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News Wound Healing and Exudate –⁠ A Comprehensive Look at Moisture Management in Wounds

Exudate produced during the inflammatory phase of healing is a crucial factor that ensures a moist environment in the wound, provides nutrients for cellular metabolism, and supports autolytic debridement. Without proper exudate management and maintenance of optimal moisture in the wound, patients are exposed to a range of risks and complications in healing.

Source: Wound Healing 14. 12. 2023

News Adequate Compensation of a Hypertensive Patient According to Current ESC Guidelines –⁠ Case Study

A 65-year-old man, hypertensive, visits the general practitioner for a check-up. He reports recent shortness of breath during mild exertion (walking up stairs). Two months ago, he had acute sinusitis, for which he was prescribed antibiotics (penicillin V) by a specialist. He experiences hip pain and suffers from a runny nose in the spring (allergy?). He has been treated for hypertension for approximately 8 years.

Source: Sartans in the Treatment of Hypertension 29. 9. 2020

Články časopisu Treatment strategies for myelodysplastic syndrome in 2021

Author of the article: Petra Bělohlávková Source: Vnitřní lékařství | 3/2021 21. 6. 2021

News INFOGRAPHIC: Determining the Target Intraocular Pressure in Glaucoma Therapy

The goal of glaucoma treatment is to preserve the visual field and the quality of life of patients. Currently, the only approach to preserving the visual field of patients is to reduce intraocular pressure (IOP). Its target value should be determined for each patient with consideration of individual risk factors. The following comprehensive infographic shows which factors should be considered according to the current recommendations of the European Glaucoma Society (EGS).

Source: Treatment of Glaucoma 14. 7. 2023

News INFOGRAPHIC: Diagnosis and Monitoring of Patients with Hypertrophic Cardiomyopathy –⁠ Current Guidelines

What examinations should be conducted when suspecting hypertrophic cardiomyopathy, a hereditary disease caused by mutations in genes encoding cardiac muscle proteins? What is the subsequent procedure for monitoring patients and their at-risk relatives? The comprehensive infographic summarizes the current recommendations of American professional societies.

Source: Hypertrophic Cardiomyopathy (HCM) 1. 11. 2023

News Combined Treatment of Chronic Lymphocytic Leukemia in Frail Patients –⁠ Results from Real-World Clinical Practice

Treatment of older patients and those with chronic lymphocytic leukemia (CLL) who are not in good physical condition has advanced significantly in recent years. The addition of obinutuzumab to chlorambucil therapy has extended both progression-free survival and overall survival for patients. The authors of the presented study evaluated the efficacy and safety of obinutuzumab in real-world clinical practice.

Source: Non-Hodgkin Lymphomas and CLL 11. 5. 2020

News Autonomic Dysfunction in Patients with Transthyretin Amyloidosis

Autonomic nervous system disorders are a common complication of transthyretin amyloidosis. Their frequency, nature, and impact on patients' quality of life were examined in the longitudinal THAOS study.

Source: Amyloidosis 12. 7. 2022

Články časopisu Importance of outpatient ultrasonografically guided transvaginal hydrolaparoscopy in the decision algorithm of care for the infertile couple.
The results of the Centre for Assisted Reproduction Gennet Liberec 2012–2013

Author of the article: V. Mokrá, I. Petr, J. Soukeník Source: Česká gynekologie | 3/2014 18. 6. 2014

News Comparison of Pharmacological Properties of Micronized Diosmin and Hesperidin in the Treatment of Chronic Venous Insufficiency and Hemorrhoids

Diosmin and hesperidin belong to the group of bioflavonoids, which currently find wide application in the treatment of chronic venous insufficiency and hemorrhoidal disease. Both flavonoids have been described to have a similar, but still not fully understood mechanism of action. Nevertheless, diosmin significantly differs from hesperidin, especially in pharmacokinetic parameters, which makes it the main carrier of the effect of venotonics.

Source: Venous Insufficiency 6. 10. 2020

News Efficacy of Dabigatran on Left Atrial Appendage Thrombus in Patients with Atrial Fibrillation

The direct thrombin inhibitor dabigatran has shown interesting efficacy in a smaller clinical study in patients with atrial fibrillation and a thrombus in the left atrial appendage. Chinese authors evaluated the results of anticoagulant therapy using transthoracic and transesophageal echocardiography.

Source: Anticoagulant Treatment 22. 2. 2021

News Probiotics as a Means to Reduce the Incidence of Streptococcus Mutans

Data from a prospective study examining the effects of probiotics on the oral microbiome show the ability of orally administered probiotics to reduce the incidence of Streptococcus mutans and also positively affect the presence of lactobacilli in the oral cavity.

Source: GI, colic and microbiome 19. 4. 2022

News Results of Long-Term Follow-Up of Patients with Prostate Adenocarcinoma After Radiotherapy with Short-Term Androgen Deprivation

Adding short-term androgen deprivation to radiotherapy improved overall survival, disease-specific mortality, and the incidence of distant metastases in men diagnosed with prostate adenocarcinoma. Subsequent analysis investigated whether the beneficial effect of androgen deprivation is long-lasting.

Source: Oncological Treatment 21. 3. 2023

News Where radical surgery cannot be performed in the subhepatic region or liver, there is room for radiation treatment

Proton radiotherapy continues to expand its indications in the treatment of oncological diseases. In the following interview, we focus on its role in treating tumors in the subhepatic region. MUDr. Pavel Vítek, Ph.D., MBA, from the Proton Center Prague (PTC), shared his perspective on this modality and his experiences at his workplace.

Source: Proton Radiotherapy 10. 4. 2024

News Instead of NSAIDs, consider combining paracetamol with a weak opioid

Chronic non-cancer pain is a problem that primary care physicians encounter on a daily basis. In the following interview with general practitioner MUDr. Michaela Wichová, we discuss how to approach a patient who complains of pain, what to remember during examination, and which analgesics are appropriate to start treatment.

Source: Updates in Pain Treatment 1. 11. 2023

News Allergic Rhinitis in the General Practitioner’s Office: How to Proceed in Primary Care?

Up to 60% of the population has a genetic predisposition to allergic disease. Diagnosis and therapy of allergic conditions are therefore very common topics in primary care. How should we proceed correctly in the diagnostic process when suspecting allergic rhinitis? When to refer to a specialist and what are the treatment options?

Source: Life Without Allergic Rhinitis 7. 6. 2022