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News Current Insights into the Antispasmodic and Analgesic Effects of Metamizole on the Gastrointestinal Tract
Brazilian authors published a review of available information on the mechanism of action of metamizole, its impact on gastrointestinal tract motility, its effect on the gastric mucosa, and its antispasmodic effects.
News Asthma and Prognosis of Patients with COVID-19
The impact of asthma, its severity, and treatment on the prognosis of patients infected with the SARS-CoV-2 coronavirus was examined in an observational study published this spring.
News Role of Chemoimmunotherapy in the Era of Rapid Development of CLL Treatment Strategies and Emergence of New Drugs
In the context of the significant advancements in the field of immunotherapy and evidence of its efficacy in the treatment of chronic lymphocytic leukemia, it is pertinent to ask how this will influence therapeutic strategies in the context of first-line treatment and what the role of chemoimmunotherapy will be in the algorithms for CLL. At the 2019 NCCN Annual Congress, a panel of experts, led by Professors William G. Wierda from Texas MD Anderson Cancer Center and Jennifer R. Brown from Dana-Farber Cancer Institute, debated this topic.
News Vitamins in Prevention and Treatment of COVID-19
Vitamin supplementation is an important part of therapy for various diseases, and it seems that they also play a significant role in the case of COVID-19. What kind of role? It's certainly not a panacea, but it's not something to be underestimated.
News Calculator Naxiva - Application for Easy Prescription of Medical Cannabis Extracts
The new Calculator Naxiva application, specifically designed for doctors prescribing medical cannabis, allows for a simple conversion of its doses to the Naxiva Panaxol extract. Quickly and easily, the required amount of extract for a particular patient can be calculated.
News Interchangeability of Diosmin and Micronized Purified Flavonoid Fraction
Among the medicinal products reimbursed for chronic venous disease, those containing micronized diosmin (Diozen 180 tbl.) have been newly included. Which substances are available for this indication, and what determined the interchangeability of micronized diosmin with micronized purified flavonoid fraction (MPFF) and other selected venotonics stabilizing capillaries?
News Practical Experiences Using ZULP in Cardiology
The application of a product containing ferric carboxymaltose (FCM) or the use of a contrast agent with sulfur hexafluoride in microbubbles are examples of the use of specially accounted medicinal products (ZULP) in cardiology practice. "A benefit for the patient is that they receive the indicated preparation directly in the office and do not have to procure it themselves from a pharmacy," says Dr. Jiří Veselý, head physician of the Edumed cardiology clinic in Jaroměř, with whom we discussed the advantages and disadvantages of using ZULP and his experiences with this system.
News Long-Term Effect of Nuclear Magnetic Resonance Therapy on Osteoarthritis – An Unconventional Case Report
Osteoarthritis is among the most common health issues in adults, with its prevalence increasing with advancing age. There is currently no causal therapy for the disease; hence, the standard approach is symptomatic treatment with surgical joint reconstruction in advanced stages of the disease. The presented case report describes a successful case of long-term therapy for osteoarthritis using molecular biophysical stimulation.
News Neuroprotective Efficacy and Safety of Vinpocetine in Patients with Acute Ischemic Stroke
A meta-analysis of 4 randomized placebo-controlled studies demonstrated the benefits of vinpocetine in patients with ischemic stroke (iCMP). Administering vinpocetine within 14 days of the onset of the stroke significantly reduced the level of disability and the proportion of those who died or were dependent on others after 1 and 3 months. The results showed benefits in several other parameters and indicated very good tolerability of this drug used to increase cerebral blood flow.
News Does the type of oral anticoagulant affect heparin dosing during catheter ablation?
During catheter ablation, which patients undergo as part of atrial fibrillation (AF) treatment, current guidelines recommend the administration of heparin without interrupting oral anticoagulant therapy. A recently published analysis evaluated whether the type of oral anticoagulant affects the total dose of heparin administered during the ablation.
News Current Therapy Options for Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis is a chronic progressive disease that exclusively affects adults, predominantly of middle and older age. Until recently, the disease was practically untreatable. However, this has changed with the discovery of antifibrotic drugs, which have significantly altered the prognosis for patients. Early diagnosis and initiation of therapy at a specialized center, of which there are several in the Czech Republic, are essential for success.
News Long-term Safety and Efficacy of Ozanimod in the Treatment of Relapsing Forms of MS
Ozanimod is classified as a modulator of sphingosine-1-phosphate (S1P) receptors types 1 and 5. It is approved for the treatment of relapsing-remitting multiple sclerosis (RRMS) and moderate to severe ulcerative colitis (UC) and continues to undergo intensive clinical research. The DAYBREAK open-label, single-arm study for participants with RRMS from previous trials with ozanimod was scheduled to be completed by January 2023, and its final results can therefore be expected soon. The following article presents the interim analysis results of this study 5 years after initiation.
News Pathogenetic Mechanisms Underlying the Development and Progression of Interstitial Lung Diseases
Interstitial lung processes (ILP) represent an umbrella term for a wide range of nosological units that differ from each other in clinical course, prognosis, and pathogenesis. Most ILPs are characterized by inflammation or fibrosis of the interstitial space, leading to impaired gas exchange at the alveolocapillary membrane.
