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News Combined Hormonal Contraception in the Treatment of Dysmenorrhea
Dysmenorrhea troubles many women of reproductive age and can deteriorate their quality of life, making it important for doctors to offer suitable therapy. We summarize the findings of research on the use of hormonal contraception containing drospirenone (DRSP) and ethinylestradiol (EE) in the treatment of dysmenorrhea.
News Ketogenic diet in MS patients as an aid to increase microbiota diversity and quantity
A recent study published in the journal Frontiers in Microbiology explores the role of gut microbiota in multiple sclerosis, specifically the changes in its quantity and the potential for influencing microbiota through a ketogenic diet.
News Cannabidiol as a way to reduce anxiety in patients with Parkinson's disease?
A recent study by Brazilian authors examined the effects of cannabidiol on tremors and anxiety in patients with Parkinson's disease. Could it represent a promising modality in this indication?
News Current Treatment Options for Refractory/Relapsed CLL
How have treatment protocols for chronic lymphocytic leukemia changed in recent years? A review published in Acta Haematologica discusses the current therapeutic options for relapsed or refractory disease.
News The Importance of Adequate Protein Intake in Critical Patients – Analysis of Data from an International Study
Adequate protein intake is a necessary part of care for critically ill patients and mitigates catabolic reactions associated with severe illness or injury. The benefits of proper determination and adherence to protein intake, however, have not been sufficiently assessed in detail. Therefore, this topic was the focus of a work analyzing data from an international observational multicenter study published in the Journal of Parenteral and Enteral Nutrition.
News When to Switch to Second-Line Treatment for Primary Biliary Cholangitis?
In patients with primary biliary cholangitis (PBC), the response to ursodeoxycholic acid (UDCA) treatment is an important prognostic indicator. To identify patients with an insufficient response to this modality who require second-line therapy, the best practice is to assess the biochemical response to UDCA after 12 months of treatment. A validated and easy-to-use tool is the determination of serum alkaline phosphatase (ALP) activity and serum total bilirubin concentration. Although treatment response to UDCA is commonly checked after 12 months, a 6-month check has the same discriminatory value.
News Dosing of Enoxaparin in Morbidly Obese Patients
How to optimally dose enoxaparin in morbidly obese patients? This question was addressed by a randomized study, the results of which were published in the journal Annals of Pharmacotherapy.
News Interactive Case Study: Use of Cannabis Extract for Local Treatment of Neuropathic Pain
We have been using cannabis for pain treatment for several years. We also have good experiences with it in difficult-to-control symptoms of neuropathic pain, as illustrated in the following case study. Until recently, our patients only used cannabis orally or via vaporization. With the availability of cannabis extracts, a new option has emerged – local therapy.
News Postpartum Uterine Artery Pseudoaneurysm in a Woman with vWD – Case Study
Women with von Willebrand disease (vWD) have a significantly higher risk of postpartum hemorrhage. American experts from University Hospital in Augusta have published their experience with an unusual case of secondary postpartum hemorrhage in a young woman with type 1 vWD.
News Estimated Worldwide Prevalence of Population with AAT Deficiency with MZ Alleles
Alpha-1-antitrypsin deficiency (AATD) with the MZ genotype was until recently associated with negligible or low risk for lung and liver tissue damage. However, growing evidence suggests that carriers of MZ alleles are at increased risk of organ damage when exposed to tobacco smoke, polluted air, or hepatotoxic substances. Moreover, according to a global epidemiological study, the prevalence of the MZ genotype is very common, especially among Caucasians in Europe and other continents.
News The Latest Updates of ESC Recommendations for Heart Failure Treatment
What is new in heart failure therapy? At the annual congress of the European Society of Cardiology (ESC), held from August 25–28, 2023 in Amsterdam, updates to clinical guidelines were traditionally presented. One of these was an update to the 2021 recommendations concerning the diagnosis and treatment of acute and chronic heart failure (HF). Below you will find a brief summary of the key changes.
News Pain Management in Patients After Hip and Knee Arthroplasty – Data from Clinical Practice
Inadequate analgesia after hip and knee arthroplasty can result in delayed postoperative recovery accompanied by chronic pain. The retrospective study presented below compared the efficacy of analgesia via continuous epidural infusion of ropivacaine, patient-controlled IV analgesia with the so-called Würzburg drip, and piritramide.
