Search

News American Heart Association: Side Effects of Statins Overview and Context

The American Heart Association (AHA) report provides an updated summary of knowledge on the safety of statin use. Despite warnings appearing in professional literature and general media, it assures that statins are an effective and safe modality for treating hypercholesterolemia.

Source: Cardiovascular Risks 15. 4. 2020

News Anabolic Antiosteoporotic Treatment as a First Step in Patients with Very High Fracture Risk

According to the 2022 opinion of the ESCEO (European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases) working group, it is advisable to identify patients with osteoporosis who have a very high risk of fracture and to use an anabolic antiosteoporotic drug as the initial pharmacotherapeutic intervention, followed by necessary antiresorptive treatment to be addressed over the entire expected length of life.

Source: Osteoporosis – Trends in Sequential Therapy 18. 1. 2024

News Depakine Chrono versus Other Valproates in the Treatment of Bipolar Disorder

Bipolar disorder is among the most severe psychiatric illnesses, and if not treated properly, it can negatively affect the patient's quality of life. Does switching therapy from other valproates to Depakine Chrono lead to better outcomes in treating this disease? The following study aimed to find the answer to this question.

Source: Bipolar Disorder 18. 11. 2020

News Augmentation of Clozapine with Lurasidone in Resistant Schizophrenia in Real Practice

Treatment-resistant schizophrenia remains a clinical and pharmacological challenge. Clozapine remains the gold standard in these cases. Unfortunately, a significant portion of patients respond only partially to it. The solution is often an augmentation strategy with another atypical antipsychotic. According to current findings, adjunctive therapy with lurasidone appears promising —⁠ two recently published studies have brought interesting data.

Source: Modern Treatment of Schizophrenia 12. 12. 2023

Články časopisu Small cell lung cancer –⁠ news in the tumour´s biology

Author of the article: Klára Pavlíčková, Radoslav Matěj Source: Česko-slovenská patologie | 1/2023 18. 4. 2023

News Can We Lump All Gabapentinoids Together?

General practitioners often encounter peripheral neuropathic pain in their practice. One of the primary modalities for treating both painful diabetic neuropathy and postherpetic neuralgia is gabapentinoids, specifically gabapentin and pregabalin. Are these substances completely interchangeable, or do their efficacy and practical application differ?

Source: Neuropathic Pain 18. 2. 2020

News Carpal Tunnel Syndrome as a Warning Sign of Cardiomyopathy Caused by Transthyretin Amyloidosis

Recent study results suggest that transthyretin amyloidosis is a more common cause of heart failure than previously thought. Early diagnosis and subsequent therapy are key to improving patient prognosis. A comprehensive study evaluating data from the Danish population registry suggests that carpal tunnel syndrome may be one of the initial symptoms of the disease.

Source: Amyloidosis 2. 3. 2023

News Therapy of Chronic Leg Ulcers According to Evidence-Based Medicine

Chronic ulcers on the lower extremities are defined as trophic defects that show no signs of healing after 3 months of appropriate treatment or are not healed even after 12 months of treatment. Their incidence and prevalence are continuously increasing, and they currently represent not only a serious medical problem but also a socioeconomic issue. An overview article published by German physicians focuses on summarizing the therapy of leg ulcers according to the principles of evidence-based medicine.

Source: Wound Healing 15. 11. 2020

News Nutritional Therapy for Critically Ill Patients in the ICU –⁠ Current Recommendations

Critically ill patients hospitalized in the intensive care unit (ICU) require nutritional support to maintain adequate energy intake. Only by doing so can their clinical condition be prevented from worsening. Therefore, we summarize the current recommendations regarding nutritional therapy as part of care in the ICU in the following text.

Source: Parenteral Nutrition 4. 10. 2021

News Pregabalin can be chosen as the 1st line treatment for postherpetic neuralgia

The efficacy of pregabalin in patients with postherpetic neuralgia has been demonstrated in 4 multicenter randomized double-blind placebo-controlled studies.

Source: Neuropathic Pain 22. 6. 2020

News Pregabalin in the Treatment of Postherpetic Neuralgia Resistant to Gabapentin

Pregabalin appears to be an effective aid in patients with postherpetic neuralgia. This is evidenced by numerous clinical studies comparing the effects of pregabalin and gabapentin. It can be expected to alleviate painful symptoms and improve sleep quality, thereby significantly enhancing patients' quality of life.

Source: Neuropathic Pain 21. 5. 2021

News The Brain, Too, Has Its Midlife Crisis. How Do These Changes Relate to the Risk of Dementia in Old Age?

The human brain undergoes rapid changes during certain developmental periods. Childhood, adolescence, and advanced old age undoubtedly belong to these. For much of adulthood, it seems that nothing much actually happens. However, it turns out that the brain’s clock begins to accelerate around 40–50 years of age. What impact do these gradual changes have on our future health?

Source: 31. 10. 2024

News Why Do People Lose Weight Differently on GLP-1RA? The NBEA Gene Was Investigated

Glucagon-like peptide-1 receptor agonists (GLP-1RA) show promising anti-obesity effects, but their efficacy varies among individuals. A newly published study examined the role of the NBEA (neurobeachin) gene in weight loss while using these drugs, analyzing two large cohorts of real-world patients.

Source: 13. 8. 2025

News Pregabalin in Seniors Confirmed Its Safety and Effectiveness

A pooled analysis of 11 studies investigated the safety and effectiveness of pregabalin in seniors with neuropathic pain. Are the outcomes in these indicators different for older individuals than in the general population sample?

Source: Neuropathic Pain 25. 6. 2020

News Overview of Current Treatment Options for MRSA-Induced Pneumonia

Pneumonia caused by methicillin-resistant strains of Staphylococcus aureus (MRSA) remains a disease with high mortality requiring urgent treatment, whether it is a community-acquired or nosocomial infection. Italian authors published a review article at the beginning of 2022, describing the current available treatment modalities for this infection based on a literature survey.

Source: Anti-Infectives 8. 7. 2022