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News Incontinence Dermatitis -⁠ Common, Yet Often Overlooked Diagnosis

Incontinence dermatitis is an inflammatory skin reaction with a prevalence between 3 and 25%, caused by prolonged skin contact with urine or feces. It is classified among contact irritant dermatitis. It causes significant discomfort to patients and can also require difficult and prolonged treatment.

Source: Incontinence 21. 4. 2020

News Empagliflozin Secures Reimbursement for Heart Failure Treatment

Starting May 1st, health insurance companies will cover Jardiance^® (empagliflozin) for patients with heart failure with reduced ejection fraction. Cardiologists, pediatric cardiologists, angiologists, and internists will be able to prescribe it with reimbursement. This decision was made by the State Institute for Drug Control (SÚKL) in mid-April. Hundreds of thousands of Czechs suffering from this serious condition will now have access to another effective medication. The drug is manufactured by Boehringer Ingelheim.

Source: Heart Failure 3. 5. 2022

News Trazodone as an Effective Medicine in the Therapy of Depression and Insomnia

Trazodone (Trittico®) is a medicine indicated for the treatment of depression, which has also been shown to have a positive effect in treating other associated conditions. In practice, however, the potential of its multimodal effect sometimes remains untapped.

Source: Depression and Anxiety 19. 7. 2020

News Alopecia Areata –⁠ Autoimmune Inflammatory Disease and a New Targeted Treatment Option

Alopecia areata (AA) is one of the non-scarring focal alopecias. It is an autoimmune disease of the hair follicle, the etiopathogenesis of which is not entirely understood. At the hair root, a lymphocytic inflammatory infiltrate develops, resulting in follicle miniaturization and the growth of a thin dystrophic hair. Recently, however, a new strategy for the treatment of AA has emerged, focusing on reducing inflammation of the hair follicle by inhibiting Janus kinases (JAK). This is the first therapeutic modality officially approved for this indication.

Source: Biological Treatment 31. 10. 2022

Články časopisu Type 1 and 2 diabetes and pregnancy

Author of the article: L. Féderová, M. Korbeľ, Z. Nižňanská Source: Praktická gynekologie | 2/2010 23. 7. 2010

Články časopisu ALTERNATIVE PROCEDURE FOR COMPLETE DENTURE FABRICATION

Author of the article: R. Mounajjed, M. Přibyl Source: Česká stomatologie / Praktické zubní lékařství | 2/2019 24. 6. 2019

Články časopisu Guidelines of the Czech Society of Hepatology for diagnosis and treatment of primary biliary cholangitis

Author of the article: T. Fejfar, T. Vaňásek, P. Hůlek, L. Vítek, S. Fraňková, R. Brůha Source: Gastroenterologie a hepatologie | 2/2018 4. 5. 2018

News Efficacy and Safety of Dual Bronchodilator Therapy for COPD –⁠ From Randomized Clinical Trials to Real-World Clinical Practice

Dual bronchodilator therapy (LAMA + LABA) represents one of the mainstays of treating chronic obstructive pulmonary disease (COPD). The aim of the recent systematic review presented below was to assess the efficacy and safety of this dual therapy compared to monotherapy or other combinations in the context of clinical trials and real-world clinical practice.

Source: Treatment of Asthma and COPD 18. 11. 2021

News Diagnosis of Cow Milk Protein Allergy −⁠ Current Methods and Their Diagnostic Value

Cow milk protein allergy (CMPA) is among the most common pediatric food allergies. In case of early reaction, the child should be immediately referred to an allergist; for delayed symptoms, an elimination-exposure test can be performed under the guidance of a pediatrician.

Source: GI, colic and microbiome 15. 2. 2023

News The Wound Healing Process Step by Step and What Can Complicate It

Proper care of injuries is a fundamental prerequisite for their successful healing. Knowing the individual phases of healing facilitates treatment and helps prevent the most common complications.

Source: Wound Healing 2. 12. 2020

Články časopisu Treatment of liver cirrhosis –⁠ actually possibility of ambulant internist

Author of the article: Jiří Ehrmann, Květa Aiglová, Michal Konečný, Vlastimil Procházka, Drahomíra Vrzalová Source: Vnitřní lékařství | 7-8/2016 6. 9. 2016

News State of the Intestinal Microbiome and COVID-19 Infection −⁠ Possible Correlations

Some patients infected with the SARS-CoV-2 virus exhibit gastrointestinal symptoms, including diarrhea, during the course of COVID-19. Current knowledge suggests that COVID-19 symptoms are related, among other things, to the intestinal microbiome. Could the use of probiotics therefore act as a prevention of this disease or its more severe course?

Source: GI, colic and microbiome 16. 2. 2021

News Diagnosis and Management of Therapy for a Breastfeeding Patient with Significant Elevation of Liver Enzymes Postpartum –⁠ Interactive Case Study

In the following case study, we present a specific approach to a patient who developed a significant elevation of liver enzymes after childbirth. Through interactive elements, you can try out how you would proceed in diagnosing and treating this case.

Source: Primary Biliary Cholangitis 14. 4. 2023

News Prof. Hana Rosolová: According to recent studies, caution is needed with beta-blockers only in severe cases of asthma and COPD

Beta-blockers (BB) are among the most widely used drug groups in cardiology. While their position is clear in some indications, it is debated in others. Additionally, individual BBs differ in various aspects, which plays an important role in selecting the right treatment for a particular patient. We discussed some current topics related to beta-blockers with the head physician of the Center for Preventive Cardiology of the 2nd Department of Internal Medicine LF UK and FN Plzeň Prof. MUDr. Hana Rosolová, DrSc., FESC.

Source: Cardiovascular Continuum 23. 11. 2023

News Memantine in Dementia Therapy –⁠ Current Findings and Possible Future Applications

Memantine is an inhibitor of NMDA receptors, which are pathologically activated by excessive concentrations of glutamate in the synaptic cleft in Alzheimer's disease. It is indicated in the treatment of moderate to severe cases of Alzheimer's disease, often in combination with acetylcholinesterase inhibitors. At the experimental level, its administration shows a number of promising effects, including an impact on diabetes associated with the development of neurodegenerative diseases.

Source: Cognitive in the treatment of Alzheimer's disease 26. 1. 2022