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News Options for Preventing Enteral Nutrition Intolerance in Mechanically Ventilated Patients in the ICU
Standards of care for critically ill patients recommend enteral nutrition for those on mechanical ventilation. A recently published study addressed the question of how to identify patients at risk of enteral nutrition intolerance (ENI) and how to subsequently prevent this intolerance, which may be associated with worse clinical outcomes.
News Consensus on the Administration of TPO-RA as Second-Line Therapy in ITP
What is the role of thrombopoietin receptor agonists (TPO-RA) in the second line treatment of patients with immune thrombocytopenia (ITP)? Italian authors conducted a survey using the Delphi method among selected experts to gather answers to this question and recommendations for clinical practice. Here, we briefly summarize the key points of their consensus published last year.
News Use of Enoxaparin in Patients After Implantation of Left Ventricular Assist Device
Left ventricular assist devices (LVAD) are utilized in patients with end-stage heart failure (HF). Warfarin is typically employed for long-term anticoagulation, but there are no standardized recommendations for anticoagulant therapy during the postoperative period. One option to bridge the time until therapeutic INR is achieved after LVAD implantation is the low molecular weight heparin (LMWH) enoxaparin, which was investigated for its efficacy and safety in this indication by experts from Kansas, USA, cited in the following study.
News New Solution for Moderate Incontinence – Discreet Pull-Up Diaper Pants
The range of products for people with incontinence is constantly expanding – recent additions include pull-up diaper pants labeled Seni Active Basic and Seni Active Classic.
News Safety and Tolerability of Bilastine in the Treatment of Chronic Urticaria in Children
Chronic urticaria is less common in pediatric patients compared to the acute form, but it always requires therapy due to bothersome chronic symptoms that reduce quality of life and disrupt daily activities of affected children. According to recent guidelines, the first-line treatment is non-sedating second-generation antihistamines, among which bilastine is included.
News Efficacy of L. reuteri DSM 17938 in Treating Acute Gastroenteritis in Children
Diarrheal diseases are among the most common causes of death worldwide in children under 5 years of age. Effective and timely treatment is crucial in the case of acute gastroenteritis (AGE), which is why probiotics are attracting significant attention in the context of AGE therapy. A meta-analysis published last year in the journal Nutrients focused on the efficacy of Lactobacillus reuteri DSM 17938 in treating AGE in children from 3 months to 5 years old.
News Nutritional Care as Part of Prehabilitation in Surgical Patients
Nutritional preparation of patients before surgery as part of prehabilitation can significantly affect the quality of recovery and physical condition of patients after surgery. This topic is highlighted, among other sources, by a team of Canadian doctors in their work published in the journal Anesthesiology, an interesting meta-analysis of 15 RCTs, and last but not least, it is covered in a webinar titled 'Surgical Patient and Nutrition'.
News Romiplostim in a Pregnant Woman − Case Report
The following clinical case demonstrates good control of resistant immune thrombocytopenia in a pregnant woman during the administration of romiplostim.
News Diosmin – Still an Important Modality in the Treatment of Venous Insufficiency
Chronic venous insufficiency is a highly prevalent disease in the Western population. Unfortunately, it remains without causal treatment. In the recommended therapeutic procedures, especially in the initial stages, compression treatment supplemented with pharmacotherapy plays a key role. This includes the administration of medicinal products containing micronized diosmin. The following text summarizes basic findings about its properties that predispose it to clinical use.
News ICIS Report: Potential of TPO-RA as Early Immunomodulatory Treatment of Immune Thrombocytopenia
The report from the meeting of the Intercontinental Cooperative ITP Study Group (ICIS) in 2022 in Lenzerheide, Switzerland, published late last year in the British Journal of Haematology, discusses the potential of early treatment of immune thrombocytopenia with thrombopoietin receptor agonists (TPO-RA) in achieving a disease remission sustainable without further therapy.