News Metabolic Effect of Telmisartan and Candesartan in Kidney Transplant Patients
Increasing cardiovascular risk from complex causes warrants a comprehensive intervention. A prospective randomized crossover study compared the effects of telmisartan and candesartan on lipid and glucose metabolism in kidney transplant patients.
News Enoxaparin in the Treatment of Pulmonary Embolism in a Morbidly Obese Patient – Case Report
The number of patients suffering from overweight and obesity has been steadily increasing in recent years. Obesity is one of the independent risk factors for thromboembolic disease. Treating thrombotic complications in obese patients poses a challenge not only because of the adjustments in anticoagulant dosing but also due to the lack of evidence regarding the safety and efficacy of higher doses of anticoagulants in this growing group of the population.
News Sports in People with Hemophilia – Possible and Safe
Active involvement in sports and an active lifestyle are important aspects of daily functioning for people with hemophilia. Modern treatment of this disease, including the prophylactic administration of concentrates of the missing coagulation factor, has led to an increase in the number of very active patients. Numerous studies have confirmed that they are as physically active as the general population, although some emphasize that this is more relevant to children and young people. Therefore, the work of Dutch and Swedish authors focused on examining the relationship between age and physical activity in hemophiliacs, especially with regard to more intensive and riskier sports.
News Postoperative Bleeding in Children with Hypofibrinogenemia Induced by Cardiopulmonary Bypass
Patients undergoing cardiac surgery with the use of cardiopulmonary bypass are at risk of up to a 40% reduction in plasma fibrinogen levels, with subsequent risk of perioperative bleeding. Children undergoing surgery for congenital heart defects are even more sensitive to the reduction in fibrinogen. What are the possible solutions, and is any one of them significantly better?
News Diosmin Succeeded in Preventing Ovarian Hyperstimulation Syndrome in Study
In a recently published study, diosmin was evaluated in women undergoing in vitro fertilization (IVF). Attention was focused on its effect in preventing and treating ovarian hyperstimulation syndrome (OHSS).
News Current Recommendations of the Expert Panel on the Management of von Willebrand Disease
Von Willebrand disease (vWD) is a common congenital bleeding disorder. The care of patients with vWD involves significant variability due to bleeding manifestations and treatment options. The new recommendations from 2021 regarding the care of people with vWD are evidence-based and supported by the American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), the National Hemophilia Foundation USA (NHF), and the World Federation of Hemophilia (WFH). We bring you a concise summary of the key points.
News Current Findings on Fixed Combination Aclidinium/Formoterol in COPD Therapy
The fixed inhalation combination of aclidinium/formoterol represents a combination of a long-acting anticholinergic (LAMA) and a long-acting β2-mimetic (LABA) used for maintenance treatment of moderate to severe chronic obstructive pulmonary disease (COPD). Below, we summarize the current findings on the efficacy and safety of this dual bronchodilation therapy.
News Current NCCN Recommendations for Classification and Risk Symptoms in SLL/CLL
The new recommendations from the National Comprehensive Cancer Network (NCCN) regarding chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) from August 2022 also include a brief summary of the most common symptoms and methods for classifying the disease based on its extent at diagnosis or in case of progression.
News Benefits of Time-Limited CLL Therapy
The advent of new targeted molecules has significantly influenced the possibilities of therapy for chronic lymphocytic leukemia (CLL) and are now an integral part of treatment regimens, including the 1st line. Individual therapeutic approaches and strategies based on them have their advantages and disadvantages as well as their target patient group, but the concept of time-limited treatment is increasingly gaining ground. Therapy today is significantly individualized, and its optimal choice is based on the assessment of various circumstances on the patient’s part and their disease.
News Sonicare Technology as a Modern Means for Good Oral Hygiene
Sonicare technology was developed and introduced to the market by Philips 30 years ago. Since then, the range of products has expanded, and the use of sonic technology has become accessible to a wide spectrum of patients with various problems and needs.
News Psychotic patient with high cardiometabolic risk – interactive case report
The following case report describes the treatment of a patient diagnosed with paranoid schizophrenia following a relapse of the disease. During therapy, complications arose in the form of weight gain, deterioration of metabolic parameters, sedation, and sexual dysfunction. Additionally, the patient is not capable of adhering to the principles of a healthy lifestyle. Is it possible to find an optimal treatment approach even in such a case?