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News Newer Beta Blockers Offered for Use in Atherosclerosis Prevention
An article highlighting recent scientific findings on the beneficial effects of beta-blockers (BB) directly on the arterial wall and the potential benefit for the prevention of atherosclerotic cardiovascular disease (ASCVD) by adding BB to already established strategies for treating dyslipidemia and diabetes was published this year in the journal Current Atherosclerosis Reports.
News Obeticholic Acid in the Treatment of Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid in Real Practice
An interim analysis of the OCARELIFE observational study presented at the European Association for the Study of the Liver (EASL) congress in August 2020 attempted to evaluate whether the safety and efficacy of obeticholic acid treatment in patients with primary biliary cholangitis (PBC) under real-life conditions after 12 months correspond to the results of clinical trials.
News Practical Two-Point Pharmacokinetic Protocol in Hemophilia A
A recently published study confirmed the practicality of a shortened and simple pharmacokinetic protocol for patients with hemophilia A.
News Initial Treatment for Newly Diagnosed ITP Patients at a Glance
The revised international consensus on the management of primary immune thrombocytopenia (ITP) from 2019 outlines several points summarizing suitable initial treatment for newly diagnosed individuals with ITP.
News Extract from Aloe barbadensis in the Treatment of Irritable Bowel Syndrome
The authors of a pooled analysis of two randomized controlled trials evaluated whether administration of Aloe barbadensis extract in patients with diarrhea-predominant irritable bowel syndrome (IBS) resulted in a significant reduction in the overall severity of symptoms.
News Pregabalin in the Treatment of Postherpetic Neuralgia Resistant to Gabapentin
Pregabalin appears to be an effective aid in patients with postherpetic neuralgia. This is evidenced by numerous clinical studies comparing the effects of pregabalin and gabapentin. It can be expected to alleviate painful symptoms and improve sleep quality, thereby significantly enhancing patients' quality of life.
News Advances in the Treatment of Myasthenia Gravis on the Horizon
The research of new drugs for the generalized form of myasthenia gravis has made significant progress in recent years. How is the new specific therapy performing? And are we heading towards a radical change in treatment strategy?
News Simple antiemetic prophylaxis for breast cancer patients treated with AC chemotherapy
The combination of an anthracycline cytostatic agent with cyclophosphamide (AC) is among the highly effective chemotherapy regimens for breast cancer. Individually, these cytostatic agents carry a moderate risk of emetogenicity; however, when combined, they are considered to be at high risk of emesis. The recommended prophylaxis involves administering a 5-HT3 serotonin receptor antagonist in combination with an NK1 neurokinin receptor antagonist and the corticosteroid dexamethasone.
News Pregabalin in the Hands of a General Practitioner
A recent Cochrane systematic review by authors from Oxford University examined the effect of pregabalin in the treatment of postherpetic neuralgia and diabetic neuropathy – conditions that general practitioners frequently encounter in their practice. Is pregabalin a suitable choice in these indications?
News Ultrasound in a Patch – Smart System Capable of Monitoring Patient During Regular Activities
A team of scientists from the University of California, San Diego, has developed a miniature autonomous ultrasound system that, when attached to the skin, can visualize tissue located deep beneath the body’s surface. It could be used for continuous monitoring of blood pressure, heart activity, and respiratory parameters in real time, whether during regular activities or intense physical exertion.
News Prediction of Cancer Aggressiveness: Prostate Health Index (PHI) as a Promising Future Marker
The Prostate Health Index (PHI) is a diagnostic blood test that combines the levels of prostate-specific antigen (PSA), free PSA (fPSA), and the isoform [-2]proPSA (p2PSA). Its use in prostate cancer diagnostics can reduce the number of unnecessary prostate biopsies compared to determining PSA alone. A recently published Czech study assessed the utility of PHI in evaluating the aggressiveness of prostate cancer. The study compared PHI values with the results of preoperative biopsy and postoperative prostate histology in men indicated for radical prostatectomy.
News Reference Intervals of Prostate Health Index (PHI) in Healthy Men
For more specific prostate cancer screening, apart from prostate-specific antigen (PSA), its free fraction (fPSA) and one of its precursors, [-2]proPSA (p2PSA), are used today. From these parameters, the so-called Prostate Health Index (PHI) can be calculated. However, reference intervals for these parameters in a healthy population were not known until now.
News Antiglaucoma Eye Drops with Preservatives – Higher Likelihood of Glaucoma Surgery?