News Effect of Administering Ferric Carboxymaltose on Quality of Life in Heart Failure Patients
The quality of life in patients with heart failure is significantly reduced. The concurrent occurrence of iron deficiency further exacerbates this situation. The AFFIRM-AHF study evaluated the impact of intravenous administration of ferric carboxymaltose on health-related quality of life (HRQoL) in patients with heart failure who also suffered from iron deficiency.
News Minimum and Optimal Factor Levels in Physically Active Hemophiliacs
Authors of a recently published study attempted to determine the value of minimum and optimal levels of coagulation factors in patients with severe hemophilia who engage in physical activities.
News Options for Tapering TPO-RA in ITP Patients: Practical Experience and Expert Consensus
A recently published British study aims to provide recommendations on tapering TPO-RA in patients with immune thrombocytopenia (ITP) based on existing evidence, survey results of clinical practice among hematologists, and expert consensus.
News Comparison of the Effectiveness of Different Types of Toothbrushes in Orthodontic Patients
The aim of the study cited below was to evaluate the efficiency of a manual orthodontic brush, an electric toothbrush with an oscillating head, and a sonic toothbrush in controlling plaque, gingivitis, and interproximal bleeding in patients undergoing orthodontic treatment with fixed appliances and to compare their relative effectiveness.
News How do patients perceive the change in appearance of chronically used medications and to what extent does it lead to non-adherence to therapy?
Doctors regularly encounter patients in their offices who complain about changes in the appearance of their chronically used medications. Such a change can even be the cause of non-adherence to treatment. Interesting findings on this topic were brought by an American survey aimed at identifying the preferences, experiences, and reactions of patients and pharmacists related to changes in the appearance of medications.
News High Dose of Protein Affects Mortality in Critically Ill Patients if They Do Not Have Sepsis
The optimal composition of nutrition in terms of adequate energy and protein intake for critically ill patients is still a subject of professional discussion. The study cited below aimed to shed more light on this issue by evaluating how early intake of high amounts of proteins and excessive energy intake affects mortality in these patients.
News EMPATHY Questionnaire as a Tool for Better Personalization of Levothyroxine Doses in Patients with Primary Hypothyroidism?
The therapy for hypothyroidism consists of substitution with levothyroxine (L-T4). Failure to achieve the target thyrotropin hormone (TSH) level can be due to non-compliance (in 60% of cases) or malabsorption of the drug (in 40%). The aim of the presented Italian study was the validation of the EMPATHY questionnaire for better personalization of therapy.
News Summary of New American Recommendations for Heart Failure Management
This year, the American Heart Association (AHA), the American College of Cardiology (ACC), and the Heart Failure Society of America (HFSA) released joint recommendations for the diagnosis and treatment of heart failure in clinical practice. These new guidelines replace the previous recommendations from 2013 and their 2017 update. We summarize the 10 key points to remember as outlined by the authors of the new guidelines and focus on the treatment of the subgroup of patients with heart failure with preserved ejection fraction (HFpEF).
News Idiopathic Thrombocytopenic Purpura with SARS-CoV-2 Infection
To date, 45 cases of idiopathic (autoimmune) thrombocytopenic purpura (ITP) in individuals with confirmed SARS-CoV-2 infection have been published in the literature. In September 2020, a review summarizing the clinical profile and treatment outcomes of ITP in these individuals was released.
News Compression therapy in combination with surgical intervention in the treatment of venous leg ulcers and prevention of their recurrence
Compression therapy represents an important part of the treatment of venous leg ulcers; it also plays a role in preventing possible recurrences. The 4-year British ESCHAR study evaluated the impact of combining compression therapy with surgical correction of reflux in the superficial venous system on the healing and potential recurrence of venous leg ulcers compared to compression therapy alone.
News Neutralizing Antibodies Against Emicizumab – Detailed Analysis Based on a Case Study
Japanese authors investigated the mechanism of reduced efficacy of emicizumab in an adult patient with hemophilia A and an inhibitor, whose treatment was discontinued due to repeated bleeding episodes with prolonged aPTT.