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News Clinical Characteristics of Trauma Patients Requiring Dosing Adjustments of Enoxaparin in TEN Prevention

Injuries and trauma surgical procedures represent a significant risk factor for the development of thromboembolic disease (TEN). Routine thromboprophylaxis is thus recommended for trauma patients, often in the form of low molecular weight heparins (LMWH), including enoxaparin. A recently published study evaluated factors associated with the need for higher dosing of enoxaparin to achieve effective prophylactic levels.

Source: Thromboprophylaxis 4. 11. 2021

News Is It Better to Switch or Cycle in the Treatment of Rheumatoid Arthritis?

The ideal strategy for treating rheumatoid arthritis is still the subject of research. We therefore present the results of a recent study comparing the impact of various therapeutic options when biological treatment is ineffective.

Source: Arthritis 24. 9. 2020

News EAHAD 2024: Fresh results of paradigm5 and 6 studies confirm safety and efficacy of N9-GP

Nonacog beta pegol (N9-GP) is a recombinant factor IX with an extended half-life. Its properties allow for the maintenance of a satisfactorily high level of FIX with intravenous application once a week. At the 17th Annual Congress of the European Association for Haemophilia and Allied Disorders (EAHAD), held in early February 2024 in Frankfurt, new findings on this treatment were presented during a satellite symposium by Novo Nordisk.

Source: Hemophilia with Movement 30. 4. 2024

Články časopisu Regulatory network of competitively interacting RNAs and effectiveness of rectal tumors radiotherapy

Author of the article: D. S. Kutilin, M. A. Gusareva, N. G. Kosheleva, O. I. Kit Source: Klinická onkologie | 4/2022 17. 8. 2022

News Options for Modifying and Improving the Efficiency of the HJHS Scoring System

The Hemophilia Joint Health Score (HJHS) is a validated tool for assessing joint health in individuals with hemophilia. Can it be modified to be used more effectively in clinical practice?

Source: Hemophilia with Movement 30. 11. 2020

News Does the type of oral anticoagulant affect heparin dosing during catheter ablation?

During catheter ablation, which patients undergo as part of atrial fibrillation (AF) treatment, current guidelines recommend the administration of heparin without interrupting oral anticoagulant therapy. A recently published analysis evaluated whether the type of oral anticoagulant affects the total dose of heparin administered during the ablation.

Source: Anticoagulant Treatment 22. 3. 2021

News 6-year data from the ECHELON-1 study: How does combining brentuximab vedotin with chemotherapy affect overall survival of previously untreated cHL patients?

At this year's annual congress of the European Hematology Association (EHA), results from the analysis of 6-year data from the international randomized open-label phase III ECHELON-1 study on overall survival of patients with classical Hodgkin lymphoma (cHL) stage III/IV who received a combination of brentuximab vedotin with chemotherapy in the first-line treatment were presented, among other findings.

Source: Hematologic Malignancies 10. 8. 2022

News Practical Two-Point Pharmacokinetic Protocol in Hemophilia A

A recently published study confirmed the practicality of a shortened and simple pharmacokinetic protocol for patients with hemophilia A.

Source: Hemophilia 31. 1. 2022

News Monocyte Distribution Width as an Early Indicator of Sepsis in ICU Patients

Authors of a Franco-Spanish study propose using the monocyte distribution width along with leukocyte count as a screening test to refine the early diagnosis of sepsis in intensive care unit (ICU) patients based on their research findings.

Source: Because 9. 4. 2022

News Incidence and Risk Factors of Community-Acquired Pneumonia in Hematologic Oncologic Patients

Patients with hematologic malignancies are at higher risk of infectious diseases, particularly community-acquired pneumonia, due to immunosuppression. However, recent data providing information on the incidence and risk factors of community-acquired pneumonia in this patient group are quite limited. The aim of the cohort study published by Dutch authors was therefore to supplement the missing recent information on the issue of community-acquired pneumonia in hematologic oncologic patients.

Source: Anti-Infectives 5. 7. 2022

News Post-COVID-19 Patient Care from the Perspective of Experts Across Fields

For many patients with COVID-19, overcoming the acute phase is crucial, but we now know that the disease may not end there. Some patients even manage the acute stage with very mild symptoms, and significant difficulties arise later in the form of 'post-COVID syndrome.' This issue was discussed in detail at a January webinar by leading experts from various fields.

Source: Cough Therapy 19. 3. 2021

News Diosmin Succeeded in Preventing Ovarian Hyperstimulation Syndrome in Study

In a recently published study, diosmin was evaluated in women undergoing in vitro fertilization (IVF). Attention was focused on its effect in preventing and treating ovarian hyperstimulation syndrome (OHSS).

Source: Venous Insufficiency 28. 5. 2020

News Efficacy of Bruton Tyrosine Kinase Inhibitors After Venetoclax Therapy in Patients with CLL

Targeted therapy has changed the treatment approach for chronic lymphocytic leukemia (CLL), showing higher efficacy and safety compared to standard chemoimmunotherapy. Until recently, an important question remained unanswered: whether the administration of Bruton tyrosine kinase inhibitors (BTKi) after previous therapy with the BCL-2 inhibitor venetoclax provides sufficient clinical effect.

Source: Chronic Lymphocytic Leukemia 11. 12. 2020

News EHL preparations have the potential to change the quality of life for people with hemophilia

Within the therapeutic modalities for hemophilia, the current era offers a number of preparations. Newer extended half-life (EHL) replacement therapies can provide hemophiliacs with better protection against bleeding and allow for greater physical activity.

Source: Hemophilia with Movement 27. 10. 2020

News Current Recommendations of the Expert Panel on the Management of von Willebrand Disease

Von Willebrand disease (vWD) is a common congenital bleeding disorder. The care of patients with vWD involves significant variability due to bleeding manifestations and treatment options. The new recommendations from 2021 regarding the care of people with vWD are evidence-based and supported by the American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), the National Hemophilia Foundation USA (NHF), and the World Federation of Hemophilia (WFH). We bring you a concise summary of the key points.

Source: Von Willebrand Disease 4. 1. 2022