News Current Recommendations of the International League Against Epilepsy for the Treatment of Seizures in Newborns
In 2023, a team of experts in neurology, neonatology, and pediatrics, along with representatives of parents, published recommendations for the treatment of epileptic seizures in newborns. These were developed based on a systematic literature review (and in cases of insufficient evidence, based on consensus achieved using the Delphi method) and include first and second choice pharmacotherapy, dosing, duration of treatment, effects of therapeutic hypothermia, and the use of pyridoxine. We offer their summary in a nutshell (and always indicate the strength of the recommendation in parentheses).
News Bite-Sized Pieces from EHA 2021: Two New Findings on T-Cell Lymphoma
Can a molecule that is crucial for the sensitivity of adult T-cell lymphoma or leukemia (ATLL) to NK cell cytotoxicity be identified? And what conclusions were drawn from the testing of an antibody specific for TRBC1 in the investigation of T-lymphoproliferative disorders? These topics were also covered at the EHA 2021 congress, in the electronic poster presentation section.
News Beta-blockers in the treatment of chronic heart failure: How did the analysis of the effects of 4 drugs in 26 studies turn out?
As a cornerstone of therapy for chronic heart failure with reduced ejection fraction (HFrEF), it is recommended to start treatment with a very low dose of beta-blockers (BB) and titrate it to the maximum tolerated dose. However, it remains unclear whether one BB is superior to others. For this reason, a comprehensive pooled analysis of the efficacy and safety of bisoprolol, carvedilol, nebivolol, and metoprolol in 26 studies, including 14 randomized controlled and 12 observational, was recently published.
News Diagnosis of AAT Deficiency According to Italian Recommendations and a Clear Algorithm for Practice
Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that primarily affects the lungs and liver. It is considered a rare disease, but it is also significantly underdiagnosed. Given the availability of specific treatment, which involves the administration of purified alpha-1 antitrypsin (AAT) derived from human plasma in patients with COPD due to AATD, identifying these patients is crucial. We summarize the recently issued Italian recommendations for the diagnosis of AATD and place them in the context of Czech standards.
News Venotonics in Hemorrhoid Therapy – Results of a Systematic Review
Hemorrhoids are among the most common pathological findings in the anorectal area, and their incidence increases with age. Various modalities are used in the treatment of this condition, which has unpleasant health and psychological complications, aiming to alleviate the symptoms. Widely used and very popular are so-called venotonics, a large group of drugs and dietary supplements, mostly of natural origin, including diosmin.
News Lung Recovery After COVID-19: How Reversible is the Damage?
During the virtual XXV Hradec Pulmonology Days held in April 2021, various aspects concerning COVID-19 were among the major topics. Dr. Bram van den Borst from Radboud University Nijmegen provided a comprehensive summary of current insights regarding lung recovery following an infection.
News Comparison of Cardiovascular Effects of Sitagliptin and Empagliflozin
Cardiovascular (CV) diseases remain the leading cause of death among patients with type 2 diabetes (T2D). Reducing the incidence of macrovascular CV events in diabetics requires more than just glycemic control alongside all other present CV risk factors. New antidiabetic drugs represent a very promising group of medications with a favorable safety profile, aiding in reducing the risk of CV complications.
News Electronic Cigarettes as an Alternative Option for Quitting Smoking?
Diseases caused by smoking tobacco products are a significant cause of global morbidity and mortality. One of the options for quitting smoking is electronic cigarettes, which, although not entirely researched yet, according to available studies, genuinely help people quit smoking and are associated with significantly lower health risks compared to traditional tobacco products.
News How Do Patients Themselves Perceive Today's Treatment Options for ITP and What Are Their Biggest Fears?
What is the perception and view of the treatment options for immune thrombocytopenia (ITP) from the patients' perspective, what do they fear, what approaches do they prefer, and why? Lozano et al. included a discussion on this topic in their review article for Expert Review of Hematology, which can be helpful in clinical practice for better understanding patients' needs and adjusting treatment algorithms.
News Fatigue in Multiple Sclerosis: What Can Teriflunomide Do?
An article by French authors published in January this year in the journal Multiple Sclerosis and Related Disorders evaluated the effect of teriflunomide on fatigue in patients with multiple sclerosis in real-world practice.
News Lung screening in the Czech Republic has detected over a hundred cases of lung cancer
The purpose of lung screening, which has been ongoing in the Czech Republic since January 2022, is to detect early stages of lung cancer and increase awareness of this malignant disease in relation to smoking. Data analysis from health insurance companies through the National Registry of Paid Health Services (NRHZS) revealed that out of nearly 4,000 individuals who underwent low-dose CT as part of the screening examination, 116 were diagnosed with cancer.
News Teriflunomide and Pregnancy Planning
The authors of the article published last year in Multiple Sclerosis Journal present data regarding experiences with the use of teriflunomide during pregnancy.