A recently published French study sought to answer the question of whether there is a connection between the presence of preservatives in antiglaucoma eye drops and the probability of undergoing glaucoma surgery.
News Compressive Therapy in Wound Treatment: Which Aids to Choose and How to Use Them Correctly?
If a patient is dealing with a chronic wound, it is necessary to support its healing with proper compressive therapy. The main goal is to reduce swelling and improve venous flow in the body.
By applying compression immediately in the morning, before any movement, we prevent blood from pooling in the lower limbs. But be careful! It must be done with the correct technique.
News Administration of aPCC as a Prevention of Bleeding After Major Cardiac Surgical Procedures
The possibility of actively preventing severe bleeding after a major cardiac surgical procedure using cardiopulmonary bypass (CPB) by administering a concentrate of activated procoagulant complex seems feasible, although a larger study will be needed to confirm its effect.
News Ocrelizumab in the treatment of multiple sclerosis in real-world practice – a systematic review of published studies
In controlled study programs, ocrelizumab has demonstrated beneficial effects on improving clinical parameters in patients with multiple sclerosis, such as the annual relapse rate or confirmed disability progression. However, to get a complete picture of its clinical benefit, real-world evidence in a broad patient population is also needed. A systematic review of real-world clinical practice studies with ocrelizumab, published in March 2023, demonstrates its benefits in patients with relapsing-remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS) in terms of relapse frequency, disease activity on MRI, disability, absence of disease activity (NEDA), and quality of life.
News Current Reimbursement Conditions for the Dual Inhibitor IL-4/IL-13 Dupilumab
The biologic dupilumab is approved for the treatment of several diseases with type 2 inflammation. What is the current reimbursement situation in key indications? We summarize in the following brief overview.
News Wound Treatment Without Pain? A Rinse Solution Can Help
Patients dealing with a healing wound may fear painful dressing changes. The wound bed is exposed and highly sensitive to pain due to damaged nerve endings. By using a rinse solution, however, we can eliminate the traumatic removal of the primary dressing, making the dressing change gentler for the patient. But which solutions are suitable for this purpose and which are not?
News Alternative to benzodiazepines or clomethiazole in the treatment of alcohol withdrawal syndrome?
Alcohol withdrawal syndrome (AWS) is a potentially life-threatening condition. A meta-analysis published in the journal Pharmacopsychiatry in September 2019 examines the effect of the combination of tiapridal and carbamazepine in the treatment of AWS. Is this combination a viable alternative to benzodiazepines or clomethiazole?
News What impact do the symptoms of primary biliary cholangitis have on the patient and their quality of life
Primary biliary cholangitis (PBC) is a serious chronic cholestatic autoimmune liver disease that predominantly affects middle-aged women and can lead to end-stage liver failure and the need for transplantation. Several studies published this year show a reduction in the quality of life of patients with this disease due to its accompanying symptoms.
News At the Crossroads: 5 Options for Alzheimer's Disease Pharmacotherapy
Currently, we have 5 basic options for the pharmacotherapy of Alzheimer's disease. Is memantine, one of the three cholinesterase inhibitors, or combination therapy the most effective? A review article by Japanese and American authors evaluates the literature on the safety and efficacy of cognitive treatments for Alzheimer's disease.
News Biocompatibility of 3D Printed Materials – Their Comparison, Legislation, and Practice
Printing three-dimensional (3D) objects brings new possibilities for producing personalized implants, prosthetics, and other medical devices in healthcare. One area where this technology can improve current practice is the printing of tracheostomy tubes for use in patients after laryngectomy. However, it is crucial to ensure the biocompatibility of the materials used for printing. In November 2023, a study comparing 3D printer materials in terms of their susceptibility to the growth of bacterial biofilms from Staphylococcus aureus was published in the journal 3D Printing in Medicine.
News Prevalence and Manifestations of Cow Milk Protein Allergy
The prevalence of food allergies is on the rise, along with the severity and variety of their manifestations. The most common food allergy in infants and toddlers is cow milk protein allergy (CMPA).
News Compression Therapy with Zinc Oxide Dressings in Dermatology
Zinc oxide dressings have a long-standing tradition and continue to find their place in modern dermatology. Compression therapy is the cornerstone of conservative treatment for chronic venous insufficiency and lymphatic insufficiency and should not be overlooked even at the stage of venous leg ulcers.