this question.

Source: Modern Treatment of Diabetes 13. 9. 2023

News Current and Future Possibilities for Influencing Immune Thrombocytopenia

The possibilities for treating immune thrombocytopenia (ITP) are quite broad today, with a major advancement for many patients being the advent of thrombopoietin receptor agonists. However, for some patients, optimal treatment is still not available, and their hope lies in further research.

Source: Immune Thrombocytopenia 16. 5. 2022

Články časopisu Current treatment options for hepatocellular carcinoma

Author of the article: MUDr. Kubala Eugen Source: Klinická onkologie | Supplementum 3/2020 31. 10. 2020

Články časopisu Efficiency of Robot-assisted Therapy through the Device Armeo Spring in Patients after Stroke in Acute Phase of Early Rehabilitation

Author of the article: R. Bocanová, T. Gueye, O. Švestková, A. Oktábcová Source: Rehabilitation & Physical Medicine | 3/2018 23. 8. 2018

News Comparison of Enoxaparin and Unfractionated Heparin in Hospitalized Patients in Terms of Clinical and Cost Effectiveness

Thromboembolic disease represents one of the severe complications in hospitalized patients. Low molecular weight and unfractionated heparin are most commonly used during hospitalization as part of pharmacological thromboprophylaxis. An extensive study conducted in the United States evaluated the clinical and cost-effectiveness and safety of both therapy modalities in hospitalized patients at risk of thromboembolic disease.

Source: Thromboprophylaxis 31. 3. 2022

News Metamizole in Pain Management for Patients with Subarachnoid Hemorrhage

A study by Czech authors from the University Hospital St. Anna in Brno, recently published in the British Journal of Neurosurgery, evaluated analgesic treatment in patients with subarachnoid hemorrhage. The use of metamizole as the primary analgesic was associated with a significantly lower risk of adverse clinical outcomes at 2 weeks and 6 months compared to other non-opioid and opioid analgesics.

Source: Analgesia 10. 5. 2023